functions – Page 45 – Communicable Diseases Research

Transcriptional profiling of feline infectious peritonitis virus infection in CRFK cells and in PBMCs from FIP diagnosed cats

Research

Published on 2013-11-092022-10-28
Journal: Virology Journal [Category] Coronavirus,

[키워드] Analysis Apoptosis caused Cell cells CLC bio coronavirus CrFK determinant diagnosed differentially expressed differentially expressed gene disease down-regulated enteric expression expressions FDR Felis FIPV Fold change functions Gene Gene Expression Genes healthy homogeneous host gene expression Illumina Infected infected cell Infection infectious majority mapped MOST mutant PBMC PBMCs PD-L1 peripheral peritonitis post infection produced Rate reference genome regulated Regulation Result RNA sequencing RT-qPCR sequenced sequencing approach significantly statistical analysis Th1 cell transcriptional Transcriptome up-regulated virulence virulent virus virus infection was used
[DOI] 10.1186/1743-422X-10-329 PMC 바로가기 [Article Type] Research

Tetraspanin Is Required for Generation of Reactive Oxygen Species by the Dual Oxidase System in Caenorhabditis elegans

Tetraspanin은 Caenorhabditis elegans의 이중 산화 효소 시스템에 의한 반응성 산소 종의 생성에 필요합니다

Research Article

Published on 2012-09-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation addition aerobic aerobic metabolism aging Analysis association Author biosynthetic biosynthetic pathway Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans cause Cell cell surface cellular cellular component cellular components co-expression collagen Combination complex complexes conjunction conserved Defense deficiency demonstrated dependent on disease DOXA dual elegan enzyme Enzymes Evidence experiment exposure to Extracellular matrix failure functions Generation Genetic genetic mutation genetics Host host defense hydrogen hydrogen peroxide Imbalance Immunity in vitro in vivo inhibit isozyme less lipids mammalian cells mammals maturation mechanism member metabolism modifications mucosal mutant mutants Mutation NADPH NADPH oxidase nucleic acids Oxidase oxidative stress oxygen pathway peroxidase physiological produced Protein provide Radiation reactive reactive oxygen species redox state regulated Regulatory required responsible restored ROS Signaling signaling pathway Specy suggested System tetraspanin the cell Thyroid thyroid hormone toxic tyrosine unique UV light
[DOI] 10.1371/journal.pgen.1002957 PMC 바로가기 [Article Type] Research Article

Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo

Article

Published on 2012-07-202022-11-01
Journal: Virus research [Category] Coronavirus,

A Single Polar Residue and Distinct Membrane Topologies Impact the Function of the Infectious Bronchitis Coronavirus E Protein

Research Article

Published on 2012-05-032022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

SARS Coronavirus 3b Accessory Protein Modulates Transcriptional Activity of RUNX1b

Research Article

Published on 2012-01-122022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] Accessory accessory protein activity acute respiratory syndrome Affect AP-1 binding Cell cells cellular chemokine co-immunoprecipitation cytokine dendritic cells downstream genes elevated ENCODE ERK expressing finding found functions Genome Host IL2 increase in Infected Infection inhibitor Interaction interferon isoform kinase lab led to MIP-1α monocyte mRNA level Pathogenesis pharmacological Phosphorylation physiological promoter Protein recruitment related reporter gene assay Runt RUNX1 SARS Coronavirus SARS virus SARS-CoV target gene transcription factor transcriptional activity Treatment unique upregulated upregulating upregulation yeast
[DOI] 10.1371/journal.pone.0029542 PMC 바로가기 [Article Type] Research Article

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

상호 작용을 위한 게놈 와이드 스크린은 총 콜레스테롤에 대한 허리 대 엉덩이 비율의 영향을 수정하는 4p15에 대한 새로운 위치를 밝힙니다.

Research Article

Published on 2011-10-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] A allele adipose Adipose tissue affected affecting allele approach association Author body composition candidate gene cardiovascular diseases CCKAR characterized cholesterol chromosome circulating Cohort collected Concentration conducted contribute dataset demonstrated described differential expression distribution Effect enrichment epidemiological European explain found functions G allele Gene Gene Expression Genetic variant genome-wide association genome-wide significant genomic Genotype genotypes global health GWA Health heritability homozygous identify individual initial Interaction Intervention joint Lipid lipid metabolism lipids loci locus Low-density lipoprotein Low-Density Lipoprotein cholesterol measure Meta-analysis metabolism modify Modifying New open PCDH7 Phenotypes population-based cohort profiles Ratio recent related Replication reported risk risk factor Risk factors Screen screened serum serum lipid Serum lipids Sex Standard deviation tissue Total Total cholesterol Triglyceride triglycerides variant variants waist waist-to-hip ratio WHR
[DOI] 10.1371/journal.pgen.1002333 PMC 바로가기 [Article Type] Research Article

Annexin A2 Binds RNA and Reduces the Frameshifting Efficiency of Infectious Bronchitis Virus

Research Article

Published on 2011-08-302022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] Annexin Anti-viral AnxA2 bind binding cell proliferation cells cellular cellular mRNAs crosslinking DNA Efficiency Exocytosis functions IBV implicated in vitro involved knockdown metabolism modulate mRNA Protein reduced regulate RNA RNA binding protein shown significantly tested ultraviolet Viral RNA was used
[DOI] 10.1371/journal.pone.0024067 PMC 바로가기 [Article Type] Research Article

Temporal Variability and Social Heterogeneity in Disease Transmission: The Case of SARS in Hong Kong

Research Article

Published on 2009-08-212022-10-28
Journal: PLoS Computational Biology [Category] Coronavirus, MERS,

[키워드] acute respiratory syndrome Affect applied Author average behavioural Better case change changes in Community Contact Course Critical different disease transmission effective Epidemic Epidemics epidemiological estimate event Evolution example functions General population healthcare healthcare worker Hong Kong hospital Hospitalized hospitals infect infectious influenza pandemic Markov chain mean measure observation outbreak parameter parameters Probability PROTECT provided public health measure recent reduced remained Reproduction number risk of infection SEIR shown subpopulation susceptible-exposed-infectious-removed sustained Temporal the SARS epidemic Transmission transmission rates was used were infected
[DOI] 10.1371/journal.pcbi.1000471 PMC 바로가기 [Article Type] Research Article