Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study영국 런던의 신종 SARS-CoV-2 B.1.1.7 계통의 게놈 특성 및 임상 효과: 전체 게놈 시퀀싱 및 병원 기반 코호트 연구Article Published on 2021-09-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] SARS, 변종, 치료기술, [키워드] adjusted age analysed Analysis association B.1.1.7 B.1.1.7 variant Characteristics Clinical effect Clinical severity Cohort cohort study collected college Comorbidities Council Cycle threshold value death defined emergence Engineering epitope Epitopes Ethnicity Evidence evidence of genomic genomic read hospital hospitalised identify Immunocompromised patient Immunocompromised patients inclusion criteria Infection Lineage London mass vaccination monoclonal antibodies Mutation mutations NHS NIHR no evidence of Ordinal Scale Patient patients PCR PCR cycle Poisson regression model Poisson regression models positive Positive test Prevalence raise Remdesivir SARS-CoV-2 SARS-CoV-2 B.1.1.7 Science sequenced Sequencing severe disease Sex specific mutation specific mutations Spike protein Symptom the spike protein the WHO threshold value Transmissibility Trust university vaccination variant variants Viral load Virological virus load VoC WHO ordinal scale whole-genome sequencing [DOI] 10.1016/S1473-3099(21)00170-5 PMC 바로가기 [Article Type] Article
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape탈출에 대한 폭과 저항을 최대화하는 SARS-CoV-2 RBD 항체Article Published on 2021-09-012022-09-12 Journal: Nature [Category] Fulltext, SARS, 변종, 진단, [키워드] ACE2 angiotensin-converting enzyme 2 anti-SARS-CoV-2 antibody antibodies antibody bind binding breadth clade epitope escaped exceptional feature function hamster high affinity highlight identify in vitro Mutation neutralization potency neutralizing antibody Pandemics prophylactically PROTECT Protective RBD RBM receptor-binding motif sarbecovirus SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 RBD the RBD the receptor-binding domain therapeutic understanding Vaccine design Variation viral challenge viral escape viral neutralization [DOI] 10.1038/s41586-021-03807-6 PMC 바로가기 [Article Type] Article
Broad sarbecovirus neutralization by a human monoclonal antibody인간 모노클로날 항체에 의한 광범위한 사베코바이러스 중화Article Published on 2021-09-012022-09-11 Journal: Nature [Category] SARS, 변종, 조류인플루엔자, 진단, [키워드] ACE2 administration angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antigenic antigenic drift antigenic site B.1.1.7 B.1.351 B.1.351 variant B.1.427 B.1.429 binding clade conserved coronavirus cross-react effective epitope hamster highlight Human monoclonal antibody human population in vitro Mesocricetus monoclonal antibody neutralization neutralize Neutralizing antibodies neutralizing antibody not affected P.1 Prevent Prophylactic PROTECT Receptor-binding domain recognize sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selection experiment spike spike-mediated cell entry spikes the receptor-binding domain therapeutic treat Treatment Vaccine variant variants variants of concern zoonotic infections zoonotic sarbecovirus [DOI] 10.1038/s41586-021-03817-4 PMC 바로가기 [Article Type] Article
Intra-host non-synonymous diversity at a neutralizing antibody epitope of SARS-CoV-2 spike protein N-terminal domainSARS-CoV-2 스파이크 단백질 N-말단 도메인의 중화 항체 에피토프에서 숙주 내 비 동의어 다양성Article Published on 2021-09-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] SARS, 변종, 진단, [키워드] Affect Amino acid amino acid residue binding Clusters collected Course COVID-19 COVID-19 patient COVID-19 patients database deep sequencing demonstrated determine epitope Epitopes Frequency Genetic hotspot Illumina Illumina sequencing Infection Intra-host diversity monoclonal antibodies Mutation mutations N-terminal domain Nanopore nanopore sequencing Neutralizing neutralizing antibody neutralizing epitope neutralizing epitopes Non-synonymous Non-synonymous mutation nucleotide Patient performed respiratory respiratory specimen respiratory tract Saliva Sanger sequencing SARS-CoV-2 SARS-CoV-2 spike protein sequence sequenced sequences Sequencing severe disease single nucleotide polymorphisms specimen spike spike gene Spike protein sputum the spike protein therapeutic efficacy Viral viral genome was performed [DOI] 10.1016/j.cmi.2020.10.030 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of ConcernSARS-CoV-2 스파이크 단백질 돌연변이 및 항체 탈출: 우려되는 변이체에서 에피토프 손실의 계산 모델Article Published on 2021-09-012022-09-10 Journal: Journal of Chemical Information and Modeling [Category] SARS, 변종, 진단, [키워드] antibody Antibody binding antibody binding sites applied changes in characterized concern consequence Contact COVID-19 vaccines D614G develop dominant Efficacy elicited epitope Epitopes escape evade glycosylated helping Host immunogenic immunological immunoreactivity Loss Model Modification modifications molecular molecular dynamics mutant mutants Mutation performed predict Protein raise reactivity Recognition recognize reduce Region regions S-protein S-protein variant SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike variants sequence solution spike Structure translate Treatment Vaccine vaccine efficacy Vaccines variant variants Viral viral surface virus while [DOI] 10.1021/acs.jcim.1c00857 PMC 바로가기 [Article Type] Article
Modeling the population effects of escape mutations in SARS-CoV-2 to guide vaccination strategies백신 접종 전략을 안내하기 위해 SARS-CoV-2에서 탈출 돌연변이의 인구 효과 모델링Article Published on 2021-09-012022-09-11 Journal: Epidemics [Category] SARS, 변종, 치료기술, [키워드] accelerated base caused criteria cross-neutralization drifting Effect Effectiveness elicited Endemic Epidemic epitope Epitopes escape escape mutation escape mutations Host Immunity Infection long term modeling mutations neutralization outbreak parameter Population population level Population Transmission System Model provide respond SARS-CoV-2 similarities similarity strain Strains System Vaccination strategy Vaccine Variation waning waning immunity [DOI] 10.1016/j.epidem.2021.100484 PMC 바로가기 [Article Type] Article
Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2Immunology Published on 2021-08-302022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] A475V addition Against antibody Antibody neutralization authentic SARS-CoV-2 virus convalescent COVID-19 patients D614G demonstrated drug epitope exhibited functional mutant mutated mutation resistance NAb neutralization activity neutralization potency Neutralizing activity Neutralizing antibodies neutralizing antibody nine novel pseudovirus RBD binding RBD binding affinity recombined antibody reconstructed SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 neutralizing antibody screened Spike protein Spike proteins systemically therapeutic agent vaccine-induced immune response variant [DOI] 10.3389/fimmu.2021.715464 PMC 바로가기 [Article Type] Immunology
CIDO ontology updates and secondary analysis of host responses to COVID-19 infection based on ImmPort reports and literatureImmPort 보고서 및 문헌을 기반으로 한 COVID-19 감염에 대한 호스트 응답의 CIDO 온톨로지 업데이트 및 2차 분석Research Published on 2021-08-282022-09-10 Journal: Journal of Biomedical Semantics [Category] MERS, 변종, 유전자 메커니즘, [키워드] ACE2 added Analysis benefit binding can be used CIDO Cohort coronavirus Coronavirus infectious disease ontology coronavirus S COVID-19 COVID-19 infection COVID-19 patients cytokine Cytokines Data analysis database development enhancement epitope Epitopes female patient Female patients homology host response host responses Host-coronavirus interaction IL-10 ImmPort immune Infection information Interaction knowledge male mechanisms Metadata molecular Mortality Mutation OBO foundry Ontology overlap pandemic Patient patients performed platform recorded reinforcement reported representing Research response Result S protein S proteins SARS-CoV-2 SARS-CoV-2 viral secondary Sex difference signaling pathway statistically significant Support supported up-regulated variants viral S viral S protein was used [DOI] 10.1186/s13326-021-00250-4 PMC 바로가기 [Article Type] Research
A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2RESEARCH ARTICLE Published on 2021-08-272022-10-30 Journal: National Science Review [Category] COVID-19, [키워드] acute respiratory syndrome animal model Antibody-dependent enhancement Combination Complete concentrations conformational coronavirus COVID-19 convalescent patient Cryo-electron microscopy cryo-EM determinant domain effective Efficacy elicited epitope Immune escape immunization immunized immunogen immunogens Infection injected macaque macaques mitigate monoclonal antibody mononuclear cell N-terminal domain NAbs neutralization potency Neutralizing Neutralizing antibodies neutralizing antibody neutralizing epitope NTD Peripheral blood Protective protective immune response Protein provided RBD RBD domain RBD-targeting NAb Receptor binding domain Result SARS-CoV-2 Screening Spike protein Structure structure-based immunogen design Vaccine design Vaccine development viral escape [DOI] 10.1093/nsr/nwab053 PMC 바로가기 [Article Type] RESEARCH ARTICLE
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker강력하고 광범위한 코로나바이러스 차단제로서의 ACE2 표적 단클론항체Article Published on 2021-08-252022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단, 치료제, [키워드] ACE2 affecting Alanine angiotensin B.1.1.7 B.1.351 B.1.617.1 binding blocked CDR3 clinical development coronavirus Coronaviruses COVID-19 cryo cryo-EM D614G domain Drug development entry receptor epitope Evolution HCoV HCoV-NL63 heavy chain human ACE2 human Angiotensin-converting enzyme in vitro Infection Infectious diseases live SARS-CoV-2 management mice monoclonal antibody multiple coronaviruses mutant non-human primate non-human primates P.1 physiological activities physiological activity Prophylactic provided residue SARS-CoV SARS-CoV-2 SARS-COV-2 infection Toxicity variant virus [DOI] 10.1038/s41392-021-00740-y PMC 바로가기 [Article Type] Article