Vitamin D receptor expression and hepcidin levels in the protection or severity of leprosy: a systematic reviewarticle Published on 2017-06-302024-09-01 Journal: Microbes and Infection [Category] 한센병, [키워드] hepcidin leprosy polymorphism protection severity Vitamin D receptor [Article Type] article
Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory virusesResearch Article Published on 2017-06-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 24 hours antiviral genes approach can be used caused Cell cellular response changes changes in coronavirus Defense dependent on disease Effect elicited epithelial cell expression Gene Expression Host host gene expression host response hours post-infection in vitro study in vivo Infection influenza A virus lung epithelial cell Lung epithelial cells mechanism mice microarray analysis Mild moderate mounted murine overlapping parameters Pathogenesis peaked respiratory tract respiratory viral infection respiratory viral infections respiratory virus response rhinovirus severity signature tissue remodeling transcription factor transcriptional Treatment type I interferon unique virus virus infection viruses [DOI] 10.1371/journal.pone.0178408 PMC 바로가기 [Article Type] Research Article
Relative incidence and individual-level severity of seasonal influenza A H3N2 compared with 2009 pandemic H1N1Research Article Published on 2017-05-112023-05-24 Journal: BMC Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] Cohort Influenza Seroepidemiology Severe outcomes severity [DOI] 10.1186/s12879-017-2432-7 PMC 바로가기 [Article Type] Research Article
Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: a randomised, double-blind, placebo-controlled trial남아프리카 공화국의 유아 및 유아에 대한 비경구 P2-VP8-P[8] 서브유닛 로타바이러스 백신의 안전성 및 면역원성: 무작위, 이중 맹검, 위약 대조 시험Articles Published on 2017-05-052022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] 95% CI adjusted adverse event adverse events African approach assigned benefit block Block randomisation Cohort computer-generated different dose different doses dose dose-escalation doses double-blind eligible Endpoint enrolled finding FIVE followed by foundation Frequency funding geometric mean geometric mean titre geometric mean titres groups healthy highest HIV-uninfected homologous hospital IgA IgG IgG seroresponse immunogenic immunogenicity Infant Infants injection Injections Laboratory live oral rotavirus vaccines Local Melinda Gate Melinda Gates Mild neutralising antibody neutralising antibody seroresponse neutralising antibody seroresponses nine non-replicating rotavirus vaccine occurred offer oral rotavirus vaccine oral vaccines parent Parenteral parents participant Placebo placebo group placebo-controlled placebo-controlled trial primary immunogenicity randomisation randomised reaction receiving reduced Registered Research rotavirus rotavirus disease rotavirus vaccination rotavirus vaccine Safety safety analysis safety endpoint Serious Adverse Event Serious Adverse Events Serum IgA seroresponse Serum IgA seroresponses Seven severity South South Africa subunit Subunit vaccine systemic reaction systemic reactions the placebo group those receiving placebo Treatment Trial trivalent vaccination Vaccine was done was used [DOI] 10.1016/S1473-3099(17)30242-6 PMC 바로가기 [Article Type] Articles
Impact of home-based management on malaria outcome in under-fives presenting in a tertiary health institution in Nigeria나이지리아의 3차 의료 기관에 내원한 5세 이하 아동의 말라리아 결과에 대한 가정 기반 관리의 영향Research Published on 2017-05-032024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Home-based malaria management morbidity Mortality Parasitaemia severity [DOI] 10.1186/s12936-017-1836-6 PMC 바로가기 [Article Type] Research
A genetic switch controls the production of flagella and toxins in Clostridium difficile유전자 스위치는 Clostridium difficile의 편모 및 독소 생성을 제어합니다Research Article Published on 2017-03-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate addition antibiotic Bacteria Bacterial Bacterial infection bacterial pathogen cause characterization Clostridium difficile colonization Control Coordinate Course degrade described determinant determine detrimental effect diarrheal diarrheal disease disease early stage Effect engage enzyme epithelial cells Evidence expressed expression Factor flagella flagellar flagellar gene flagellum Gene Expression Gene regulation Genes Genetic growth Host host tissue Impact in vitro inactivation independent independent of Infection intestinal intestinal epithelial cells intestine inversion isolates mechanism motility mRNA Mutagenesis occur Orientation pathogen phase produced promote regulate Regulation regulator Regulatory responsible secrete secreted secretion sequence severity SigD Structure toxin toxins tyrosine upstream virulence virulence factors [DOI] 10.1371/journal.pgen.1006701 PMC 바로가기 [Article Type] Research Article
Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infectionsResearch Article Published on 2017-01-142022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] age antimicrobial agent Antiviral ARMS Barrier formation cetylpyridinium chloride clinical trial Comparisons component conducted Contact coronavirus cough current demonstrated double-blind double-blinded Effectiveness Efficacy enrolled evaluate Frequency Glycerin had no Host individual Influenza Invasion medication mucosa not differ not significant occurred outcome pilot clinical trial placebo group placebo-controlled placebo-controlled clinical trial proof-of-concept clinical trial Prophylaxis Randomized reduced reducing reduction Registered reported representing Result rhinovirus Safe Secondary objective severity significantly sore throat statistically study outcomes study participant Study participants subject supplementary material the placebo group Tolerability treatment of influenza upper respiratory infection vaccination virus detection was reduced Xanthan gum [DOI] 10.1186/s12879-016-2177-8 PMC 바로가기 [Article Type] Research Article
Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trialCD4 세포 수가 μL당 500개 이상인 HIV 양성인 사람의 중증 세균 감염 위험에 대한 항레트로바이러스 요법의 즉각적인 개시 효과: 무작위 대조 시험의 2차 결과 결과Articles Published on 2017-01-052022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI AIDS allergy analysed Analysis Antiretroviral therapy ART assigned average Bacterial Bacterial infection Bacterial infections bacterial pneumonia Bildung caused CD4 cell Cell composite endpoint Cox proportional hazard Cox proportional hazards regression Cutoff death defined described disorder Effect Endpoint enrolled European explained extrapulmonary tuberculosis Factor finding Follow-up foundation funding hazard ratio Hospital admissions Immediate Increases increases in Infectious disease Infectious diseases median Medical Research Council multivariable analysis network neutrophil neutrophil count Patient Pneumonia randomised controlled trial recruited reduce reduced risk Registered required risk secondary outcome severity subgroup subgroups Trial Tuberculosis univariable analysis [DOI] 10.1016/S2352-3018(16)30216-8 PMC 바로가기 [Article Type] Articles
An assessment of the level of concern among hospital-based health-care workers regarding MERS outbreaks in Saudi ArabiaResearch Article Published on 2017-01-032022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] addition addressed Affect affected age Attitude average calculated Care caused concern covariates disease distinct domains Effectiveness effort evaluated FIVE Government HCW HCWs health-care health-care worker hospital hospitals identify majority management MERS MERS coronavirus MERS-CoV MERS-CoV infection Middle East Mortality Multiple National Nurses occurred outbreak outcome participant Patient precautions predictor questionnaire regression analysis reported respiratory Result risk Safe Saudi Arabia severity significantly the disease Travel virus were assessed were used [DOI] 10.1186/s12879-016-2096-8 PMC 바로가기 [Article Type] Research Article
Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India서남인도 3차 진료 센터에서의 말라리아 원충(P. falciparum 및 P. vivax) 환자의 인구통계학적 및 임상 프로필Research Published on 2016-11-252024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Characteristics diagnostics Epidemiology Features Goa MESA-ICEMR severity [DOI] 10.1186/s12936-016-1619-5 PMC 바로가기 [Article Type] Research