Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory virusesResearch Article Published on 2017-06-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 24 hours antiviral genes approach can be used caused Cell cellular response changes changes in coronavirus Defense dependent on disease Effect elicited epithelial cell expression Gene Expression Host host gene expression host response hours post-infection in vitro study in vivo Infection influenza A virus lung epithelial cell Lung epithelial cells mechanism mice microarray analysis Mild moderate mounted murine overlapping parameters Pathogenesis peaked respiratory tract respiratory viral infection respiratory viral infections respiratory virus response rhinovirus severity signature tissue remodeling transcription factor transcriptional Treatment type I interferon unique virus virus infection viruses [DOI] 10.1371/journal.pone.0178408 PMC 바로가기 [Article Type] Research Article
Detection of viral respiratory pathogens in mild and severe acute respiratory infections in SingaporeArticle Published on 2017-02-202022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Acute respiratory infection added analysed ARI chain clinical Cohort Community declined decrease detection Diagnosis evaluate excluded faster hospital Influenza Inpatient Inpatients Laboratory Mild multiplex Nasopharyngeal swab Older Participants pathogen PCR performed presenting Prospective Study reaction respiratory virus Respiratory virus infections RT-PCR Severe case Singapore Surveillance tested viral pathogen viral respiratory virus [DOI] 10.1038/srep42963 PMC 바로가기 [Article Type] Article
Performance Evaluation of Allplex Respiratory Panels 1, 2, and 3 for Detection of Respiratory Viruses and Influenza A Virus SubtypesArticle Published on 2016-11-302023-08-30 Journal: Journal of Clinical Microbiology [Category] E형 간염, [키워드] Multiplex real-time PCR Republic of Korea respiratory virus validation [DOI] 10.1128/JCM.02045-16 PMC 바로가기
A Melting Curve-Based Multiplex RT-qPCR Assay for Simultaneous Detection of Four Human CoronavirusesArticle Published on 2016-11-232022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] Acute respiratory infection characteristic clinical clinical samples coronavirus demonstrated detection Detection sensitivity Diagnosis distribution fluorescent HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 hospitalized patient Human human coronaviruses IMPROVE Infection management melting Melting curve melting curve analysis melting temperature (Tm) multiplex quantitative RT-PCR (RT-qPCR) multiplex RT-qPCR primer Rapid respiratory virus RT-qPCR Sequencing Simultaneous SYBR Green I SYTO 9 temperature Treatment was used [DOI] 10.3390/ijms17111880 PMC 바로가기 [Article Type] Article
Standard and AEGIS nicking molecular beacons detect amplicons from the Middle East respiratory syndrome coronavirusArticle Published on 2016-07-122022-11-01 Journal: Journal of virological methods [Category] Coronavirus, MERS, [키워드] activate Amplicon amplification complex component copy detect DNA and RNA downstream eliminated enzyme genetic information IMPROVE Invasion MERS-CoV MERS-CoV RNA Middle East molecular Nicking Nicking molecular beacon nucleotide Older primer respiratory respiratory syndrome coronavirus respiratory virus reverse transcription PCR RT-PCR sensitivity shown Standard Support Synthetic biology nucleotides Viral RNA was used [DOI] 10.1016/j.jviromet.2016.07.008 PMC 바로가기 [Article Type] Article
Frequent Respiratory Viral Infections in Children with Febrile Neutropenia – A Prospective Follow-Up StudyResearch Article Published on 2016-06-162022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] age Chemotherapy children collected Comparisons coronavirus determine febrile neutropenia Fever Fisher’s exact test Follow-up Frequency genotyped infections majority malignancies Mann-Whitney U test median nasopharyngeal aspirate neutropenia objective oncology Patient patient cohorts polymerase chain positive Prospective resolved respiratory respiratory viral infection respiratory virus respiratory viruses Result rhinovirus Sequencing subject tested treated Treatment virus was used were used [DOI] 10.1371/journal.pone.0157398 PMC 바로가기 [Article Type] Research Article
A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory virusesArticle Published on 2016-02-252022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Amino acid Antiviral antiviral activities antiviral activity Antiviral effect binding blocked Cell emerging respiratory viruses Endosomal acidification exhibited H1N1 H3N2 H5N1 H7N9 high-affinity binding in vitro in vivo influenza A virus membrane fusion MERS-CoV peptide prevented Prophylactic respiratory virus Safe SARS-CoV subsequent tested therapeutic agent viral glycoproteins viral particle Viral RNA viral surface virus [DOI] 10.1038/srep22008 PMC 바로가기 [Article Type] Article
Meeting report: 4th ISIRV antiviral group conference: Novel antiviral therapies for influenza and other respiratory virusesArticle Published on 2016-02-092023-06-14 Journal: Antiviral Research [Category] MERS, [키워드] Antiviral Influenza Isirv-AVG respiratory virus [DOI] 10.1016/j.antiviral.2016.01.012 PMC 바로가기 [Article Type] Article
Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABCReview Published on 2016-01-112023-08-29 Journal: Viruses [Category] E형 간염, [키워드] common cold enterovirus Evolution Pathogenesis respiratory virus rhinovirus [DOI] 10.3390/v8010016 PMC 바로가기 [Article Type] Review
Epidemiology of 11 respiratory RNA viruses in a cohort of hospitalized children in Riyadh, Saudi ArabiaShort Communication Published on 2015-12-012022-11-01 Journal: Journal of medical virology [Category] Coronavirus, [키워드] assays caused children Cohort coronavirus Epidemiology Hospitalized Inc Infant Infection influenza A virus investigated less majority métapneumovirus molecular tools Mortality MPV nasopharyngeal aspirates parainfluenza Periodicals Prevalence prevalent respiratory respiratory RNA virus respiratory syncytial virus respiratory virus respiratory viruses Riyadh RSV RT‐PCR Saudi Arabia virus viruses [DOI] 10.1002/jmv.24435 PMC 바로가기 [Article Type] Short Communication