Worse Disease Prognosis Is Associated to an Increase of Platelet-Derived Extracellular Vesicles in Hospitalized SARS-CoV-2 Patients더 나쁜 질병 예후는 입원한 SARS-CoV-2 환자에서 혈소판 유래 세포외 소포의 증가와 관련이 있습니다Article Published on 2022-07-072022-09-11 Journal: Disease Markers [Category] COVID19(2023년), SARS, 치료기술, [키워드] applied Biomarker Blood circulating Cohort COVID-19 enrolled Evolution EVs extracellular vesicle Extracellular vesicles flow cytometry healthy controls heparin Hospital admission Hospitalization human diseases increase Italy not affected occurred outcome Patient patients Platelet predict reducing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients steroid Steroids suggested the disease Treatment viral infections WHO guidelines [DOI] 10.1155/2022/8074655 PMC 바로가기 [Article Type] Article
A 51-Year-Old Woman With Interstitial Lung Disease and Subsequent COVID-19 Presenting With Worsening DyspneaCase report Published on 2022-07-062022-10-05 Journal: Chest [Category] 변종, 유전자 메커니즘, [키워드] airway BAL bronchoscopy Care Chest CT COVID-19 cultures defined Diagnosis diffusing Dyspnea foamy macrophage foamy macrophages functional ground-glass opacity Hospitalization Hospitalized ILD impairment Inconclusive interlobular septal thickening Interstitial lung disease intralobular lung Lung disease Mild Moderate COVID-19 Patient presentation presenting Pulmonary function testing Result Shortness of breath specimen table transbronchial transfer video-assisted thoracoscopic surgery woman worsening [DOI] 10.1016/j.chest.2022.01.059 [Article Type] Case report
Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatmentResearch article Published on 2022-07-062022-10-05 Journal: Molecular Therapy [Category] 바이오마커, 변종, 임상, 치료기술, 치료법, [키워드] ACE2 activity/concentration biomarker in plasma/saliva soluble Angiotensin-Converting Enzyme 2 ACE2 acute respiratory syndrome age angiotensin-converting-enzyme Autopsy Biomarker clinical observation Concentration condition Control convalescent Corona virus coronavirus disease Coronavirus-2 COVID-19 COVID-19 disease COVID-19 patient disease disease severity dysregulation evaluate evaluated Hospitalization hospitalized COVID-19 patient human cell infect inverse correlation lung mACE2 marker membrane nadir no difference Non-COVID-19 offer Patient patients plasma Plasma marker plasmas quantitative test quarantine RAS pathway receptor reduced renin-angiotensin system restored sACE2 Saliva saliva marker SARS-CoV-2 SARS-CoV-2 diagnosis/treatment soluble ACE2 statistically therapeutic target tissue treat variations volunteers [DOI] 10.1016/j.omtm.2022.07.003 [Article Type] Research article
Modeling the Impact of Vaccination on COVID-19 and Its Delta and Omicron Variants코로나19와 델타 및 오미크론 변종에 대한 백신 접종의 영향 모델링Article Published on 2022-07-062022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] calculate compartmental model condition confirmed COVID-19 case COVID-19 COVID-19 pandemic cumulative Delta delta variant disease effective example herd immunity Herd immunity threshold Hong Kong Hospitalization hospitalized COVID-19 Immunity Impact individuals initial Isolation modeling omicron Omicron variant parameter proportion reduced reproduction numbers SARS-CoV-2 virus Spread Strains SVEIHR model the SARS-CoV-2 virus vaccinated individual vaccinated individuals vaccination vaccination rate Vaccine variants [DOI] 10.3390/v14071482 PMC 바로가기 [Article Type] Article
Critically ill COVID-19 patients with neutralizing autoantibodies against type I interferons have increased risk of herpesvirus diseaseI형 인터페론에 대한 자가항체를 중화하는 중환자 COVID-19 환자는 헤르페스 바이러스 질병의 위험이 증가했습니다Article Published on 2022-07-052022-09-12 Journal: PLoS Biology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% confidence interval age Analysis anatomical antiviral action autoantibodies autoantibody caused clinical outcomes CMV Cohort coronavirus 2 COVID-19 COVID-19 cohort COVID-19 patient Critically ill critically ill patients deficiency early diagnosis exacerbate Gender healthy donors herpes simplex herpesvirus disease herpesviruses heterogeneity Hospitalization ICU IFN IFNs IgA IgG IgG level IgM increased risk Infection intensive care likelihood longitudinal Neutralizing Odds ratio one patient Patient plasma predict predisposition respiratory SARS-CoV-2 screened steroid treatment Stratification suffered Switzerland tested tracheobronchial secretions Treatment type I interferon virus [DOI] 10.1371/journal.pbio.3001709 PMC 바로가기 [Article Type] Article
Protection of hamsters challenged with SARS-CoV-2 after two doses of MVC-COV1901 vaccine followed by a single intranasal booster with nanoemulsion adjuvanted S-2P vaccineMVC-COV1901 백신 2회 접종 후 SARS-CoV-2에 감염된 햄스터 보호 및 나노에멀젼 보조제 S-2P 백신이 포함된 단일 비강 내 부스터Article Published on 2022-07-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] alum booster booster vaccination country COVID-19 COVID-19 vaccine COVID-19 vaccines CpG1018 death Delta disease dose elicit followed by hamster Hospitalization Immunity immunization immunogenicity Infection intramuscular intranasal Lung pathology medical need mucosal offer omicron Pandemics Patient prefusion problem promote protection protective immunity protocol reduced regimen respiratory respiratory tracts resurgence robust S-2P SARS-CoV-2 SARS-CoV-2 spike severe COVID-19 severe disease solution Transmission vaccination Vaccine variants variants of SARS-CoV-2 Viral viral challenge viral clearance viral infection waning immunity weight loss were used [DOI] 10.1038/s41598-022-15238-y PMC 바로가기 [Article Type] Article
ACTIVATE-2: A Double-Blind Randomized Trial of BCG Vaccination Against COVID-19 in Individuals at RiskACTIVATE-2: 위험에 처한 개인에서 COVID-19에 대한 BCG 백신 접종의 이중 맹검 무작위 시험Randomized Controlled Trial Published on 2022-07-052022-09-12 Journal: Frontiers in Immunology [Category] MERS, 임상, 진단, [키워드] 1:1 95% CI acute respiratory syndrome Against anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies approach Bacillus BCG BCG vaccination benefit clinical criteria Comorbidities controls coronavirus coronavirus disease COVID-19 COVID-19 pandemic develop Diagnosis double-blind trial Efficacy eight elderly vaccination end point evaluated Follow-up Hospitalization Immunity incidence of COVID-19 individual Infection Intervention Laboratory MOST multicenter Occurrence Older participant Patient patients older Placebo positive Randomized recipient reduced reduction respiratory infections Result risk SARS-CoV-2 the placebo group trained immunity Trial vaccination Vaccine Volunteer [DOI] 10.3389/fimmu.2022.873067 PMC 바로가기 [Article Type] Randomized Controlled Trial
COVID-19 vaccination efficacy in numbers including SARS-CoV-2 variants and age comparison: a meta-analysis of randomized clinical trialsSARS-CoV-2 변이체 및 연령 비교를 포함한 숫자로 보는 COVID-19 백신 접종 효능: 무작위 임상 시험의 메타 분석Meta-Analysis Published on 2022-07-032022-09-11 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] 95% CI age Analysis analyzed caused clinical examination clinical trial clinical trials Cohort Coronavirus infection COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines databases death decrease Effect effective Efficacy group groups Hospitalization hospitalizations Infection Meta-analysis Mortality New new SARS-CoV-2 Prevent randomized clinical trial Relative risk required risk SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 severe infections symptomatic text the vaccine vaccination Vaccine variants variants of SARS-CoV-2 was used [DOI] 10.1186/s12941-022-00525-3 PMC 바로가기 [Article Type] Meta-Analysis
Characterization of persons with reported SARS-CoV-2 infection in the Oklahoma City tri-county area: Evidence from the first 12 months of transmissionArticle Published on 2022-07-012023-07-08 Journal: American journal of infection control [Category] COVID19(2023년), [키워드] Comorbidities COVID death demography Hospitalization Oklahoma city SARS-CoV-2 Symptoms [DOI] 10.1016/j.ajic.2022.03.007 PMC 바로가기
Low antispike antibody levels correlate with poor outcomes in COVID-19 breakthrough hospitalizations낮은 안티스파이크 항체 수준은 COVID-19 획기적인 입원의 나쁜 결과와 상관관계가 있습니다Article Published on 2022-07-012022-09-11 Journal: Journal of internal medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 1:1 Analysis analyzed antibody Antibody titer Antibody titers antispike antibodies Chain Reaction Comorbidity confounders correlation COVID-19 cut-off value Delta delta variant hospital Hospitalization Hospitalized hospitalized patient ICU ICU care immunization immunization programs Indicator intensive care intensive care unit LOS Mayo Clinic mechanical ventilation median Mortality Older outcome Patient patients polymerase chain polymerase chain reaction poor prognosis positive propensity score matching recipient replacement retrospective cohort study risk factor SARS-CoV-2 SARS-CoV-2 spike protein significantly solid organ solid organ transplant Spike protein U/mL vaccination Vaccination Status Vaccine Vaccine breakthrough variant while with COVID-19 [DOI] 10.1111/joim.13471 PMC 바로가기 [Article Type] Article