Defense – Page 44 – Communicable Diseases Research

The Pilin N-terminal Domain Maintains Neisseria gonorrhoeae Transformation Competence during Pilus Phase Variation

Pilin N-말단 도메인은 Pilus 단계 변이 동안 Neisseria gonorrhoeae 변환 능력을 유지합니다

Research Article

Published on 2016-05-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Autophagy Negatively Regulates Transmissible Gastroenteritis Virus Replication

Article

Published on 2016-03-312022-10-29
Journal: Scientific Reports [Category] Coronavirus,

The Nuclear Immune Receptor RPS4 Is Required for RRS1 SLH1 -Dependent Constitutive Defense Activation in Arabidopsis thaliana

핵 면역 수용체 RPS4는 Arabidopsis thaliana에서 RRS1 SLH1 -의존적 구성 방어 활성화에 필요합니다

Research Article

Published on 2014-10-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence activate Activation Agrobacterium allele Amino acid Analysis Arabidopsis Arabidopsis thaliana Bacterial C-terminal Cell complex conducted Defense disease DNA binding domain dominant downstream effector effectors ENCODE function Genes Genetic genetic screen growth hypotheses identify Immune receptor immune receptors immune responses Immunity inactive insertion leucine loss-of-function mutation loss-of-function mutations mammalian mechanism motif mutant mutants Mutation NLR NLRs nuclear nucleotide overlap pathogen performed plant plants Protein Pseudomona Pseudomonas R genes receptor Recognition recognize required rescued responses RRS1 secretion Signaling significantly temperature transcribed transcriptional transcriptional activation transcriptional change Trigger triggers type III wild type
[DOI] 10.1371/journal.pgen.1004655 PMC 바로가기 [Article Type] Research Article

Introgression from Domestic Goat Generated Variation at the Major Histocompatibility Complex of Alpine Ibex

알파인 아이벡스의 주요 조직 적합성 복합체에서 국내 염소 생성 변이로부터의 이입

Research Article

Published on 2014-06-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] adaptive allele alleles Alpine ibex balancing selection breed carried chromosomal region Clustering coding coding regions Defense Evidence functional gene genetic diversity Genetic polymorphism genetic variability Genetic variation genomes goat Haplotype haplotypes heterozygosity histocompatibility histocompatibility complex homozygous Ibex identify immune system individual introgression investigated involved loci locus Major major histocompatibility complex mechanism MHC non-coding region pathogen Pathogens polymorphism populations provide Research restored sequence sequenced Sequencing signature SNP SNP allele SNP alleles species Support susceptible thought two allele Two alleles Variation
[DOI] 10.1371/journal.pgen.1004438 PMC 바로가기 [Article Type] Research Article

Genetic Mapping of Specific Interactions between Aedes aegypti Mosquitoes and Dengue Viruses

이집트숲모기(Aedes aegypti Mosquitoes)와 뎅기열 바이러스(Dengue Viruses) 간의 특정 상호작용의 유전적 매핑

Research Article

Published on 2013-08-012022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Aede assigned Author contribute correlation Critical Defense defense mechanisms Dengue dengue virus dengue viruses detected determine discriminatory power explained Factor Factors G×G interaction G×G interactions Genetic genetic architecture genetic factors genetic loci genetic mapping Genome Genotype Health Host host-pathogen interaction immune responses Interaction interactions invertebrate invertebrates isolate loci mapped mapping marker mechanism mechanisms molecular mechanism molecular mechanisms Mosquito mosquito-virus natural population outcome pathogen pathogen genotype pathogen genotypes Pathogens Patient patients phenotype phenotypic phenotypic variation physical Region remained serotype significantly Specific specificity the mosquito Variation vector virus virus isolate viruses
[DOI] 10.1371/journal.pgen.1003621 PMC 바로가기 [Article Type] Research Article

Tetraspanin Is Required for Generation of Reactive Oxygen Species by the Dual Oxidase System in Caenorhabditis elegans

Tetraspanin은 Caenorhabditis elegans의 이중 산화 효소 시스템에 의한 반응성 산소 종의 생성에 필요합니다

Research Article

Published on 2012-09-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation addition aerobic aerobic metabolism aging Analysis association Author biosynthetic biosynthetic pathway Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans cause Cell cell surface cellular cellular component cellular components co-expression collagen Combination complex complexes conjunction conserved Defense deficiency demonstrated dependent on disease DOXA dual elegan enzyme Enzymes Evidence experiment exposure to Extracellular matrix failure functions Generation Genetic genetic mutation genetics Host host defense hydrogen hydrogen peroxide Imbalance Immunity in vitro in vivo inhibit isozyme less lipids mammalian cells mammals maturation mechanism member metabolism modifications mucosal mutant mutants Mutation NADPH NADPH oxidase nucleic acids Oxidase oxidative stress oxygen pathway peroxidase physiological produced Protein provide Radiation reactive reactive oxygen species redox state regulated Regulatory required responsible restored ROS Signaling signaling pathway Specy suggested System tetraspanin the cell Thyroid thyroid hormone toxic tyrosine unique UV light
[DOI] 10.1371/journal.pgen.1002957 PMC 바로가기 [Article Type] Research Article

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

Research Article

Published on 2012-02-012022-10-06
Journal: PLoS ONE [Category] 진단,

Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

영장류 게놈에서 새로운 TRIM 유전자에 대한 게놈 저장소 식별

Research Article

Published on 2011-12-012022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] African antiviral gene antiviral genes Author best Biology characterized chromosome chromosome 11 Cluster compared copy number Defense described determine Divergence duplication duplications Evolution expressed found Gene gene cluster Genes Genome genomes Han Chinese HIV Human Human genome human population identification immune system individual innate immune response innate immune system Innate immunity locus majority mechanism MOST natural selection neutralized New pathogen Pathogens positive primate primates question Region reservoir restrict restriction factor retroviral rhesus macaques screened selected Specificities target specificity Tripartite Motif ubiquitin ligase virus recognition viruses young gene
[DOI] 10.1371/journal.pgen.1002388 PMC 바로가기 [Article Type] Research Article

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

Research Article

Published on 2011-08-222022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS,

Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis

인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다

Research Article

Published on 2011-06-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type
[DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article