Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice신생아 과산소증은 생쥐에서 SARS-CoV-2 수용체의 연령 의존적 발현을 향상시킵니다Article Published on 2020-12-282022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, [키워드] ACE2 age airway alveolar angiotensin angiotensin converting enzyme AT2 Birth blocked Cell cells Club cells co-morbidities COVID-19 DNA damage Endothelial cell endothelial cells ENhance enzyme epithelial explain exposure to Express expression expression of SARS-CoV-2 greater help hyperoxia increase Increased increased expression Infection Influenza influenza A influenza A virus lung Lung disease mice mitochondrial morbidities oxidative stress oxygen receptor reduced reducing respiratory Respiratory system models Respiratory tract diseases respiratory viral infections risk SARS-CoV-2 receptors Serine severity severity of COVID-19 stimulated Superoxide the SARS-CoV-2 TMPRSS2 transmembrane Viral [DOI] 10.1038/s41598-020-79595-2 PMC 바로가기 [Article Type] Article
COVID-19 and Oxidative StressReview Published on 2020-12-282023-06-14 Journal: Biochemistry. Biokhimiia [Category] MERS, SARS, [키워드] COVID-19 Cytokine storm Endothelium oxidative stress SARS-CoV-2 [DOI] 10.1134/S0006297920120068 PMC 바로가기 [Article Type] Review
Improvement of Executive Function after Short-Term Administration of an Antioxidants Mix Containing Bacopa, Lycopene, Astaxanthin and Vitamin B12: The BLAtwelve StudyArticle Published on 2020-12-272023-08-30 Journal: Nutrients [Category] E형 간염, [키워드] antioxidants astaxanthin Bacopa Cognitive function Lycopene oxidative stress vitamin B12 [DOI] 10.3390/nu13010056 PMC 바로가기 [Article Type] Article
Calming the (Cytokine) Storm: Dimethyl Fumarate as a Therapeutic Candidate for COVID-19Perspective Published on 2020-12-262022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Anti-inflammatory anti-oxidative approved candidate COVID-19 death dimethyl fumarate distress fumarate hospitalisation hyperinflammation immune dysregulation immunomodulatory incidence multiple sclerosis Nrf2 oxidative stress Pathogenesis Severe case severe COVID-19 Spread the cytokine storm therapeutic option Therapeutics urgency Vaccine viable treatment while [DOI] 10.3390/ph14010015 PMC 바로가기 [Article Type] Perspective
Computational and network pharmacology analysis of bioflavonoids as possible natural antiviral compounds in COVID-19Research article Published on 2020-12-232022-10-05 Journal: Informatics in Medicine Unlocked [Category] 치료제, [키워드] amentoflavone Analysis Antiviral Bioflavonoid Bioflavonoids complexes Compound COVID-19 docking Dynamics Effectiveness endoribonuclease glycyrrhizic acid In-silico study Inflammation inhibiting leukocyte Ligand MAPK MERS Middle East modulation molecular molecular docking Molecular docking study Molecular dynamics simulation Mulberroside natural antiviral network pharmacology Novel Coronavirus-2 oxidative stress p53 performed plant protease protein-ligand Proteins RBD respiratory S protein SARS CoV-2 SARS-CoV-2 protein selected signaling pathway Spike protein target proteins the receptor-binding domain therapy TNF trajectory transendothelial migration Treatment Wnt [DOI] 10.1016/j.imu.2020.100504 [Article Type] Research article
Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumoniaReview Published on 2020-12-212022-10-29 Journal: Inflammation research : official journal of the Eu [Category] COVID-19, SARS, [키워드] α-Lipoic acid acute infections anti-inflammatory actions antioxidant applied article Biomarkers Carnitine chronic disorders clinical trials coenzyme Q10 cofactor Combination complementary conditions CoQ10 COVID-19 COVID-19 pandemic demonstrated disorder disorders effective Endpoint Evidence in vitro inflammatory disorder information mitochondrial oxidative stress pathologic Pneumonia Potential proinflammatory Protective provided Result retrieved searched Sepsis therapy Trial [DOI] 10.1007/s00011-020-01423-0 PMC 바로가기 [Article Type] Review
SARS-CoV-2 and Other Respiratory Viruses: What Does Oxidative Stress Have to Do with It?Review Article Published on 2020-12-212022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Affect antioxidant antiviral response antiviral therapy cellular characterized Compound coronavirus COVID-19 pandemic Inflammatory information knowledge mechanism Other oxidative pathway oxidative stress pathophysiology reactive reactive oxygen specy respiratory respiratory viral infections responses SARS-CoV-2 therapeutic targets viral infection viral infections viral pathogenesis [DOI] 10.1155/2020/8844280 PMC 바로가기 [Article Type] Review Article
Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial성인의 중증 COVID-19 치료를 위한 분무형 계면활성제(COV-Surf): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Randomized Controlled Trial Published on 2020-12-102022-09-10 Journal: Trials [Category] MERS, SARS, 비임상, 임상, [키워드] 1080 24 hour 24 hours 48 hour 48 hours ACE2 ADEs administration Adverse adverse event adverse events AEs ALEA All participant All participants allergy alveolar angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anticipated attending physician bind Blinding block randomization Blood bovine breath buffer calcium cells cellular cholesterol Chronic kidney disease class clinical Clinical improvement clinical trial clinical trials Cohort Combination comparator Compliance Concentration conducted Consent contraindication contributing to Control control arm controls COVID-19 COVID-19 adult patient COVID-19 patients current cytokine Data collection Data monitoring committee death declined defined delivery described Device dialysis discretion dissemination dose drug Effect Efficacy EGFR element Eligible participants end point End-Expiratory Pressure Endotracheal intubation enrolled Enrollment enrolment epithelial Escalation EudraCT evaluate exclusion exclusion criteria expected fatty Fatty acid feasibility free fatty acid Frequency hospital hospitalised hypoxia impair include inclusion criteria index Inflammatory marker inflammatory markers Inflammatory response intensive care intensive care unit Intervention investigator Kidney disease lack liver liver failure Local lung lung lavage mechanical ventilation mechanical ventilator mechanically ventilated patient mechanically ventilated patients mixture Mortality nebulisation number objective Open-label opinion Ordinal Scale other treatment outcome oxidative stress Oxygenation PaO participant Patient PCR PEEP Phosphatidylcholine phosphatidylethanolamine phosphatidylglycerol phosphatidylinositol phospholipid PIP Placebo plasma Pneumothorax Positive end-expiratory pressure Prevent Primary outcome progression Protein protocol pulmonary compliance pulmonary hemorrhage pulmonary ventilation quantification randomisation randomised randomised controlled trial Randomized Randomized controlled trial reached receive recorded recruitment reduction Registered reported Respiratory failure SAEs Sample size SARS-CoV-2 viral load SARS-CoV-2 virus secondary outcome Secondary outcomes Serious Adverse Events severe COVID-19 severity sphingomyelin Stage Standard Standard of care status Study protocol subject supplementary material surface tension surfactant synthesis tension the WHO tissue damage total sample size tracheal tracheal aspirate Tracheal aspirates transfer Treatment Trial Trial Steering Committee turnover unique university University College London usual standard of care Ventilation Ventilation Index ventilatory support VFD vibrating mesh nebulizer Viral Viral load virus water website weight with COVID-19 worsening [DOI] 10.1186/s13063-020-04944-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Pathophysiology of SARS-CoV-2 in Lung of Diabetic PatientsPhysiology Published on 2020-12-102022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] acute respiratory syndrome affected Angiotensin-converting enzyme Bacterial Betacoronavirus infection cause caused cells changes in Clinical outcome clinical outcomes conditions coronavirus coronavirus disease COVID-19 described diabete Diabetes Mellitus diabetic patient effective Evidence fatality Glucose highlight Infectious disease Inflammation lung metabolism Mortality novel oxidative stress pathophysiological mechanism pathophysiology pathway patients with comorbidity Pneumonia pro-thrombotic proliferation promoted Research responses SARS-CoV-2 SARS-CoV-2 infected patients severity SGLT1 subjects Treatment type I [DOI] 10.3389/fphys.2020.587013 PMC 바로가기 [Article Type] Physiology
Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney InjuryReview Published on 2020-12-072022-10-30 Journal: Molecules [Category] COVID-19, MERS, [키워드] 3CLpro AKI anti-coronavirus activity anti-inflammatory action anti-inflammatory activity antioxidant aspect caused characterized Clinical outcome coronavirus coronavirus disease COVID-19 Critical Critically ill patient death decrease dietary supplement Diseases disorder etiologies Evidence flavonoids Infection Inflammation Inflammatory inflammatory mediator inhibit Kidney injury medicinal plants Middle East Respiratory Syndrome Virus natural products nephroprotective activity organ oxidative stress pathogenesis and development Perspective pharmacological poor prognosis Potential quercetin renal renal function renoprotective activity SARS-CoV SARS-CoV-2 SARS-CoV-2 patients sustained the SARS-CoV-2 Treatment viral infection [DOI] 10.3390/molecules25235772 PMC 바로가기 [Article Type] Review