A Scoping Review of Moral Stressors, Moral Distress and Moral Injury in Healthcare Workers during COVID-19Review Published on 2022-02-012022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] approach article cause Collection condition conducted Consequences core COVID-19 database distress English event HCW HCWs healthcare healthcare worker Healthcare workers highlight Inclusion initial search Injury lack Moral Moral distress Moral injury offer outcome Pandemics peer-reviewed PsycINFO Quantitative representing Research review selected Stress Stressor stressors Web of Science worker [DOI] 10.3390/ijerph19031666 PMC 바로가기 [Article Type] Review
Screening and identification of B cell epitope of the nucleocapsid protein in SARS-CoV-2 using the monoclonal antibodies단일클론항체를 이용한 SARS-CoV-2의 뉴클레오캡시드 단백질 B 세포 에피토프의 스크리닝 및 동정Article Published on 2022-02-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibody antibody affinity Antibody titer Antibody titers Antigen B cell B-cell B-cell epitope cause cells Characteristics codon coronavirus coronavirus disease COVID-19 ELISA epitope expressed expression Guidance high affinity Host immune response insect cell insect cells linear mAb mAbs modulation monoclonal antibodies monoclonal antibody N gene N protein nucleocapsid nucleocapsid protein overlapped peptide peptides Protein reactivity Replication respiratory RNA SARS-CoV-2 SARS-CoV-2 N protein Screening sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown strain targets the N protein the SARS-CoV-2 Transcription variants variants of concern variants of interest Viral viral pathogenesis virus virus detection VOCs VOIs were used [DOI] 10.1007/s00253-022-11769-6 PMC 바로가기 [Article Type] Article
Nationwide external quality assessment of SARS-CoV-2 nucleic acid amplification tests in Japan일본에서 SARS-CoV-2 핵산 증폭 검사의 전국 외부 품질 평가Article Published on 2022-02-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification automated cause conducted controls coronavirus COVID-19 dependent on detect diagnostics error external quality assessment failure handling highest inherent Japan Laboratory limit of detection molecular nucleic acid nucleic acid amplification nucleic acid amplification testing Other participated performance private sector public health reported respiratory RNA SARS-CoV-2 SARS-CoV-2 nucleic acid severe acute respiratory syndrome Coronavirus [DOI] 10.1016/j.ijid.2021.11.022 PMC 바로가기 [Article Type] Article
Interaction of SARS-CoV-2 with cardiomyocytes: Insight into the underlying molecular mechanisms of cardiac injury and pharmacotherapySARS-CoV-2와 심근세포의 상호작용: 심장 손상 및 약물 요법의 기본 분자 메커니즘에 대한 통찰력Review Published on 2022-02-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 치료제, [키워드] Abnormalities accessory protein accessory proteins ACE2 adopted advent arteries blood cell calcium cardiac cardiac disease cardiac injuries cardiomyocyte cause CD147 circulating complications Coronary arteries COVID-19 COVID-19 patient dysfunction electrical exhibited Express Extracellular vesicles facilitate heart help homeostasis Infection Injury insight integrin Interaction involved Lungs Manifestations manifested mechanism molecular mechanism pathway Pathways pericyte pericytes pharmacotherapy PROTECT Protein receptor reduced Respiratory illness ROS production SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV-2 vaccines severe COVID-19 Side effect Side effects signaling pathway Spectrum subject Support the SARS-CoV-2 TMPRSS2 Treatment Vaccine virus [DOI] 10.1016/j.biopha.2021.112518 PMC 바로가기 [Article Type] Review
The Impact of COVID-19 on Liver InjuryReview article Published on 2022-02-012022-10-05 Journal: The American journal of the medical sciences [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] acute respiratory distress antiviral drug ARDS cause coronavirus disease COVID-19 COVID-19 patients Cytokine storm epidemiological Features global pandemic hepatic injury highlight Hypoxemia Impact Infection Inflammatory Liver damage Liver disease liver dysfunction Liver injury Liver transaminases Lung injury management Mortality outbreak Pathogenesis patients with COVID-19 Prognostic factor Proteins reported SARS-CoV-2 viral severity syndrome the disease [DOI] 10.1016/j.amjms.2021.11.001 [Article Type] Review article
An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection실리코 분석은 SARS-CoV-2 감염에 의해 유발된 사이토카인 폭풍을 잠재적으로 조절하는 약물을 식별합니다Article Published on 2022-01-312022-09-10 Journal: Scientific Reports [Category] 신약개발, 유전자 메커니즘, 치료제, [키워드] “cytokine storm” addition Analysis anti-inflammatory properties anti-inflammatory property approach BALF Bronchoalveolar lavage fluid cause causes Computational biology and bioinformatics connectivity COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 patient Cytokines Data mining dataset drug Effect expected female hormone glucocorticoid Glucocorticoids Health help human cell lines identify immune response immune responses in silico analysis in vitro data Inflammatory Map MEK inhibitor modulating molecules Mortality negative regulation pathology pathway Pathways PKC predicted reveal SARS-CoV-2 SARS-COV-2 infection small molecule Small molecules supported the cytokine storm these compounds Transcription Transcriptome transcriptomic data Treatment triggered [DOI] 10.1038/s41598-022-05597-x PMC 바로가기 [Article Type] Article
Cytomegalovirus pneumonitis amid COVID-19 chaos: the hidden enemy—a case reportCase Report Published on 2022-01-312022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, SARS, [키워드] Active surveillance acute respiratory syndrome Case report cause clinician CMV cohorts connective tissue connective tissue disease coronavirus coronavirus disease Course COVID-19 Cytokine storm cytomegalovirus disease-associated favor female help Herpesviridae hidden higher risk immune dysregulation immune system Immunosuppressed immunosuppressive therapy increasingly infections inhibitor initial innate immune pathway innate immune pathways intensive care Interstitial lung disease interstitial pneumonia knowledge mimicking morbidity and mortality Occurrence overlap Patient Pneumonia reported SARS-CoV-2 severe coronavirus disease thought treated [DOI] 10.1186/s13256-022-03259-0 PMC 바로가기 [Article Type] Case Report
Mesenchymal Stem Cell-Based COVID-19 Therapy: Bioengineering Perspectives중간엽 줄기세포 기반 COVID-19 치료: 생명공학적 관점Review Published on 2022-01-292022-09-11 Journal: Cells [Category] 변종, [키워드] ACE2 acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 bioengineering cause clinical trial clinics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapy genetic engineering Infection Inflammatory diseases Lung injury mesenchymal stem cell Mesenchymal stem cells MSC MSCs offer option pathogenic Perspective pulmonary diseases respiratory respiratory distress SARS-CoV-2 SARS-COV-2 infection STEM syndrome the SARS-CoV-2 therapeutic efficacy therapeutic option therapeutic options therapy TMPRSS2 Treatment variant [DOI] 10.3390/cells11030465 PMC 바로가기 [Article Type] Review
Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome치명적인 COVID-19 폐렴과 다기관 염증 증후군이 있는 어린이의 유전성 IFNAR1 결핍Case Reports Published on 2022-01-282022-09-10 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] autoantibodies autoantibody autosomal recessive candidate gene cause causes Child children contribute COVID-19 COVID-19 pneumonia Critical critical pneumonia Cytokines detect died dysregulation Exome Genetic variant homozygous IFNAR1 IFNAR1 deficiency IFNs Immunity Inborn error inborn errors of immunity (IEI) Inflammatory interferons investigated loss-of-function MIS-C multisystem inflammatory syndrome in children (MIS-C) objective patients Plasma level Plasma levels Pneumonia primary immunodeficiency (PID) raise Result SARS-COV-2 infection Sequencing specific antibodies specific antibody supplementary material syndrome Type I IFN type I IFNs type I interferon type I interferons underlie variant virus was performed [DOI] 10.1007/s10875-022-01215-7 PMC 바로가기 [Article Type] Case Reports
Trends in Disease Severity and Health Care Utilization During the Early Omicron Variant Period Compared with Previous SARS-CoV-2 High Transmission Periods – United States, December 2020-January 2022이전 SARS-CoV-2 높은 전염 기간과 비교하여 초기 오미크론 변이 기간 동안의 질병 심각도 및 의료 이용 추세 - 미국, 2020년 12월-2022년 1월Comparative Study Published on 2022-01-282022-09-11 Journal: Morbidity and Mortality Weekly Report [Category] 변종, [키워드] addition Admission Admissions appear average B.1.1.529 B.1.617.2 Care cause CDC circulating variant clinically Coverage COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient COVID-19 patients Critical database death Delta died disease severity emergency department examined Health Health care Health care system health care systems Health Care Utilization highest hospital Hospital admission Hospital admissions Hospitalization hospitalizations hospitalized COVID-19 patient hospitalized COVID-19 patients hospitals ICU Immunity IMV infections intensive care intensive care unit Invasive mechanical ventilation less Local maximum moving average National nine omicron Omicron variant percentage percentages Period predominant reduce reported SARS-CoV-2 sequenced Severity of disease shown specimen Spread Surveillance the mean the United State The United States Transmission trend United States utilization vaccination variant variant of SARS-CoV-2 virulence virulent virus Volume Winter [DOI] 10.15585/mmwr.mm7104e4 PMC 바로가기 [Article Type] Comparative Study