Defense – Page 43 – Communicable Diseases Research

A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa

녹농균에 대한 방어를 위해서는 보존된 미토콘드리아 감시 경로가 필요합니다

Research Article

Published on 2017-06-292022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A , -B and -C alleles

10,000개 이상의 HLA-A, -B 및 -C 대립유전자 서열의 무작위 변이로부터 기능적 다형성 구별

Research Article

Published on 2017-06-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] allele alleles amino-acid Analysis Antigen applicability binding site bone-marrow transplant bone-marrow transplants breadth common allele common alleles core alleles Defense determined by develop distinguishing domain Donor donors effort engage exponential growth Facilitating Families family family member Frequency functional Genetic variation glycoprotein growth HLA HLA class I HLA class I alleles HLA class I glycoproteins HLA complex HLA gene HLA genes HLA type HLA variation HLA-A HLA-B HLA-C HLA-C alleles homologous human gene human genes Human genome human population human populations immune functions immune reaction immune system genes incidence individuals Infection kill lymphocyte majority MOST Mutation mutation rate nucleotide nucleotides Older Patient peptide peptides Point mutation polymorphism populations Positive selection predict produced random receptors recombinant recombinants registries required selected sequence sequenced Sequencing Single nucleotide polymorphism single nucleotide polymorphisms Spread subject Substitution the patient variant variants Variation Viral viral infections
[DOI] 10.1371/journal.pgen.1006862 PMC 바로가기 [Article Type] Research Article

A highly specific phage defense system is a conserved feature of the Vibrio cholerae mobilome

매우 특이적인 파지 방어 시스템은 Vibrio cholerae mobilome의 보존된 특징입니다

Research Article

Published on 2017-06-082022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accelerate bacterial cell bacteriophage bacteriophages causative agent cell lysis cholerae chromosomal conserved contributed defend Defense diarrheal diarrheal disease disease cholera element Epidemic Evolution expansion favor feature FIVE Genetic genome replication genomic host cell host cells humans Infection investigated isolate killing Kinetics mechanism microbial community neighboring cell neighboring cells pathogen Patient phage phage genome phage-resistant phages predatory prevalent progeny Protective reduce respond selective spread to Stool strain unique Vibrio cholerae virulent widespread
[DOI] 10.1371/journal.pgen.1006838 PMC 바로가기 [Article Type] Research Article

Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses

Research Article

Published on 2017-06-022022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] 24 hours antiviral genes approach can be used caused Cell cellular response changes changes in coronavirus Defense dependent on disease Effect elicited epithelial cell expression Gene Expression Host host gene expression host response hours post-infection in vitro study in vivo Infection influenza A virus lung epithelial cell Lung epithelial cells mechanism mice microarray analysis Mild moderate mounted murine overlapping parameters Pathogenesis peaked respiratory tract respiratory viral infection respiratory viral infections respiratory virus response rhinovirus severity signature tissue remodeling transcription factor transcriptional Treatment type I interferon unique virus virus infection viruses
[DOI] 10.1371/journal.pone.0178408 PMC 바로가기 [Article Type] Research Article

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease

인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다

Research Article

Published on 2017-03-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall
[DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

Research Article

Published on 2016-10-262022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] Accessory accessory protein activate Activation acute respiratory syndrome antagonistic Antiviral antiviral host response antiviral host responses antiviral response antiviral signaling binding cause cellular conditions coronavirus coronavirus protein curtail Defense described disease dsRNA eIF2α evade expressing expression high mortality rate Host Human IFN-α/β increasingly independent Infection innate response interfere life-threatening Ligand mechanisms MERS-CoV Middle East mild respiratory molecular mechanism motif p4a pathway Pathways phosphorylate PKR platform Prevent Protein protein 4a receptor reported reservoirs respiratory respiratory syndrome coronavirus response SARS-CoV sequestering severe respiratory infection Spread Stress stress granule suppress suppressed therapeutic intervention translation type I interferon viral dsRNA Viral protein virus virus infection viruses
[DOI] 10.1371/journal.ppat.1005982 PMC 바로가기 [Article Type] Research Article

The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σ V Activation

항-시그마 인자 RsiV는 리소자임에 대한 박테리아 수용체입니다: 공결정 구조 결정 및 RsiV에 대한 라이소자임의 결합이 σ V 활성화에 필요하다는 입증

Research Article

Published on 2016-09-072022-09-17
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence acting activate activated Activation active site addition Bacteria Bacterial bind binding cascade Cell cell wall cleavage cleave complex crystal structure Defense demonstrated demonstration Determination enzymatic activity enzyme Evidence Factor function functions Gram-positive bacteria inhibit inhibitor initiated innate immune lysozyme many case mutant promoter protease Proteases Protein proteolytic receptor regulated required resistance mechanisms RIP RNA polymerase sensor signal Signal transduction specificity Structure suggested susceptible Target genes the cell These data thought Trigger triggering triggers X-ray
[DOI] 10.1371/journal.pgen.1006287 PMC 바로가기 [Article Type] Research Article

Human Management of a Wild Plant Modulates the Evolutionary Dynamics of a Gene Determining Recessive Resistance to Virus Infection

야생 식물의 인간 관리는 바이러스 감염에 대한 열성 내성을 결정하는 유전자의 진화 역학을 조절합니다

Research Article

Published on 2016-08-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] allele alleles analysed Analysis assays Capsicum coding sequence cultivation Defense Determining Diseases Diversity Dynamics Effect electrostatic Evidence evidence of Evolution full-length functional gene encode Genetic variation genetics host-pathogen interaction host-pathogen interactions Human impairing Infection infection assay infection assays initiation factor Interaction involved loci management mapping Mutation Neutral no evidence of pathogen phenotypic Phylogeny physical plant plant virus plants Population populations Positive selection Potyvirus Proteins R genes recessive recognize resistance resistance gene resistance mutations Result resulting severity supported susceptibility translation initiation triggering Variation variety Viral viruses
[DOI] 10.1371/journal.pgen.1006214 PMC 바로가기 [Article Type] Research Article

Floral Nectary Morphology and Proteomic Analysis of Nectar of Liriodendron tulipifera Linn.

Original Research

Published on 2016-06-142023-08-30
Journal: Frontiers in Plant Science [Category] E형 간염,

[키워드] Liriodendron tulipifera Defense morphology nectar protein proteomics
[DOI] 10.3389/fpls.2016.00826 PMC 바로가기 [Article Type] Original Research

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

초파리의 혈구에 의한 장 줄기 세포 활동의 원격 제어

Research Article

Published on 2016-05-272022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activate activated Activation activity Bacterial infection blood cell Blood cells canonical cell proliferation circulating contribute Control Coordinate Critical Defense Drosomycin Drosophila Express expression fat Gut haemocyte haemocytes Host receptors Immunity indicate induce Inflammation Injury Innate Interaction intestinal epithelium intestinal stem cell intestine involved JAK/STAT JAK/STAT pathway JNK pathway lipopolysaccharide liver mammals mode multiple tissues Mutation oral bacterial infection organ Organisms overcome pathway peptidoglycan Previous studies previous study proliferation promote recognize Regulation released remote required reveal secreted molecule secreted protein secreted proteins septic injury signaling pathway STAT STEM stem cell stimulate suggested survival systemic immune response tissue damage tissue repair turn Upd Upd1 Upd2 Upd3 Upds while wound
[DOI] 10.1371/journal.pgen.1006089 PMC 바로가기 [Article Type] Research Article