PEDV infection in neonatal piglets through the nasal cavity is mediated by subepithelial CD3 + T cellsResearch Article Published on 2021-02-172022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] Antiviral blood circulation catastrophic CD3 CD3+ T cells Contact DCs dendritic cell dissemination Effect epidemic diarrhea induce infect infected NEC Infection Infection of NEC Inflammatory cytokine intestinal intestinal mucosa intestine Invasion late stage nasal Nasal cavity nasal epithelial cell NECs Neonatal neonatal piglets PEDV replicate subepithelial T cell transfer virus [DOI] 10.1186/s13567-020-00883-w PMC 바로가기 [Article Type] Research Article
In vitro and In silico Models to Study SARS-CoV-2 Infection: Integrating Experimental and Computational Tools to Mimic “COVID-19 Cardiomyocyte”Physiology Published on 2021-02-172022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] “COVID-19 acute coronary syndromes addition adopted Affect animal model Arrhythmias cardiac adverse events cardiac disease cardiac function Cardiomyocytes caused Characteristics clinically Comorbidity contribute COVID-19 death disease dissemination drug drug treatments Effect effort electrolyte imbalance Gender Health hiPSC-CMs Immunological response in silico in vitro Infection mechanism MIMIC MINI Model modeling myocardial injury Numerous organ over pathophysiology Perspective pluripotent stem cells predict progression question reported respiratory review SARS-CoV-2 SARS-COV-2 infection the disease Thromboembolism treat Treatment virus [DOI] 10.3389/fphys.2021.624185 PMC 바로가기 [Article Type] Physiology
Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial란디올롤(베타 봉쇄)을 사용한 패혈성 쇼크의 역전에 대한 연구: 무작위 시험을 위한 STRESS-L 연구 프로토콜Intensive Care Published on 2021-02-162022-09-10 Journal: BMJ Open [Category] Fulltext, MERS, 임상, [키워드] 1:1 24 hours adjusted adult intensive & critical care Analysis approved assessment authorisation Beta Beta blocker Beta blockers bpm cardiac function Clinical practice clinical trial clinical trials collaboration competent Consensus defined detect dissemination drug East esmolol Ethics ethics committee failure Final group heart rate improvement include intensive care intensive care unit International International standards landiolol mechanism Medicine Medicines and Healthcare products Regulatory Agency Microbiology minute modulation Mortality Open-label Patient primary endpoint protocol randomisation randomised Randomised trial receive reduce Registered Registration reported required Research Ethics Result Safe Sepsis Septic shock Standard statistics & research methods steering committee submission survival Tachycardia the mean therapy Treatment Trial Trial Steering Committee usual care [DOI] 10.1136/bmjopen-2020-043194 PMC 바로가기 [Article Type] Intensive Care
Depressive and Anxiety Symptoms Among People Under Quarantine During the COVID-19 Epidemic in China: A Cross-Sectional StudyPsychiatry Published on 2021-02-152022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] adverse effects Anxiety anxiety symptom anxiety symptoms applied CDA China Chinese Combination Compliance conducted coronavirus disease correlated COVID-19 COVID-19 pandemic cross-sectional study Depression depressive dissemination effective GAD-7 Generalized identify individual knowledge less logistic regression model lower risk Measures moderate Multivariate analysis pandemic participant PHQ-9 Population prevalent Psychological public health measure quarantine Spread suffered symptoms of depression virus was performed [DOI] 10.3389/fpsyt.2021.566241 PMC 바로가기 [Article Type] Psychiatry
Infodemic and Fake News in Spain during the COVID-19 PandemicArticle Published on 2021-02-122022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] Affect changed coronavirus COVID-19 dissemination fake news Government health communication Health crisis identify Impact infodemic information Internet lack media New pandemic proliferation public opinion response social media Spain [DOI] 10.3390/ijerph18041781 PMC 바로가기 [Article Type] Article
A double blinded placebo controlled comparative clinical trial to evaluate the effectiveness of Siddha medicines, Kaba Sura Kudineer (KSK) & Nilavembu Kudineer (NVK) along with standard Allopathy treatment in the management of symptomatic COVID 19 patients – a structured summary of a study protocol for a randomized controlled trial증상이 있는 COVID 19 환자의 관리에서 표준 동종 요법 치료와 함께 Siddha 의약품, Kaba Sura Kudineer(KSK) 및 Nilavembu Kudineer(NVK)의 효과를 평가하기 위한 이중 맹검 위약 대조 비교 임상 시험 - 에 대한 연구 프로토콜의 구조화된 요약 무작위 대조 시험Letter Published on 2021-02-112022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] acute respiratory distress syndrome addition Adverse adverse events age age and sex appearance Arm Asymptomatic Bacterial biochemical markers blinded block calculated CAM change Chemical clinical clinical symptom Clinical symptoms clinical trial Complication complications Controlled count COVID COVID 19 COVID 19 patient CRP Ct value CTRI D-dimer Data analysis Date determine diagnose dimer dissemination drug Effect Effectiveness element eligibility eliminated enrolment evaluate exploratory ferritin food GMP group Herbal Hospital stay IL 6 IL6 incidence India Infection infiltration Inflammatory marker inflammatory markers Informed consent investigators involved Laboratory LDH literature management marker Medical Sciences Medicine Medicines Microsoft Excel moderate symptom moderate symptoms morning Night number objective outcome participant Patient patients PCR Placebo Pneumonia profile protocol randomised controlled trial randomization Randomized Randomized controlled trial Ratio recruited recruitment reduce reduction Registered Registration registry reported respiratory respiratory distress Respiratory distress syndrome risk Sample Sample size SARS-CoV-2 secondary Secondary objectives Secondary outcomes severe COVID-19 symptoms Siddha Siddha Medicine smoking SPIRIT guidelines statistician status Study protocol submission Sura symptomatic Taste tea the disease time Total Treatment Trial trial protocol Trial registration value Viral Viral load Viral pneumonia website were blinded [DOI] 10.1186/s13063-021-05041-x PMC 바로가기 [Article Type] Letter
Methodological quality of COVID-19 clinical researchCOVID-19 임상 연구의 방법론적 품질Article Published on 2021-02-112022-09-10 Journal: Nature Communications [Category] MERS, 비임상, 임상, [키워드] Abstract abstracts acceptance Analysis article articles breath Clinical findings Clinical studies clinical study cohort study Community comparable Comparative analysis Consequences controls COVID-19 COVID-19 pandemic disseminate dissemination early phase evaluate Evidence faster Final final analysis Health historical controls Infectious diseases information Methodological quality performed public health raised Research reveal SARS-CoV-2 scientific rigor screened systematic review while [DOI] 10.1038/s41467-021-21220-5 PMC 바로가기 [Article Type] Article
Impact of intravenous lidocaine on clinical outcomes of patients with ARDS during COVID-19 pandemia (LidoCovid): A structured summary of a study protocol for a randomised controlled trialCOVID-19 대유행 중 ARDS 환자의 임상 결과에 대한 정맥내 리도카인의 영향(LidoCovid): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-02-112022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 24 hour 24 hours acute renal failure acute respiratory distress acute respiratory distress syndrome Admission adverse event adverse events age albumin All participant All participants Anti-inflammatory effects approved aPTT ARDS Atrial fibrillation Bacterial Berlin Beta Bicarbonate biological sample biological samples blinded Blinding blockers blood count bolus bronchospasm cardiac rhythm Cardiogenic shock Care care providers Child bearing clinical Clinical data Clinical outcome clinical study collected Commission comparator complete blood count Complication computer-generated Concentration conducted Consumption control group cough COVID-19 COVID-19 pneumonia Covid-19 subgroup CRP D-dimers delirium diagnostic Disease progression disorders dissemination distribution Distribution ratio dosage Effect element ethics committee evaluate the effect evaluated Evolution experimental group extubation ferritin fibrinogen FiO2 followed by following form France French Gas exchange HCG Hospitalized hypnotics ICU IL-6 Ileus Impact incidence include inclusion criteria Inflammation Inflammatory marker inflammatory markers intensive care intensive care unit interval intervention group intravenous Intubated investigator LDH Length lidocaine Local local anaesthetics Local anesthetics Lymphocytes moderate moderate to severe Modification molecular mechanisms of pharmacological action Mortality NaCl number objective Older opioids outcome Pandemia PaO2 PaO2/FiO2 ratio parallel group participant Patient patients with ARDS PCT Phase 3 Placebo placebo-controlled Platelets Pneumonia pneumopathy Pneumothorax Prevent Primary outcome protection Protective protocol QTc random randomisation randomised randomised controlled trial randomize Randomized Randomly receive Recovery time recruitment Registered Renal Dialysis renal failure report respiratory distress RT-PCR Sample size SARS-CoV2 infection secondary endpoint Secondary endpoints sedated Severe acute respiratory syndrome severe ARDS Shock Social Security Social security system sore throat status Stratification stroke Study protocol supplementary material surgical syndrome tetraplegia thromboembolic Thromboembolic event timepoint Toxicity Treatment Trial Trial registration triglycerides troponin two group two groups university vasopressors Ventilation ventilator ventilator-free day Ventilator-free days website women written Informed Consent [DOI] 10.1186/s13063-021-05095-x PMC 바로가기 [Article Type] Letter
A quadruple blinded placebo controlled randomised trial to evaluate the effectiveness of an Iodine complex for patients with mild to moderate COVID-19 in Pakistan (I-COVID-PK): A structured summary of a study protocol for a randomised controlled trial파키스탄에서 경증에서 중등도의 COVID-19 환자에 대한 요오드 복합체의 효과를 평가하기 위한 4중 맹검 위약 대조 무작위 시험(I-COVID-PK): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-02-102022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 30-Day mortality Admission age alleviation alleviation of symptom approved Arm ARMS baseline blinded Blinding calculated Care care providers Chest chest scan Chronic illness clinic clinical Clinical improvement Clinical management co-morbidities co-morbidity comparator complex coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 adult patient COVID-19 adult patients Disinfection dissemination doctor Effectiveness Efficacy element enrolled evaluate excluded four group four groups Gender groups HRCT Infection information initial initial symptom initial symptoms Intention investigator investigators Iodine IRB lung involvement management guidelines Mild mild to moderate mild to moderate disease Moderate COVID-19 moderate disease morbidities National Health Service National Health Services non-pregnant females number objective outcome Pakistan participant Participants Patient patients PCR Placebo placebo-controlled Polymer positive Primary outcomes protocol radiological radiological improvement randomised randomised controlled trial Randomised trial randomization Randomized receiving recruited recruitment Registered remained reported resolved RT-PCR Sample size SARS-CoV-2 RT-PCR secondary outcome severity severity of symptom shown Standard standard care status Study protocol supplementary material Symptom symptomatic syrup the patient time Trial Version Viral viral clearance website [DOI] 10.1186/s13063-021-05081-3 PMC 바로가기 [Article Type] Letter
SARS-CoV-2 Infection and CMV Dissemination in Transplant Recipients as a Treatment for Chagas Cardiomyopathy: A Case ReportCase Report Published on 2021-02-102022-10-29 Journal: Tropical Medicine and Infectious Disease [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome adverse outcome ARDS caused Chagas disease CMV concomitant infection coronavirus Coronavirus disease 2019 COVID-19 death dissemination heart transplant higher risk Hospitalization ICU individual Infection intensive care Organ failure pandemic patients receiving recipient report SARS-CoV-2 SARS-COV-2 infection Septic shock severe pneumonia severity syndrome Transplant Trypanosoma cruzi [DOI] 10.3390/tropicalmed6010022 PMC 바로가기 [Article Type] Case Report