Estimating Risk for Death from Coronavirus Disease, China, January–February 2020Research Published on 2020-06-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, SARS, [키워드] 2019 novel coronavirus disease adjusted affected Case-fatality Ratio CFR China coronavirus coronavirus disease country COVID-19 COVID-19 epidemic cumulative death elevated estimate Healthcare system Hubei Mortality outbreak Public health interventions reached reported respiratory diseases risk SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 severity social distancing the epidemic viruses Wuhan zoonoses [DOI] 10.3201/eid2606.200233 PMC 바로가기 [Article Type] Research
Repurposing chlorpromazine to treat COVID-19: The reCoVery studyResearch article Published on 2020-06-012022-10-05 Journal: L'Encéphale [Category] SARS, 신약개발, [키워드] alleviate Anti-SARS-CoV-2 Activity antiviral activity antiviral properties biodistribution blind Brain caused chlorpromazine Clathrin-mediated endocytosis clinical trial contagiousness Course COVID-19 COVID-19 infection COVID-19 pandemic CPZ developmental exhibit form France ICU care incidence individuals Infection lung multicenter neuroscience objective observation offer Paris Patient Prophylactic PROTECT psychotropic drug Randomized Recentin reduce reported repurposing Repurposing of molecules Respiratory Support Saliva SARS-CoV-2 severity Side effects standard treatment symptomatic therapeutic therapy Tolerance treat Trial virulent [DOI] 10.1016/j.encep.2020.05.006 [Article Type] Research article
An evidence mapping and analysis of registered COVID-19 clinical trials in ChinaResearch Article Published on 2020-06-012022-10-28 Journal: BMC Medicine [Category] COVID-19, SARS, [키워드] “COVID-19 2019 novel coronavirus Analysis antiviral drug antiviral drugs CCT Characteristics China Chinese clinical Clinical data clinical trial collected Control COVID-19 COVID-19 outbreak Critical current distributions division drugs evaluate evaluated Evidence experimental group Glaxo Hypothesis identify imperative information interquartile range Intervention majority median Medicine nucleic acid Patient performed pilot study platform primary endpoints Primary outcome Primary outcomes public health recruit Registered registry Research Result Sample size severity Smith Study design TCM the disease therapy Traditional Trial trials variety WHO WHO ICTRP [DOI] 10.1186/s12916-020-01612-y PMC 바로가기 [Article Type] Research Article
Delayed specific IgM antibody responses observed among COVID-19 patients with severe progressionArticles Published on 2020-06-012022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome analysed antibody Antibody Response BALF Bronchoalveolar lavage fluid China clinical information clinically collected colloidal gold Combination complement coronavirus COVID-19 COVID-19 cases COVID-19 patient Delayed diagnose Diagnosis GICA healthy hospital IgM antibody immunochromatographic assay investigation less Local Patient PCR-based assay performed positive positive rate progression Result RT-qPCR SARS-CoV-2 SARS-CoV-2 IgM sera severe disease severity specific IgM specimen Spread sputum swabs symptom onset the disease virus [DOI] 10.1080/22221751.2020.1766382 PMC 바로가기 [Article Type] Articles
PAS stain based histological classification and severity grading of toenail onychomycosisPAS 염색 기반의 발톱 곰팡이 감염의 조직학적 분류 및 중증도 평가Article Published on 2020-06-012024-08-17 Journal: Medical Mycology [Category] 백선증, [키워드] histological classification Onychomycosis PAS stain severity Treatment
Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19Research Perspective Published on 2020-05-312022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] aging Air pollution cascade cause caused COVID-19 cytokine IL-6 Infection infection rates Inflamm-aging Inflammation Inflammatory Inflammatory cytokine lung metformin mitochondrial molecular morbidity and mortality novel coronavirus SARS-CoV-2 Older outcome overlap pandemic disease Particulate matter pathological Population Prevent proinflammatory prothrombotic risk SARS-COV-2 infection severe COVID-19 severity Signaling therapeutic therapeutic strategy thrombotic Transport Trigger [DOI] 10.18632/aging.103347 PMC 바로가기 [Article Type] Research Perspective
Why does COVID-19 disproportionately affect older people?Review Published on 2020-05-312022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Affect age aging cardiovascular disease Coagulopathy consolidation coronavirus disease cough COVID-19 COVID-19 patient Cytokine release syndrome Cytokine storm death diabete Dyspnea Endotheliitis epigenetic clock explain fatal disease Fever genetic test greater Hospitalization identify immune responses Immunity independent risk factor individual Infection inhibiting life-threatening lung mechanism mechanisms mild illness molecular multiple organ failure obesity Older outcome regulate risk risk of death severity survival syndrome the disease Treatment virus [DOI] 10.18632/aging.103344 PMC 바로가기 [Article Type] Review
SARS‐CoV‐2 coinfections: Could influenza and the common cold be beneficial?Research Article Published on 2020-05-302022-11-01 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] circulation common cold computer modeling creating death examined growth Health care system human metapneumovirus Human rhinovirus implication Influenza Influenza virus mathematical Novel coronavirus pathogen Replication respiratory syncytial virus respiratory viruses SARS Coronavirus SARS‐CoV‐2 second wave severity Spread suppressed the timing virus viruses [DOI] 10.1002/jmv.26098 PMC 바로가기 [Article Type] Research Article
Novel Immunoglobulin Domain Proteins Provide Insights into Evolution and Pathogenesis of SARS-CoV-2-Related VirusesResearch Article Published on 2020-05-292022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Alpha Analysis arising attenuate beta-coronavirus beta-CoV Combination comparable Complete coronavirus coronavirus disease CoV COVID-19 COVID-19 pandemic determinant domain Evolution evolutionary arms race Factor Genome Genomic analysis genomic region Health Host Host immune response host immunity hosts identify immune immune evasion immune pressure Immunoglobulin individual insight macro modulate MOST novel Novel coronavirus ORF1a ORF8 outbreak Pathogenesis pathogenicity predicted Protein Proteins Receptor binding domain Region SARS SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein SARS-like coronavirus scrutiny sequence severity Structural analysis the Spike Transmission unique virus Virus-host interactions viruses widespread [DOI] 10.1128/mBio.00760-20 PMC 바로가기 [Article Type] Research Article
Vitamin D Deficiency and Air Pollution Exacerbate COVID-19 Through Suppression of Antiviral Peptide LL37비타민 D 결핍과 대기 오염은 항바이러스 펩티드 LL37의 억제를 통해 COVID-19를 악화시킵니다Public Health Published on 2020-05-282022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료제, [키워드] acquisition Action African American age Air pollution airway carbon nanoparticles Cathelicidin cathelicidin/LL37 citrullination of peptide cleaved co-morbid condition co-morbid conditions COVID-19 COVID19 cytokine cytokine signaling demonstrated effective exposure to expression generate Genes immune immune system Infection infections influence insufficiency interfere Lung disease microbe microbes modulate modulating modulation morbidity morbidity and mortality outcome Particle Pollution public health threat reduce reduced reducing respiratory Respiratory tract infections risk risk factor Risk factors Safe SARS-CoV-2 severity severity of COVID-19 shown Signaling skin pigmentation smoke stimulate suppression synthesis the disease tobacco smoke Transcription VDD Viral virus viruses Vitamin Vitamin D vitamin D deficiency weakened while [DOI] 10.3389/fpubh.2020.00232 PMC 바로가기 [Article Type] Public Health