The role of interleukin‐6 in monitoring severe case of coronavirus disease 2019코로나 바이러스 질병 2019의 중증 사례 모니터링에서 인터루킨-6의 역할Article Published on 2020-06-052022-09-25 Journal: EMBO Molecular Medicine [Category] SARS, 바이오마커, 진단, [키워드] analyzed baseline Biomarker body temperature C‐reactive protein can be used changes in Chest computed tomography coronavirus disease Coronavirus disease 2019 COVID CRP Cytokine storm D‐dimer decrease disease disease monitoring Disease progression exacerbated ferritin Hospitalization immunology interleukin‐6 lactate dehydrogenase LDH lymphocytopenia marker Microbiology, Virology & Host Pathogen Interaction Patient patients positively correlated progressed Severe case severe cases severe disease severity Significant significant increase [DOI] 10.15252/emmm.202012421 PMC 바로가기 [Article Type] Article
Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-032022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 24 hour acute respiratory distress syndrome addition Administered Anakinra anti-IL-1 anti-IL-6 anti-IL-6 receptor antibody Bacterial Belgium binding blinded blockade Blood characterized chest X-ray chimeric clinical Clinical improvement Combination composed Coronavirus infection COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient CT scan death defined discharge dissemination dose drug Effectiveness element EudraCT excluded experimental arm factorial design Fungal infection hospital hospital discharge Hospitalized hospitals hypoxia hypoxic respiratory failure ICU IL-1 IL-6 IL-6 blockade IL-6 receptor interleukin 1 blockade interleukin 6 blockade Intravenous injection Invasive mechanical ventilation LDH lymphopenia mechanical ventilation non-invasive ventilation number objective on mechanical ventilation open label Open-label outcome oxygen Oxygenation paO2/fiO2 participant Participants Patient patients with COVID-19 Phase 3 primary end point protocol randomisation randomised randomised controlled trial randomization Randomized receive receptor recruited recruitment Registered response Sample size Serum ferritin siltuximab standard care Standard of care status Study protocol subcutaneous injection supplemental oxygen syndrome System systemic cytokine systemic cytokine release syndrome Tocilizumab treated Trial usual care was selected Web website [DOI] 10.1186/s13063-020-04453-5 PMC 바로가기 [Article Type] Letter
Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control studyResearch Article Published on 2020-06-032022-10-28 Journal: BMC Medicine [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval Admission advanced age age Analysis case-control study China Clinical characteristics clinician conducted Coronavirus disease 2019 COVID-19 COVID-19 patient deteriorate Deterioration disease Dyspnea Elderly patient enrolled hospital hypertension identify independent risk factor lactate dehydrogenase LDH male Mild mild COVID-19 patients mild illness mild patients multicenter multivariate logistic regression Odds ratio Older Patient progression Protein Result SARS-CoV-2 severe pneumonia susceptibility [DOI] 10.1186/s12916-020-01633-7 PMC 바로가기 [Article Type] Research Article
Clinical and Immune Features of Hospitalized Pediatric Patients With Coronavirus Disease 2019 (COVID-19) in Wuhan, ChinaResearch Published on 2020-06-032022-10-29 Journal: JAMA Network Open [Category] COVID-19, [키워드] acute respiratory syndrome age alanine aminotransferase ALT analyzed Aspartate aminotransferase association AST B cell B cells biochemical Case series case sery caused CD4 Characteristics children CK-MB clinical Clinical characteristics Clinical management collected coronavirus coronavirus disease COVID-19 Critically ill decrease disease severity dysregulation exposure feature finding immune immune response Immunoglobulin Importance Infection Inflammatory cytokine Inflammatory response information interferon γ interquartile range involved laboratory abnormality laboratory-confirmed lactate dehydrogenase LDH liver lymphocyte Lymphocytes lymphopenia measure median Mild mild case mild cases moderate Moderate COVID-19 moderate disease myocardial injury Necrosis neutrophil Neutrophils objective occurred participant Pathogenesis pathogenesis of SARS-CoV-2 pathologic process Patient Pediatric patient Pediatric patients Pneumonia Point positive Relevance reported Result SARS-CoV-2 SARS-COV-2 infection setting severe cases single-center statistically significant difference systemic inflammation T cell T cells with COVID-19 with mild disease Wuhan Wuhan, China [DOI] 10.1001/jamanetworkopen.2020.10895 PMC 바로가기 [Article Type] Research
Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control studyResearch Paper Published on 2020-05-182022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Admission analyzed BNP Brain breath C-index C-reactive protein cardiac troponin case-control study change Characteristics clinical Clinical data clinical feature Clinical practice Coronavirus disease-19 correlated Course COVID-19 Critical care CRP D-dimer death demonstrated diastolic pressure discharge dynamic dysfunction event Factor feasible hospitalized patient IL-6 independent risk factor Inflammation information Isolation laboratory parameter lactate dehydrogenase LDH Logistic Logistic regression lymphocyte multivariate logistic regression neutrophil outcome parameter Patient PCT peptide predict procalcitonin Prognosis Radiographic Radiography rationale Result Risk factors severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly SpO2 syndrome two group was collected Wuhan, China [DOI] 10.7150/ijms.46614 PMC 바로가기 [Article Type] Research Paper
The implications of preliminary screening and diagnosis: Clinical characteristics of 33 mild patients with SARS-CoV-2 infection in Hunan, ChinaArticle Published on 2020-04-302022-11-01 Journal: Journal of Clinical Virology [Category] COVID-19, SARS, [키워드] accompanied age analyzed Asymptomatic carriers asymptomatic patient Attention can be used Characteristics characteristics of patient China clinical Clinical features clinical manifestation clinical symptom Clinical symptoms Cluster collected coronavirus coronavirus 2 cough COVID-19 COVID-19 patient COVID-19 patients D-dimer described diagnose Diagnosis diarrhea disease eight elevated Epidemic epidemiological erythrocyte sedimentation rate female Fever ground-glass opacity Hunan implication Infection laboratory result Laboratory results LDH lymphocyte male mild cases mild patient Most patient nucleic acid nucleic acid test objective occurred outbreak Patient patients patients with COVID-19 Pharyngeal swab plaque positive Protein reduction in regions respiratory Result SARS-CoV-2 SARS-COV-2 infection significantly Spread stools Symptom Tear the median throat swab viral infection were infected White blood cell Whole blood Wuhan [DOI] 10.1016/j.jcv.2020.104397 PMC 바로가기 [Article Type] Article
Clinical characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia, North Italy, 21 to 28 February 2020Rapid Communication Published on 2020-04-232022-10-31 Journal: Eurosurveillance [Category] COVID-19, SARS, [키워드] Antiviral treatment Caucasian patient Characteristics clinical Clinical characteristics coronavirus disease COVID-19 died discharge discharged Europe hospital Italy lactate dehydrogenase LDH median North outbreak outcome Patient Pavia Retrospective study SARS-CoV-2 severe disease single hospital Treatment [DOI] 10.2807/1560-7917.ES.2020.25.16.2000460 PMC 바로가기 [Article Type] Rapid Communication
Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy StudyOriginal Research Article Published on 2020-04-042022-10-27 Journal: Archives of Academic Emergency Medicine [Category] COVID-19, [키워드] Accuracy addition age alanine aminotransferase ALT Aspartate aminotransferase AST AUC Biochemistry; blood cell count Biomarkers C-reactive protein (CRP can be used clinic conducted COVID-19 COVID-19 case COVID-19 patients COVID-19 test CRP detection diagnostic evaluate evaluated help Iran laboratory parameter lactate dehydrogenase LDH male neutrophil Patient positive positive RT-PCR predict real time Reverse transcriptase polymerase chain reaction ROC Curve RT-PCR SARS-CoV-2 serum serum albumin significantly higher Tehran the mean two group WBC White blood cell PMC 바로가기 [Article Type] Original Research Article
Positive association between severity of COVID-19 infection and liver damage: a systematic review and meta-analysisMeta-Analysis Published on 2020-01-012022-10-31 Journal: Gastroenterology and Hepatology From Bed to Bench [Category] COVID-19, [키워드] 1.26 95% CI ALP ALT alteration Analysis analyzed association AST Biomarker caused circulating Cochrane Library coronavirus COVID-19 COVID-19 patients COVID-19 severity database early stage elevated evaluated females greater Health Infection ISI LDH liver Liver damage liver enzyme liver enzymes Liver function male Meta-analysis not significant outbreak Patient patients Prognosis random-effects model representing respiratory risk SARS-CoV-2 SARS-COV-2 infection searched Severe COVID-19 Infection Severe patient severity of COVID-19 suggested systematic review the disease total bilirubin Web of Science PMC 바로가기 [Article Type] Meta-Analysis
Lactate dehydrogenase is a prognostic indicator in patients with hepatocellular carcinoma treated by sorafenib: results from the real life practice in HBV endemic areaResearch Paper Published on 2016-12-272023-06-02 Journal: Oncotarget [Category] B형 간염, [키워드] HBV endemic area Hepatocellular carcinoma LDH Prognosis sorafenib [DOI] 10.18632/oncotarget.13428 PMC 바로가기 [Article Type] Research Paper