Influenza A Virus Neuraminidase Protein Enhances Cell Survival through Interaction with Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) Protein *Article Published on 2012-04-272023-08-30 Journal: The Journal of Biological Chemistry [Category] E형 간염, [키워드] AKT Cancer neuraminidase SRC Viral protein virus entry [DOI] 10.1074/jbc.M111.328070 PMC 바로가기
Transport of Influenza Virus Neuraminidase (NA) to Host Cell Surface Is Regulated by ARHGAP21 and Cdc42 Proteins *Article Published on 2012-03-232023-06-23 Journal: The Journal of Biological Chemistry [Category] 신종인플루엔자, [키워드] Actin ARHGAP21 Cdc42 GTPase Influenza virus membrane transport neuraminidase Protein Transport Viral protein [DOI] 10.1074/jbc.M111.312959 PMC 바로가기
SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA CleavageResearch Article Published on 2011-12-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 40S accelerated accompany acute respiratory syndrome Antiviral Author bind binding block cells characterized circumvent classical cleavage cleavage sites coronavirus cricket paralysis viruses Degradation demonstrated different element elements events exhibited facilitate Fever found function Hepatitis Host host gene expression host genes host mRNA host protein in vitro induce infected cells Infection inhibitor leader sequence Modification mRNA mRNAs nucleotide nucleotide sequence Protein protein synthesis recognize reporter Resistant ribosome RNA RNA modification SARS Coronavirus SARS infection severe severe symptom subunit suppress the expression susceptible translation type I type I interferon unique viral mRNA Viral protein virus virus replication [DOI] 10.1371/journal.ppat.1002433 PMC 바로가기 [Article Type] Research Article
The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus InhibitorsResearch Article Published on 2011-10-272022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Activation acute respiratory syndrome anti-infective drug Antiviral antiviral target approach Author automated Bacteria binding blocked common cold viruses CoV CoV-229E CoVs cyclophilin cyclosporin A Cytokine dysregulation demonstrated derivative different drug element Epidemics Factor FKBP1A FKBP1B fungi Host host cell host protein Human identification identify Immune cell include induce Infection Infectious Bronchitis Virus inhibited inhibitor Interaction interaction partner interleukin 2 involved led to maintain metabolism modulate Neurological disease non-structural protein nsp1 organism outbreak overlap parasites pathogen Pathogenesis pathway PPIA PPIB PPIG PPIH Protein Replication SARS-CoV severe SARS suggested Systems biology target targets tested Vaccine Viral protein virus virus replication Virus-host interaction viruses [DOI] 10.1371/journal.ppat.1002331 PMC 바로가기 [Article Type] Research Article
In Vitro Reconstitution of SARS-Coronavirus mRNA Cap MethylationResearch Article Published on 2010-04-222022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 Activation activity acute respiratory syndrome addition Author CAP cellular mRNA Complete complex coronavirus Coronaviruses CoV Critical drug design enzyme etiological agent event expression generate Genome host cell in viral in vitro inactive include induce infected cell Influenza virus inhibition assay initiated involved membrane-bound methylated Methylation methyltransferase mRNA mRNAs Mutation non-structural protein nsp14 predicted produced Protein replicate ribosomes RNA RNA genome RNA synthesis RNA transcript S-adenosyl-L-methionine SARS-coronavirus SARS-CoV SARS-CoV infected cells selective sequence target translation variety viral mRNAs viral nonstructural proteins Viral protein virus [DOI] 10.1371/journal.ppat.1000863 PMC 바로가기 [Article Type] Research Article
Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV ReplicationResearch Article Published on 2008-10-012022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] adopted assays biochemical complex coronavirus Coronavirus replication detected domain expressing found function in vitro Interaction Involvement mammalian mechanism molecular mechanisms multifunctional Nidovirale non-structural protein Nsp12 nsp14 Nsp3 platform Protein protein-protein interaction Proteins provided regulate reporter RNA genome SARS Coronavirus SARS-CoV sequence shown stimulated to screen Transcription unique Viral protein viruses [DOI] 10.1371/journal.pone.0003299 PMC 바로가기 [Article Type] Research Article
Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infectionShort Report Published on 2007-06-072022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] affected appear blocking coronavirus COX Cyclooxygenase different different cells early stage Infection inhibitor investigated MHV mouse hepatitis mouse hepatitis virus Pathogenesis progeny reduced Replication required RNA interference subsequent therapy viral infection Viral protein Viral RNA virus production [DOI] 10.1186/1743-422X-4-55 PMC 바로가기 [Article Type] Short Report
Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and SArticle Published on 2007-03-012022-10-06 Journal: Antiviral Research [Category] 진단, [키워드] accessory proteins acute respiratory syndrome aspecific assay coronavirus demonstrated Efficiency eight expressing expression full-length Genome genomic indirect immunofluorescence infected cell inhibit inhibition knockdown mRNA not affected nucleocapsid protein nucleotide Open reading frame ORF ORFs progeny Protein Proteins reduction in Replication RNA SARS CoV SARS-CoV sgRNA sgRNAs siRNA siRNAs specificity tested translated Vero E6 cell viral infection Viral protein virus were infected without affecting [DOI] 10.1016/j.antiviral.2006.10.008 PMC 바로가기 [Article Type] Article
The Severe Acute Respiratory Syndrome (SARS)-coronavirus 3a protein may function as a modulator of the trafficking properties of the spike proteinHypothesis Published on 2005-02-102022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] addition biochemically Cell Coronaviruses cytoplasmic cytoplasmic tail decrease different domain Effect examined expressed expression genetics Genome homologue Hypothesis Impact in vitro in vivo infected cell Infection Interaction mechanism methodology modulate motif Open reading frame other coronaviruses pathway presentation Protein Replication reported respiratory resulting RNA SARS-CoV severe shown significantly Spike protein Testing the spike protein undergo unique viral infection viral pathogenesis Viral protein viral spread [DOI] 10.1186/1743-422X-2-5 PMC 바로가기 [Article Type] Hypothesis
Ultrastructural Characterization of SARS CoronavirusResearch Published on 2004-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome addition assays bronchiolar characterization composed coronavirus coronavirus-infected cell Critical culture cells cytoplasm death described disease transmission electron electron microscopy Emerging infectious diseases feature granular immunogold techniques In situ In situ hybridization Infected Infection Laboratory nucleocapsid outbreak Particle positive replication complex RNA SARS patient SARS virus severe Severe acute respiratory syndrome severe pneumonia shown specimen Structure subsequent ultrastructure vesicles Viral protein virus isolate [DOI] 10.3201/eid1002.030913 PMC 바로가기 [Article Type] Research