functions – Page 44 – Communicable Diseases Research

Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis

게놈 전반에 걸친 상위성 분석으로 식별된 저항성, 독성 및 핵심 기계 유전자의 상호 작용 네트워크

Research Article

Published on 2017-02-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증,

Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome

네오센트로미어는 칸디다 알비칸스 염색체를 따라 여러 유전자좌에 염색체 분리 정확도 및 중심체 클러스터링을 제공합니다

Research Article

Published on 2016-09-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Accuracy adaptation addition approach assembly benefit Cancer cancer cell Cancer cells cancers Candida Candida albican Candida albicans caused Cell cell division centromere change Chemotherapy chromosome chromosome 5 chromosome segregation chromosomes Cluster Clustering complexes consequence Contact copy number de novo defined disease DNA DNA sequence drug resistance error rate exhibit function functional functions Gene Expression Genes Genome greater independent independent of instance kinetochore leads Like loci maintain mechanisms Multiple nuclear nucleus observation occur organism protein complex Proteins provide recent reduced Region reorganization required segregation speciation stability Support the cells three-dimensional structure Transcription yeast
[DOI] 10.1371/journal.pgen.1006317 PMC 바로가기 [Article Type] Research Article

The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σ V Activation

항-시그마 인자 RsiV는 리소자임에 대한 박테리아 수용체입니다: 공결정 구조 결정 및 RsiV에 대한 라이소자임의 결합이 σ V 활성화에 필요하다는 입증

Research Article

Published on 2016-09-072022-09-17
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence acting activate activated Activation active site addition Bacteria Bacterial bind binding cascade Cell cell wall cleavage cleave complex crystal structure Defense demonstrated demonstration Determination enzymatic activity enzyme Evidence Factor function functions Gram-positive bacteria inhibit inhibitor initiated innate immune lysozyme many case mutant promoter protease Proteases Protein proteolytic receptor regulated required resistance mechanisms RIP RNA polymerase sensor signal Signal transduction specificity Structure suggested susceptible Target genes the cell These data thought Trigger triggering triggers X-ray
[DOI] 10.1371/journal.pgen.1006287 PMC 바로가기 [Article Type] Research Article

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

T 세포 수용체 신호 분자 Vav1의 천연 변이체는 이펙터 T 세포 기능과 신경 염증에 대한 감수성을 모두 감소시킵니다

Research Article

Published on 2016-07-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation Affect alteration Antigen antigen receptor Autoimmune candidate gene CD4 T cell CD4 T cells changes in chromosome 9 Control cytokine cytokine production Cytokines Diseases effector effector T cell effector T cells FOXP3 function functions Genetic genetic study GM-CSF guanine highlight IFN-γ IL-17 immune system immunization Inflammatory cytokine Inflammatory cytokines intrinsic leads locus mechanism mice MOG molecule natural Neuroinflammation Non-synonymous normal enzymatic activity nucleotide peptide phenotype physiological polymorphism Polymorphisms proportion Quantitative receptor reduce reduced Regulatory T cell regulatory T cells Signaling susceptibility T cell T cell receptor T cells Th1/Th17 These data transducing Treg variant Vav1
[DOI] 10.1371/journal.pgen.1006185 PMC 바로가기 [Article Type] Research Article

Systems Level Analyses Reveal Multiple Regulatory Activities of CodY Controlling Metabolism, Motility and Virulence in Listeria monocytogenes

시스템 수준 분석을 통해 Listeria monocytogenes에서 대사, 운동성 및 독성을 제어하는 CodY의 여러 조절 활동이 밝혀졌습니다.

Research Article

Published on 2016-02-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] actA activate activator activity adaptation Affect Amino acid amino acids Analysis Bacteria bacterial pathogen Bacterial pathogens BCAA bind binding branch CodY condition conditions controlling dependent on DNA DNA binding environmental cues expression facilitate function functions Gene Expression Genes Genome gram Gram-positive bacteria growth Host identify identifying L . monocytogene Level Ligand ligands Listeria Listeria monocytogene Listeria monocytogenes mammalian metabolic genes metabolism modulate motility Multiple multiple pathway multiple pathways observation pathogen Pathogens pathway Pathways performed previous study prfA raised regulated regulator gene Regulatory regulatory network reported repress repressor respond response responses Sequencing Stress stress responses System Target genes thought traits Transcription transcription factor transcription factors virulence virulence gene virulence genes
[DOI] 10.1371/journal.pgen.1005870 PMC 바로가기 [Article Type] Research Article

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

Research Article

Published on 2015-11-062022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] affecting Amino acid amino acid change amino acid residue appear ATCC cDNA Central nervous system characterized cleavage cleavage site clone CNS colds contribute convertase coronavirus degenerative demonstrated dissemination Encephalitis etiologies feature functional functions furin-like cleavage site generate Genes glycoprotein HCoV-OC43 Human human respiratory tract identify Impact in viral Infection involved isolate isolates Laboratory less mechanism molecular Mutation nervous neurodegenerative Neuroinvasive neurologic neurological Neurological diseases neurotropic OC43 pathogenic Pathologies pathology Point mutation predominant proportion Proprotein Protein respiratory respiratory pathogen resulting retained S gene S glycoprotein S protein S1 and S2 sequence significantly spike System the S protein variant viral spike virulence virus virus spread while
[DOI] 10.1371/journal.ppat.1005261 PMC 바로가기 [Article Type] Research Article

Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines

Hsp40s는 Hsp104 및 Hsp90 단백질 샤페론 기계의 기능을 지정합니다

Research Article

Published on 2014-10-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

A Lack of Parasitic Reduction in the Obligate Parasitic Green Alga Helicosporidium

절대 기생 녹조류 헬리코스포리디움의 기생 감소 부족

Research Article

Published on 2014-05-082022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Affect Algae animals autotrophy biological function Biological functions categories Cell cell wall chitinases chitinous Chlorella comparable Complete complexes contraction early stage early stages Evidence Evolution example expression extreme Families function functional functions gene families gene family Genome genome maintenance genomic green Helicosporidium Host hosts infection mechanism loss of function majority malaria metabolic function molecular analysis molecular mechanisms nuclear Obligate organism Other outcome parasites parasitism photosynthesis Plasmodium predicted predominant preserved reduction retained sequenced the cell took place Transcriptome transition
[DOI] 10.1371/journal.pgen.1004355 PMC 바로가기 [Article Type] Research Article

Temperate Phages Acquire DNA from Defective Prophages by Relaxed Homologous Recombination: The Role of Rad52-Like Recombinases

온대 파지는 이완된 상동 재조합에 의해 결함 있는 프로파지로부터 DNA를 획득한다: Rad52-유사 재조합효소의 역할

Research Article

Published on 2014-03-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] acquisition addressed Bacteria Bacterial bacterial virus bacterial viruses bacteriophage bacteriophages Bioinformatics analysis biosphere catalyzed comparison complementary contribute defective prophages dependent on Divergence DNA dormant dormant state E. coli Efficiency element Escherichia coli Evidence evidence of Evolution exchange functions gene exchange gene exchanges gene transfer Genetic genetic determinant genetic determinants genetic diversity genetic exchanges Genome genomes genomic Homologous recombination homologous recombination enzymes horizontal gene Horizontal gene transfer Hypothesis in vivo Infection lambdoid phage lambdoid phages majority mechanism molecular mechanisms mosaicism no evidence of phage phage encoded recombinase phage encoded recombinases phage gene phage genome phage λ phages phenotype promote prophage prophages Rad52 RecA REcombinase recombinases Recombination replicate role sequence sequence homology sequences subject Temperate bacteriophage Temperate bacteriophages temperate phage temperate phages transfer virulence virulent virulent phages viruses vivo assays
[DOI] 10.1371/journal.pgen.1004181 PMC 바로가기 [Article Type] Research Article

Analysis of Meiosis in SUN1 Deficient Mice Reveals a Distinct Role of SUN2 in Mammalian Meiotic LINC Complex Formation and Function

SUN1 결핍 마우스의 감수분열 분석은 포유류 감수분열 LINC 복합체 형성 및 기능에서 SUN2의 뚜렷한 역할을 보여줍니다

Research Article

Published on 2014-02-272022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,