Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-β in Triggering Inflammatory Signals in Cells of Distant OrganArticle Published on 2021-03-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Analysis approach carried CCL5 Cell chemokine controls COVID-19 COVID-19 patient COVID-19 patients Cytokine storm Cytokines Distant examined Exosome Exosomes expression FGB fibrinogen-β healthy healthy subjects healthy volunteer hepatocyte IL-6 Immunity infected cell interleukin-6 Ligand mass spectrometry motif NF-κB organ overshoot Pathogenesis pathway plasma pro-inflammatory cytokine proteomic SARS-COV-2 infection signal Signaling significant increase stimulate tenascin-C tissue damage TNC TNF-α transported tumor necrosis factor-α [DOI] 10.3390/ijms22063184 PMC 바로가기 [Article Type] Article
Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational studyObservational Study Published on 2021-03-192022-10-04 Journal: Critical Care [Category] 임상, [키워드] acute respiratory distress adopted adult COVID-19 patient age analyzed approved ARDS Arterial blood ga Brain Carbon dioxide removal cerebral Cerebral oxygenation change conducted coronavirus correlated correlation COVID-19 patient COVID-19 patients Critically ill Effect Effectiveness Efficacy evaluate Inhaled Italy Liguria lung male mechanically ventilated median nitric oxide oxygen oxygen saturation Oxygenation PaO pathophysiological mechanisms patients performed Prone position prone positioning prospective observational study protocol recruitment Recruitment maneuvers reduction Registration remains uncertain rescue Rescue therapies Result resulting significant increase significantly Study protocol supplementary material syndrome Therapies therapy ventilatory [DOI] 10.1186/s13054-021-03537-1 PMC 바로가기 [Article Type] Observational Study
The Influence of Social Distancing on COVID-19 Mortality in US Counties: Cross-sectional StudyOriginal Paper Published on 2021-03-182022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, [키워드] addition approach average country covariate COVID-19 COVID-19 mortality death deaths decrease determine Effect Effectiveness examined Factor generate hospital implementation increase in influence lifted marginal effects Mortality National negative binomial model objective physical distance previous study proportion reported resource Result separated significant increase significantly social distancing social distancing measures the mean the United State [DOI] 10.2196/21606 PMC 바로가기 [Article Type] Original Paper
Deep Learning in the Detection and Diagnosis of COVID-19 Using Radiology Modalities: A Systematic Review방사선학 양식을 사용한 COVID-19 감지 및 진단의 딥 러닝: 체계적인 검토Review Article Published on 2021-03-152022-09-12 Journal: Journal of Healthcare Engineering [Category] 진단, [키워드] article conducted COVID-19 COVID-19 pandemic database deep deep learning detection Diagnosis diagnosis of COVID-19 diagnostic Diagnostic method disease early stage exclusion criteria False-positive Inclusion learning lowest machine-learning Material and Method non-COVID-19 case offer patients provide radiologic radiological radiology reduce Research researcher Result review Safe selected Sensitivity and specificity significant increase systematic review the disease unique Web of Science [DOI] 10.1155/2021/6677314 PMC 바로가기 [Article Type] Review Article
Effects of home quarantine during COVID-19 lockdown on physical activity and dietary habits of adults in Saudi ArabiaArticle Published on 2021-03-152022-10-04 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] 95% confidence interval affected alleviate Analysis Arabic between meal country COVID-19 COVID-19 pandemic dietary habit Effect English Epidemiology Google Government Health Health care home quarantine impacted lockdown male pandemic participant participated physical activity platform Prevalence Public public health quarantine response restrict Saudi Arabia significant increase significantly significantly increased Spread [DOI] 10.1038/s41598-021-85330-2 PMC 바로가기 [Article Type] Article
Blood Interferon-α Levels and Severity, Outcomes, and Inflammatory Profiles in Hospitalized COVID-19 Patients입원한 COVID-19 환자의 혈액 인터페론-α 수준 및 중증도, 결과 및 염증 프로필Immunology Published on 2021-03-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 치료기술, 치료제, [키워드] association Blood blood lymphocyte blood sample Blood samples clinical clinical condition clinical manifestation clinical manifestations clinically Cohort conditions Control control patient controls COVD-19 COVID-19 COVID-19 patient COVID-19 severity COVID−19 Deficient defined detectability died each time-point enrolled Enrollment evaluate Evolution expression hospitalized patient identify IFN-α IFN-β IL-10 Immune cell immune cells Immune profile immunoassay immunological pathway immunological pathways improvement Infection interferon interferon response Intervention Level Lymphocytes manifestation matched controls mechanism mediators Mortality multiplex Patient patients who survived pharmacological profile proportion Prospective Study recruitment required respiratory Respiratory failure Respiratory Support SARS-COV-2 infection SARS–CoV−2 severe manifestations of COVID-19 severity significant increase study period study population subjects survived survivor target the interferon threshold were assessed [DOI] 10.3389/fimmu.2021.648004 PMC 바로가기 [Article Type] Immunology
Acute cardiovascular hospitalizations and illness severity before and during the COVID ‐19 pandemicClinical Investigations Published on 2021-03-072022-10-31 Journal: Clinical Cardiology [Category] COVID-19, [키워드] Admission affected cardiovascular cardiovascular disease Cohort coronary syndrome COVID COVID‐19 COVID‐19 CVD declined disease Duke Evaluating groups heart failure Hospitalization hospitalizations Illness severity LVEF measure Mortality mortality risk North outcomes pandemic parameters Patient per day reduced reductions in Result risk Risk scores significant increase stroke System university [DOI] 10.1002/clc.23590 PMC 바로가기 [Article Type] Clinical Investigations
Typical symptoms of common otorhinolaryngological diseases may mask a SARS-CoV-2 infectionMiscellaneous Published on 2021-03-072022-10-31 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID-19, SARS, [키워드] acute respiratory syndrome addition Aerosols Asymptomatic Clinical practice clinical symptom Contact coronavirus COVID-19 COVID-19 symptom demographic data determine diagnose diagnosis of COVID-19 disease Diseases droplet HCW Health care worker health care workers medical history molecular observation period Otorhinolaryngological pandemic Patient PCR test PCR testing performed Personal protective equipment positive positive patient positive rate Probability replicate Result Retrospective study risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR test SARS-CoV-2 RNA SARS-CoV-2 testing SARS-CoV-2-positive patient significant increase Symptom Taking the patient the SARS-CoV-2 transmitted Treatment Typical upper respiratory tract were assessed [DOI] 10.1007/s00405-021-06726-4 PMC 바로가기 [Article Type] Miscellaneous
“Impact of COVID-19 pandemic lockdown on early onset of puberty: experience of an Italian tertiary center”Letter to the Editor Published on 2021-03-052022-10-29 Journal: Italian Journal of Pediatrics [Category] COVID-19, [키워드] analyzed Atypical caused children China Cohort coronavirus 2 coronavirus disease country COVID-19 COVID-19 lockdown COVID-19 pandemic database defined endocrinology Epidemic Factors global pandemic Government health emergency Italian Italy lockdown Measures Novel coronavirus outpatient clinic outpatient consultation pathogenic Pneumonia Precocious Puberty Preliminary data rapid increase recorded reported respiratory SARS-CoV-2 SARS-CoV2 pandemic significant increase unit [DOI] 10.1186/s13052-021-01015-6 PMC 바로가기 [Article Type] Letter to the Editor
The direct and indirect effects of COVID‐19 pandemic in a real‐life hematological setting실제 혈액학 환경에서 COVID-19 대유행의 직간접적 영향Original Article Published on 2021-03-032022-09-11 Journal: Cancer Reports [Category] MERS, SARS, 치료제, [키워드] advanced respiratory support aims average average values baseline characteristics Characteristics Chemotherapy chemotherapy sessions clinical Cohort collected coronavirus 2019 disease COVID‐19 COVID‐19 D‐dimer death disease elevated Factor healthcare hematological hematology indirect effect indirect effects initial leukemia Logistic lymphoid lymphoma male Male sex median median age moderate moderate to severe Mortality mortality rate mortality rates negative Novel coronavirus outcome pandemic Patient patients reduction in reported resource respiratory respiratory insufficiency Result SARS‐CoV‐2 significant increase survivor Telemedicine Univariate analysis Variation variations vasoactive drug vasoactive drugs [DOI] 10.1002/cnr2.1358 PMC 바로가기 [Article Type] Original Article