Establishment of Humanized Mice for the Study of HBVReview Published on 2021-02-192023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] chronic inflammation HBV HCC development human hepatocyte Human immune system human liver chimeras humanized mice Liver fibrosis [DOI] 10.3389/fimmu.2021.638447 PMC 바로가기 [Article Type] Review
Drug Discovery of Nucleos(t)ide Antiviral Agents: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th BirthdayReview Published on 2021-02-092024-09-02 Journal: Molecules [Category] 대상포진, [키워드] antiviral therapy HBV HCMV HCV HIV HSV nucleoside analogue nucleotide analogue VZV [DOI] 10.3390/molecules26040923 PMC 바로가기 [Article Type] Review
A Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: A structured summary of a study protocol for a randomised controlled trialCOVID19에 감염된 종양-혈액학적 환자에서 호흡 부전 진행을 예방하기 위한 바리시티닙의 효능을 평가하기 위한 I/II상 임상 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-02-052022-09-10 Journal: Trials [Category] MERS, 임상, 치료제, [키워드] 1:1 AAK1 absence activator Acute respiratory failure Administered administration Adverse adverse events affected alkaline phosphatase All participants allergy Alpha alpha error angina pectoris Antibiotics appearance ARDS Arm assigned AST/ALT Baricitinib baseline beta error Bilirubin Blinding Blood Breastfeeding can be used candidate Candidates capture Cardiac arrhythmia carried change clearance clinical clinical condition clinical suspicion clinical trials Coagulation Cohort Common Terminology Criteria Comorbidity Complete completion Compliance congestive heart failure control arm Controlled trial corticoid Corticosteroids COVID19 creatinine creatinine clearance CRP D-dimer Day Deep venous thrombosis description Deterioration Dexamethasone dimer discharge discretion disease dissemination diverticulitis dose dropout rate Duration of therapy ECMO Efficacy electronic case report form element eligibility criteria Enrollment evaluate exclusion criteria expected experimental arm extracorporeal membrane oxygenation febrile neutropenia ferritin followed by form fraction Gas exchange greater HBV HCV hemodynamic instability High-flow nasal cannula HIV HIV infection ICU immobilization immunological impossibility incidence include indication Infection infection with SARS-CoV-2 Inflammatory response interfere interferon Interim interim analysis interleukin interleukin 6 interstitial pneumonia Intervention intestinal perforation Invasive mechanical ventilation investigational agent investigator jak inhibitors Jak-STAT Laboratory laboratory parameter Laboratory parameters LDH less limit limits management mechanical ventilation medical history Medicine meet Methylprednisolone Mild ARDS Mortality multi organ failure nasal nasal cannula need for oxygen neutropenia neutrophil Neutrophils Non-invasive number objective on mechanical ventilation oncological patients onset of symptom open open label oral medication organ dysfunction Organ failure outcome oxygen oxygen support PaFi participant Participants Participation pathogen Pathogens pathway Patient patients performance status performed phase Phase 1 Phase 2 Phase I phosphatase platform Pneumonia poor prognosis positive Prednisone pregnancy test pregnant prejudice Prevent progression Prophylaxis Protein protein kinase protocol Psychiatric psychiatric illness Pulmonary embolism radiological randomisation randomised randomised controlled trial randomization Randomized Randomized controlled trial receive receptor recruitment REDCap REDcap platform reduce reduced Remdesivir removal report reported required respiratory Respiratory failure Respiratory function respiratory insufficiency respiratory tract Sample size SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection Secondary objectives Sepsis severe adverse event severe adverse events severe pneumonia severe respiratory failure Spain Spanish Standard of care STAT status study enrollment Study protocol supplemental oxygen requirement supplemental oxygen requirements supplementary material Support surgical surgical intervention Symptom symptomatic Tablet Therapies therapy thromboembolic disease thrombosis Tocilizumab total bilirubin Toxicity Transcription transducer Treatment treatment period Trial unstable angina use of corticosteroid Venous thrombosis Version viral endocytosis website Withdrawal worsening [DOI] 10.1186/s13063-021-05072-4 PMC 바로가기 [Article Type] Letter
The CCCTC-binding factor CTCF represses hepatitis B virus enhancer I and regulates viral transcriptionArticle Published on 2021-02-042023-06-03 Journal: Cellular microbiology [Category] B형 간염, [키워드] CTCF epigenetics HBV transcription insulation transcription regulation [DOI] 10.1111/cmi.13274 PMC 바로가기 [Article Type] Article
Combination of Entecavir or Tenofovir with Pegylated Interferon-α for Long-Term Reduction in Hepatitis B Surface Antigen Levels: Simultaneous, Sequential, or Add-on Combination TherapyReview Published on 2021-02-012023-06-03 Journal: International Journal of Molecular Sciences [Category] B형 간염, [키워드] Chronic Hepatitis B ETV HBsAg HBV peginterferon-α TDF [DOI] 10.3390/ijms22031456 PMC 바로가기 [Article Type] Review
Identification of the association between HBcAg-specific T cell and viral control in chronic HBV infection using a cultured ELISPOT assayArticle Published on 2021-02-012023-06-13 Journal: Journal of leukocyte biology [Category] B형 간염, [키워드] ELISPOT HBcAg HBV T cells [DOI] 10.1002/JLB.5MA0620-023RR
One-year Fibrosis-4 index helps identify minimal HCC risk in non-cirrhotic chronic hepatitis B patients with antiviral treatmentArticle Published on 2021-02-012023-06-13 Journal: Hepatology international [Category] B형 간염, Fulltext, [키워드] entecavir FIB-4 HBV Hepatocellular carcinoma PAGE-B tenofovir [DOI] 10.1007/s12072-020-10124-z PMC 바로가기
Partial abrogation of FXR-KNG1 signaling by carboxyl-terminal truncated HBx-C30 in hepatitis B virus-associated hepatocellular carcinomaArticle Published on 2021-02-012023-06-12 Journal: Virus research [Category] B형 간염, [키워드] C-terminal truncation FXR HBV HBx HCC. [DOI] 10.1016/j.virusres.2020.198264
The role of hepatitis B vaccine challenge dose in patients with underlying health conditionsArticle Published on 2021-02-012023-06-11 Journal: Human vaccines & immunotherapeutics [Category] B형 간염, [키워드] HBV health care workers Immunocompromised Italy vaccination [DOI] 10.1080/21645515.2020.1777058 PMC 바로가기
Epidemiological aspects and molecular characterization of the hepatitis B virus among blood donors in Lubumbashi, Democratic Republic of CongoArticle Published on 2021-02-012023-06-11 Journal: Transfusion clinique et biologique : journal de la [Category] B형 간염, [키워드] blood donor Donneur de sang genotypes HBV resistance Seroprevalence VHB. [DOI] 10.1016/j.tracli.2020.10.012