Current Therapeutics for COVID-19, What We Know about the Molecular Mechanism and Efficacy of Treatments for This Novel VirusCOVID-19에 대한 현재 치료제, 이 새로운 바이러스에 대한 분자 메커니즘 및 치료 효능에 대해 우리가 알고 있는 것Review Published on 2022-07-122022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] anti-viral agent anti-viral agents Antiviral approved caused clinical trial Combination coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 therapeutics current Defense early treatment effective therapy Efficacy Epidemics Evolution globe Hospitalization immunomodulatory individual molecular mechanism molecular mechanisms monoclonal antibodies monoclonal antibody morbidity and mortality Multiple multitude novel novel SARS-CoV-2 virus pandemic performed Prevent promise Randomized controlled trial remained SARS-CoV-2 SARS-CoV-2 virus searched Severe acute respiratory syndrome severe disease shown Spread the SARS-CoV-2 virus the United State Therapeutic approach therapeutic option Therapeutics Therapies therapy Treatment Trial United States Vaccine were used [DOI] 10.3390/ijms23147702 PMC 바로가기 [Article Type] Review
Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ωSARS-CoV-2에 대한 국소 인터페론 반응의 연령별 비교는 IFN-ε 및 -ω에 대한 역할을 제안합니다Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated Adults age anti-SARS-CoV-2 basal Basal transcription characterized children component components contribute develop diagnostic disease effective expression Genes highest Hospitalization IFN IFN response IFN-stimulated genes IFN-α IFN-ε IFN-λ1 IFN-ω IFNs individual infected individuals Infection Innate immunity interferon ISG ISG15 ISGs Mild Mild disease nasopharyngeal cell nasopharyngeal cells non-infected Occurrence Older overexpressed Protective quantified recent recognize relative expression response resulting risk role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individuals severe COVID-19 significantly higher starting swabs Symptom Transcription transcriptomic analysis type I type I and III IFNs type I interferon type III up-regulated [DOI] 10.3389/fimmu.2022.873232 PMC 바로가기 [Article Type] Article
The significance of advanced COVID-19 diagnostic testing in pandemic control measures전염병 통제 조치에서 고급 COVID-19 진단 테스트의 중요성Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advancement antibody Antigen causative agent caused combating Community condition conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak Defense diagnostic diagnostic test diagnostic testing diagnostic tests disease effort evade Evolution Hospitalization measure methodology mortality rates Mutation Novel coronavirus novel coronavirus disease nuclei pandemic Pandemic conditions reduced SARS-CoV-2 Scientific community Sensitivity and specificity severe acute respiratory syndrome Coronavirus shown Transmissibility Treatment strategies treatment strategy Vaccine Viral transmission Viral variants virus [DOI] 10.7150/ijbs.72837 PMC 바로가기 [Article Type] Review
Leveraging metabolic modeling to identify functional metabolic alterations associated with COVID-19 disease severity대사 모델링을 활용하여 COVID-19 질병 중증도와 관련된 기능적 대사 변경 식별Article Published on 2022-07-112022-09-11 Journal: Metabolomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute disease alteration approach claimed COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 pandemic COVID-19 sample COVID-19 samples disease Disease progression disease severity driver dysfunction functional Genome Genome-scale metabolic modeling healthcare highlight histidine hospital Hospitalization Host identify immunopathology Increased Infection Inflammation Inflammatory Inflammatory response innate immune response innate immune system Invasion investigated ketone lung damage machine machine learning marker mechanism metabolic pathway metabolism metabolite metabolomics muscular Musculoskeletal offer pathway Pathway enrichment analysis patients plasma metabolome positive Predictive Prevalence Prevent reduce SARS-CoV2 SARS-CoV2 infection severe COVID-19 Severe infection Tryptophan University of Virginia viral replication Virginia weakness with COVID-19 [DOI] 10.1007/s11306-022-01904-9 PMC 바로가기 [Article Type] Article
Clinical Outcomes of Sotrovimab Treatment in 10 High-Risk Patients with Mild COVID-19: A Case Series경증 코로나19 고위험 환자 10명을 대상으로 한 소트로비맙 치료의 임상 결과: 사례 시리즈Case Reports Published on 2022-07-082022-09-11 Journal: The American journal of case reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] administration Admission adverse event age AIDS Blood blood test cardiovascular disease Chronic kidney disease clinical Clinical practice Comorbidities Comorbidity COVID-19 COVID-19 in patient death effective Effectiveness Hemodialysis high risk Hospitalization information Kidney disease lung cancer Mild moderate moderate to severe Omicron variant on admission organ outcomes oxygen oxygen saturation Oxygen therapy Patient patients Pneumonia progression ranged recipients reduce Remdesivir risk risk factor Risk factors Safe Sery severe adverse event severe COVID-19 severe disease Sotrovimab SpO2 symptom onset the patient treated underlying disease underlying diseases variety virus [DOI] 10.12659/AJCR.936832 PMC 바로가기 [Article Type] Case Reports
The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infectionObservational Study Published on 2022-07-082022-10-04 Journal: Medicina clínica [Category] COVID19(2023년), SARS, 임상, [키워드] absence acute respiratory syndrome Admission association biochemical coronavirus Coronavirus disease 2019 COVID-19 death determine Diagnosis diagnosis of COVID-19 died discharge disease Enfermedad del coronavirus 2019 epidemiological Follow-up Hiponatremia y mortalidad Hospital admission Hospitalization hyponatremia Hyponatremia and mortality incidence increase in Infection material Mild moderate Mortality Patient patients with COVID-19 patients with SARS-CoV-2 persistence plasma Prognosis radiological ranged Ratio recorded retrospective cohort study SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severity Síndrome respiratorio agudo grave del coronavirus 2. variable worse prognosis [DOI] 10.1016/j.medcli.2021.07.006 PMC 바로가기 [Article Type] Observational Study
Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples타액 샘플에서 SARS-CoV-2 특이적 항체 검출Article Published on 2022-07-082022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] analyzed conversion rates coronavirus coronavirus disease COVID-19 detection diagnose diagnosed with COVID-19 Diagnosis diagnostic diagnostic test different time point different time points early diagnosis enrolled Evidence Hospitalization IgA IgG and IgM IgG level IgM Immunoglobulin immunoglobulins limit Molecular assay molecular assays nasopharyngeal nasopharyngeal sampling Nasopharyngeal swab nasopharyngeal swabs nucleic acid nucleic acids Patient positive rate positive rates recent Saliva saliva IgA. Sample SARS-CoV-2 serum serum samples Shenzhen Specific specimen Viral viral nucleic acid viral nucleic acid detection viral nucleic acids were measured [DOI] 10.3389/fimmu.2022.880154 PMC 바로가기 [Article Type] Article
A Highly Potent SARS-CoV-2 Blocking Lectin Protein렉틴 단백질을 차단하는 매우 강력한 SARS-CoV-2Article Published on 2022-07-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected blocking cell line coronavirus coronavirus disease Coronavirus disease-19 COVID-19 death Delta demonstrated drug effective entry of SARS-CoV-2 FIVE Frequency globe Hospitalization ICU admissions IFNAR Infection lectin mouse model Mutation New coronavirus omicron Omicron variants pandemic Please add keywords. potent preventing the transmission Prophylactic Protein SARS-CoV-2 secure severe acute respiratory syndrome Coronavirus social contact Spike protein spread of COVID-19 the spike protein variants Vero E6 Wuhan strain [DOI] 10.1021/acsinfecdis.2c00006 PMC 바로가기 [Article Type] Article
Assessment of hypokalemia and clinical prognosis in Patients with COVID-19 in Yangzhou, ChinaObservational Study Published on 2022-07-082022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] Admitted Patient Analysis assessment association branch China Chinese Clinical prognosis collected conducted correlated correlation COVID-19 criteria District electrolyte imbalance Hospital stay Hospitalization hypokalemia Jiangsu laboratory data Logistic regression analysis Moderate COVID-19 New non-ICU nucleic acid Patient patients with COVID-19 patients with moderate Potassium prevalent Prognosis ranged retrospective risk factor serum single-center was determined with COVID-19 [DOI] 10.1371/journal.pone.0271132 PMC 바로가기 [Article Type] Observational Study
Our experience with 80 cases of SARS-CoV-2-Clostridioides difficile co-infection: An observational studyObservational Study Published on 2022-07-082022-10-05 Journal: Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome analyzed Antibiotics changes in clinician Clostridioides difficile infection Co-infection consecutive patients coronavirus coronavirus disease COVID-19 Critical cured death rate Deceased digestive gut microbiota Hospital admission Hospital stay Hospitalization incidence Infection median median age Occurrence pandemic Patient patients raise recovered patient SARS-CoV-2 SARS-CoV-2 pneumonia severity significantly lower statistically significant Symptom the median the patient [DOI] 10.1097/MD.0000000000029823 PMC 바로가기 [Article Type] Observational Study