single-center – Page 43 – Communicable Diseases Research

Clinical characteristics and outcome of hospitalized COVID-19 patients with diabetes: A single-center, retrospective study in Iran

Clinical Trial

Published on 2020-11-012022-10-05
Journal: Diabetes research and clinical practice [Category] SARS, 임상,

Effect of Combination Therapy of Hydroxychloroquine and Azithromycin on Mortality in Patients With COVID-19

Observational Study

Published on 2020-11-012022-10-05
Journal: Clinical and translational science [Category] SARS, 임상,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome age Azithromycin azithromycin treatment C reactive protein cohort study Combination combination treatment Comorbidities consecutive patient contraindications coronavirus coronavirus disease COVID-19 death drug Effect Evidence hazard ratio HCQ In-hospital death in-hospital mortality Infection Kaplan-Meier curve log rank test multivariable patients treated performed Pneumonia positive airway pressure primary end point randomized trial receive recorded reduced regression analysis retrospective SARS-CoV-2 single-center the median Treatment treatment group use of hydroxychloroquine women
[DOI] 10.1111/cts.12860 PMC 바로가기 [Article Type] Observational Study

Association of Troponin Levels With Mortality in Italian Patients Hospitalized With Coronavirus Disease 2019: Results of a Multicenter Study

2019년 코로나바이러스 질병으로 입원한 이탈리아 환자의 사망률과 트로포닌 수치의 연관성: 다기관 연구 결과

Multicenter Study

Published on 2020-11-012022-09-11
Journal: JAMA Cardiology [Category] Fulltext, SARS, 치료기술,

[키워드] Acute coronary syndrome acute kidney failure Admission age Analysis Atrial fibrillation bleeding cardiac disease cardiac troponin Characteristics Chinese clinical Clinical characteristics Comorbidity Complication consecutive patient consecutive patients Coronary artery Coronary artery disease coronary syndrome coronavirus disease Coronavirus disease 2019 COVID-19 cross-sectional cross-sectional study defined delirium died elevated European evaluate greater heart failure higher risk Hospitalization Hospitalized hypertension In-hospital in-hospital complications in-hospital mortality independent independent variable initial Injury Italian Italian patient Italian patients Kidney failure laboratory-confirmed Laboratory-confirmed COVID-19 Level major bleeding male Mortality mortality rates multicenter multicenter study multiorgan failure multivariable Cox regression myocardial injury normal values Older outcome Patient patients patients hospitalized patients with COVID-19 plasma populations Prevalence Prognostic value Pulmonary embolism reported Result risk Sepsis single-center stratified troponin troponin I troponin level troponin levels troponin T were excluded white with COVID-19
[DOI] 10.1001/jamacardio.2020.3538 PMC 바로가기 [Article Type] Multicenter Study

Tocilizumab in patients with severe COVID-19: A single-center observational analysis

중증 코로나19 환자의 토실리주맙: 단일 센터 관찰 분석

Observational Study

Published on 2020-11-012022-09-12
Journal: Journal of medical virology [Category] 임상, 진단,

[키워드] Admission Analysis baseline benefit changes in clinical Clinical improvement common Comorbidity coronavirus disease COVID-19 CRP cytokine cytokine release Cytokine release syndrome Cytokine storm decrease develop Diabetes Mellitus diagnosed with COVID-19 died discharged disease severity dose elevated evaluate evaluated expired glucocorticoid hospital Hydroxychloroquine hypertension IL-6 IL-6 antagonist interleukin-6 receptor marker Mortality Most patient oxygen-support oxygenation status Patient patient population proinflammatory Protein reported retrospective severe COVID-19 Severe respiratory distress single-center Support thought Tocilizumab transferred Treatment Trial Ventilation worsened
[DOI] 10.1002/jmv.26191 PMC 바로가기 [Article Type] Observational Study

The effect of favipiravir on QTc interval in patients hospitalized with coronavirus disease 2019

코로나바이러스 질환으로 입원한 환자의 QTc 간격에 대한 favipiravir의 효과 2019

Article

Published on 2020-11-012022-09-11
Journal: Journal of electrocardiology [Category] SARS, 치료제,

Assessment of boron-containing compounds and oleoylethanolamide supplementation on the recovery trend in patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-10-272022-10-29
Journal: Trials [Category] Coronavirus, MERS, SARS,

[키워드] 1:1 accompany age Antibody test anticipated assessment assigned blinded block Boron-containing compounds Breastfeeding C-reactive protein C-reactive protein (CRP calculated CBC center clinical Clinical symptoms clinical trial complete blood count Compound computer-generated conducted COVID-19 Critical Data analysis diagnosis of SARS-CoV-2 dissemination double-blind dry cough element erythrocyte sedimentation rate ESR exclusion criteria fatigue Features female Fever four groups group groups Imam include inclusion criteria Infection information Intervention investigator Iran male Medical Sciences number nutrition objective Oleoylethanolamide outcome participant Patient patients patients with COVID-19 PCR placebo-controlled clinical trial Pneumonia polymerase chain Pregnancy primary end point profile protocol randomised randomised controlled trial randomization Randomized Randomized controlled trial Randomly receive Registered registry Reza Sample size single-center status Study protocol subject Tabriz total sample size Treatment Trial university Version website
[DOI] 10.1186/s13063-020-04820-2 PMC 바로가기 [Article Type] Letter

Evaluation of the efficacy and safety of favipiravir and interferon compared to lopinavir/ritonavir and interferon in moderately ill patients with COVID-19: a structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-10-272022-10-29
Journal: Trials [Category] COVID-19, MERS, SARS,

[키워드] 1:1 Adverse drug reaction allergy allocation sequence antibody tests anticipated Arm ARMS assigned Bandar Abbas Blinding block randomization Breastfeeding carried China cirrhosis clinical Clinical improvement company Computed tomography conditions Confirmed Control control group Controlled trial COVID-19 criteria Critical Department Diagnosis dissemination dose Efficacy and safety element evaluate Favipiravir Fever FIVE generate Hepatitis history Hospital stay Hospitalization ill patient in both groups incidence India infection with SARS-CoV-2 interferon intervention group Iran liver diseases Lopinavir/ritonavir nasopharyngeal sample number objective Open-label Other outcome parallel-group participant Patient patients Phase 3 Placebo Pneumonia polymerase chain Primary outcome protocol random randomization Randomized Randomized controlled trial receive registry renal respiratory routine care RT-PCR Sample size SARS-CoV-2 screened secondary outcome single-center Study protocol treatment arm Trial trial protocol two group Viral load web-based system website X-ray Zhejiang
[DOI] 10.1186/s13063-020-04747-8 PMC 바로가기 [Article Type] Letter

Evaluation of the efficacy and safety of Melatonin in moderately ill patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial

중등도의 COVID-19 환자에서 멜라토닌의 효능 및 안전성 평가: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2020-10-262022-08-13
Journal: Trials [Category] MERS, SARS, 임상,

[키워드] 1:1 acute respiratory syndrome Adverse drug reaction Adverse drug reactions alcohol All study participants allergy allocation sequence Alpha anticipated Antiviral Arm ARMS assigned Bandar Abbas blinded Blinding block randomization Breastfeeding C-reactive protein Chain Reaction chronic hepatitis cirrhosis clinical clinical symptom Clinical symptoms clinical trials Clinicians Computed tomography conducted Confirmed Control control group Corticosteroids COVID-19 COVID-19 pneumonia criteria Critical Department Depression diabetes Diabetes Mellitus Diagnosis Diseases dissemination dose double-blind drug drugs education Efficacy and safety element evaluate exclusion criteria faculty feature generate Hepatitis history Hospitalization Hospitalized hypertension IL-1β IL-6 ill patient IMPROVE incidence inclusion criteria inflammatory parameter inflammatory parameters Inflammatory responses Informed consent interleukin interleukin-1β Iran liver diseases Medical Sciences Medicines melatonin Ministry of Health number Nurses objective outcome oxygen oxygen saturation parallel-group participant Participants Patient patients patients randomized pharmaceutical Pharmacy Placebo placebo-controlled clinical trial Pneumonia polymerase chain polymerase chain reaction polymerase chain reaction) positive Pregnancy Primary outcome Primary outcomes protocol random randomization Randomized Randomized controlled trial regimen Registered registration date registration number registry Research respiratory Sample size SARS-CoV-2 screened secondary outcome Secondary outcomes Seizure serum Seven Severe acute respiratory syndrome single-center standard treatment status Study protocol the Faculty therapeutic treatment arm trial protocol Trial registration Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha two group two groups underlying diseases university Version Warfarin web-based system website X-ray
[DOI] 10.1186/s13063-020-04737-w PMC 바로가기 [Article Type] Letter

The Association Between BMI and Inpatient Mortality Outcomes in Older Adults With COVID-19

Infectious Disease

Published on 2020-10-262022-10-31
Journal: Cureus [Category] COVID-19,

The clinical effect of Nano micelles containing curcumin as a therapeutic supplement in patients with COVID-19 and the immune responses balance changes following treatment: A structured summary of a study protocol for a randomised controlled trial

COVID-19 환자의 치료 보조제로 커큐민을 함유한 나노 미셀의 임상 효과 및 치료 후 면역 반응 균형 변화: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2020-10-222022-08-13
Journal: Trials [Category] MERS, SARS, 임상,

[키워드] 1:1 accompany addition allergy assigned balance Bandar Abbas bedtime blind Blinding both groups breakfast Capsule change Characteristics chronic chronic obstructive pulmonary disease clinical Clinical effect clinical examination clinical examinations clinical symptom clinical trial clinical trials Comorbidities Comorbidity company comparator Complete computer conducted congestive heart failure control group COVID-19 COVID-19 patient COVID-19 patients Curcumin Cytokines digit digits dinner dissemination Effectiveness element evaluate evaluated expected expression filtration filtration rate FOXP3 gallstone gastritis GATA Gender Gene Expression glomerular filtration rate heart failure history IFN-γ IL-17 IL-4 immune response immune responses in both group inclusion criteria Inflammatory marker inflammatory markers information Interleukins intervention group Iran kPa Laboratory laboratory findings laboratory technician laboratory technicians lactation less liver liver failure Lymphocytes number Nurses objective Obstructive obstructive pulmonary disease outcome PaO2 parallel group participant Participation Patient patients patients with COVID-19 per day performed Peripheral blood physician Placebo placebo group placebo-controlled positive COVID-19 post treatment Pregnancy protocol pulmonary disease random randomisation randomised randomised controlled trial randomization Randomized randomized clinical trial Randomly real time PCR recorded recruitment Registered registry Regulatory renal renal failure routine standard treatment Sample size sealed selected serum cytokine serum cytokines Serum level serum parameter serum parameters shift single-center statisticians Study protocol T helper TGF-β the placebo group therapeutic Treatment Trial Trial registration ventilator Version website written consent
[DOI] 10.1186/s13063-020-04824-y PMC 바로가기 [Article Type] Letter