interferon – Page 43 – Communicable Diseases Research

Multicellular spatial model of RNA virus replication and interferon responses reveals factors controlling plaque growth dynamics

Research Article

Published on 2021-10-252022-10-28
Journal: PLoS Computational Biology [Category] COVID-19,

Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA

SARS-CoV-2 RNA에 대해 재검사를 받은 환자의 전사 특성 및 면역 기능 장애

Article

Published on 2021-10-232022-09-10
Journal: Journal of Molecular Cell Biology [Category] Coronavirus, SARS, 바이오마커, 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis caused CD4 CD8 CD8⁺ Characteristics contribute Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated differentiation discharge enrolled expression global public health Health crisis healthy control hospital ID1 IFITM10 Immune cell immune cells immune function immunological characteristics Infection inhibitor interferon low expression marker mechanism mononuclear cells natural killer cell Natural killer cells NK cells Occurrence Pathogenesis Patient patients Peripheral blood Peripheral blood mononuclear cells positive reduced respiratory RTP patients SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus significantly T cell T cells these cell These cells Transcriptome transcriptome sequencing transmembrane protein with COVID-19
[DOI] 10.1093/jmcb/mjab067 PMC 바로가기 [Article Type] Article

Immune Response in Severe and Non-Severe Coronavirus Disease 2019 (COVID-19) Infection: A Mechanistic Landscape

Immunology

Published on 2021-10-132022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] aggregation Analysis cDC2 Cell cell types cells cellular changes in contribute coronavirus disease COVID-19 cross talk disease healthy subjects heterogeneity highlight identify IFN-I immune immune cell type immune-remodeling innate immune response Interaction interferon landscape lineages low-density low-density neutrophils lymphoid MDSC mechanism megakaryocyte Monocytes multisystemic Natural killer cells neutrophil observé Patient patient cohort phenotype plasmablast plasmablasts reduction respond response responses robust scRNAseq severe COVID-19 patients severe disease severe infections severity Single-cell RNA sequencing subset type I while
[DOI] 10.3389/fimmu.2021.738073 PMC 바로가기 [Article Type] Immunology

The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation

Cellular Response to Infection

Published on 2021-10-132022-10-30
Journal: Journal of Virology [Category] Coronavirus, MERS,

[키워드] activate activated activating Activation acute respiratory syndrome addition antiviral drugs antiviral role Betacoronavirus cause caused Cell Characteristics coronavirus Coronavirus replication coronavirus-infected cell coronavirus-infected cells Coronaviruses decrease disease Diseases double-stranded eIF2α eIF2α Encephalomyelitis Endoplasmic reticulum endoplasmic reticulum stress ER stress facilitate Facilitating Formation Granule high mortality rate Host Human in vitro in vivo infected cells Infection inhibited innate response Interaction interferon invading pathogen mechanism MERS-CoV Middle East modulate nerve cell neurotropic new treatment strategy Occurrence outcome pathogenic pathway Phosphorylation PKR porcine hemagglutinating encephalomyelitis virus promoted Protein protein translation regulate regulated Replication repressed respiratory syndrome coronavirus reveal SARS-CoV SARS-CoV-2 signaling pathway specific treatment stress granule suppressed target translation attenuation triggered turn unfolded protein response UPR viral proliferation viral replication virus
[DOI] 10.1128/JVI.01695-21 PMC 바로가기 [Article Type] Cellular Response to Infection

Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells

인간 PSC 유래 심근세포 및 1차 내피 세포에서 항고혈압 약물 치료 및 SARS-CoV-2 감염에 대한 감수성

Article

Published on 2021-10-122022-09-11
Journal: Stem Cell Reports [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACEi acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter angiotensin angiotensin receptor blocker angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor Antihypertensive drug antihypertensive medication ARB Cell cell type Coronavirus-2 COVID-19 drug treatment endothelial Endothelial cell endothelial cells Enzyme inhibitor heart hPSC-derived cardiomyocytes Immunity interferon involved Lisinopril losartan MAPK medications membrane-bound mitogen mitogen-activated protein kinase modulate multicenter trials Necrosis NF-κB not affect nuclear pathogenicity Pathways Protein protein coding gene protein coding genes protein kinase receptor receptor blocker RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 signaling pathways significant difference significant differences stem cells susceptibility therapy TNF toxic effect toxic effects Transcriptome transcriptome change transcriptome changes Treatment Tumor tumor necrosis tumor necrosis factor
[DOI] 10.1016/j.stemcr.2021.08.018 PMC 바로가기 [Article Type] Article

Fulminant H1N1 and severe acute respiratory syndrome coronavirus-2 infections with a 4-year interval without an identifiable underlying cause: a case report

전격성 H1N1 및 중증급성호흡기증후군 코로나바이러스-2 감염, 4년 간격으로 뚜렷한 근본 원인 없이: 증례 보고

Case Reports

Published on 2021-10-082022-09-10
Journal: Journal of Medical Case Reports [Category] MERS, SARS, 변종, 신종인플루엔자,

[키워드] acute kidney acute respiratory syndrome Admission age Analysis Antiviral asymptomatic infection autoantibody Case report challenge clinical picture clinical recovery Comorbidity contributing to Coronavirus-2 Course COVID-19 demonstrated disease disease-causing enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Exome expression Factor fulminant genetic change Genetic changes genetic defect genetic defects Genetic variant genetic variants H1N1 H1N1 influenza healthy ICU immune immunological impairment indicate Infection infections Influenza intensive care intensive care unit admission interferon Interferon (INF) interferon pathway interferon response interferon-stimulated gene mechanical ventilation mononuclear cell mononuclear cells Pathways Patient Peripheral blood Perturbation reduced respiratory risk factor Risk factors SARS-CoV-2 Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity suffered susceptibility the interferon the patient triggered type I Variation Viral viral infection viral infections virus infection
[DOI] 10.1186/s13256-021-03113-9 PMC 바로가기 [Article Type] Case Reports

Similarities and Differences in the Acute-Phase Response to SARS-CoV-2 in Rhesus Macaques and African Green Monkeys

Immunology

Published on 2021-10-062022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] absolute monocyte count acute response African African green monkey AGM AGMs alteration Analysis Blood breadth Cohort Correlation analysis COVID-19 COVID-19 disease Critical defined difference effective vaccine Evidence exhibiting gene network greater green hallmark help immune Infection interferon ISG ISGs macaque Monkey nasopharyngeal neutrophil (PMN) neutrophil degranulation NHP normalized occurred outcome pathology pathway Post-infection presenting Pulmonary pathology Regulation response rhesus macaque SARS-CoV-2 SARS-COV-2 infection similarity stimulated Systems biology timepoint transcriptional transcriptional change Transcriptome type I understanding upregulation WGCNA
[DOI] 10.3389/fimmu.2021.754642 PMC 바로가기 [Article Type] Immunology

Antiviral Effect of Hyunggaeyungyo-Tang on A549 Cells Infected with Human Coronavirus

Research Article

Published on 2021-10-062022-10-31
Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19,

[키워드] A549 A549 cell acting addition Administered antiviral effects Betacoronavirus Cell conducted control group coronavirus Coronavirus infection Coronavirus infections coronavirus RNA decrease Effect Effectiveness expression expression level herbal medicine human coronavirus IFI27 Ifi44 IFI44L IFI6 IKK IL-1 indicate individual inhibit Injury interferon IRF7 ISG15 ISGs mRNA mRNA expression mRNA level OASL OC43 over oxidative pathway Proinflammatory cytokine PROTECT reduce reduction Replication Research Result significantly stimulated Symptom TNF- α treat treated Treatment viral infectious diseases worldwide pandemic
[DOI] 10.1155/2021/4494389 PMC 바로가기 [Article Type] Research Article

Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity

어린이의 SARS-CoV-2에 대한 강력한 타고난 반응은 적응 면역을 손상시키지 않으면서 성인보다 빠르게 해결됩니다.

Article

Published on 2021-10-052022-09-11
Journal: Cell Reports [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] activated Activation adaptive Adults Anti-viral antibodies antibody antiviral response B cell B cells Blood blood cell Cell changes in characterized children Clusters Course COVID-19 CXCL10 Cytokines dendritic cell dendritic cells disease course Effect faster gene profile GM-CSF immune signature Immunity Increases increases in Infection Inflammation initial viral load innate response innate responses interferon less longitudinal analysis mild infection monocyte Monocytes resolution. responses robust SARS-CoV-2 SARS-COV-2 infection Symptom Symptoms the disease the SARS-CoV-2 Viral
[DOI] 10.1016/j.celrep.2021.109773 PMC 바로가기 [Article Type] Article

A Bioinformatics Approach for the Prediction of Immunogenic Properties and Structure of the SARS-COV-2 B.1.617.1 Variant Spike Protein

면역 원성 특성의 예측 및 SARS-COV-2의 구조 B.1.617.1 변이 스파이크 단백질의 생물 정보학 접근법

Research Article

Published on 2021-10-052022-09-10
Journal: BioMed Research International [Category] 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Amino acid amino acid sequence Analysis analyzed Antigen antigenic B cell B cell epitopes B- and T-cell epitopes B.1.617.1 bioinformatics chemokine Coronavirus-2 COVID-19 drug Epitopes IFN immune function immunogenic Immunological response immunological responses in silico analysis in silico Approach incidence interferon Interferon-gamma mitigate Mortality objective predicted prediction property Protective Protein protein structure provide Region respiratory Respiratory illness responsible Result S protein S protein of SARS-CoV-2 SARS-CoV 2 SARS-CoV-2 second wave sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 spike Structure subunit T cell T cell epitope T cell epitopes T-cell epitopes tertiary structure Vaccine variant variant of SARS-CoV-2 variant S protein was used
[DOI] 10.1155/2021/7251119 PMC 바로가기 [Article Type] Research Article