The Role of Immunological and Clinical Biomarkers to Predict Clinical COVID-19 Severity and Response to Therapy—A Prospective Longitudinal Study임상 COVID-19 심각도 및 치료에 대한 반응을 예측하기 위한 면역학적 및 임상적 바이오마커의 역할 - 전향적 종단 연구Immunology Published on 2021-03-172022-08-31 Journal: Frontiers in Immunology [Category] 바이오마커, 치료제, [키워드] acute respiratory distress syndrome Admission age and sex amplified association baseline Biomarker Blood blood sampling C-reactive protein C-reactive protein (CRP clinical Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity CRP CRP level CRP levels cytokine Cytokine storm Dexamethasone discharge disease disease severity elevated hospital discharge Hospitalized IL-6 interleukin interleukin-6 IQR Kinetics laboratory investigation longitudinal marker NIC non-infectious offer Patient patients patients hospitalized patients treated Predictive Predictive value predictor pro-inflammatory pro-inflammatory markers Prospective recruited reduction Remdesivir response Result role SARS-CoV-2 SARS-CoV-2 positive patient Sepsis serum Serum IL-6 severe coronavirus disease Staphylococcus aureus Staphylococcus aureus bacteraemia the SARS-CoV-2 the strongest timepoints treatment group treatment groups vital sign vital signs was performed [DOI] 10.3389/fimmu.2021.646095 PMC 바로가기 [Article Type] Immunology
Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocolEpidemiology Published on 2021-03-172022-10-28 Journal: BMJ Open [Category] COVID-19, [키워드] analysed Analysis approval asked behavioural catastrophic caused change city Cohort collected COVID-19 determinant dissemination Epidemiology Ethics evaluate Government host immunity household household transmission immune response Immunity Immunological response immunology Infection initial investigated IRAS nasal swab National Health Service nucleic acid amplification participant Participants peer-reviewed positive Prevalence Prospective prospective observational study protocol public health REC reduce Region respiratory infections restrict Result risk factor SARS-CoV-2 SARS-COV-2 infection secondary attack rate severity Spread spread of COVID-19 Stage Study protocol Symptoms tested the disease Transmission transmission of SARS-CoV-2 variables Virology widespread [DOI] 10.1136/bmjopen-2020-048317 PMC 바로가기 [Article Type] Epidemiology
Clustering and longitudinal change in SARS-CoV-2 seroprevalence in school children in the canton of Zurich, Switzerland: prospective cohort study of 55 schools스위스 취리히 주의 학교 아동에서 SARS-CoV-2 혈청 유병률의 클러스터링 및 종단적 변화: 55개 학교의 전향적 코호트 연구Article Published on 2021-03-172022-09-11 Journal: The BMJ [Category] Fulltext, SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age children class Clustering cohort study Community community transmission coronavirus credible interval determine diagnosed District Europe explained Health highest increase in Keeping logistic regression models longitudinal change longitudinal changes moderate no significant differences occurred outcome pandemic parent parents participated preventive measure Prospective prospective cohort study provided questionnaire Questionnaires Randomly reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 seroprevalence School Schools second wave selected serological result serological results Serological testing serology serology test serology tests seronegative seropositive Seropositivity Seroprevalence severe acute respiratory syndrome Coronavirus significant difference Sociodemographic stratified summer Switzerland Symptom the SARS-CoV-2 transmission of SARS-CoV-2 Uncertainty variance variants of SARS-CoV-2 [DOI] 10.1136/bmj.n616 PMC 바로가기 [Article Type] Article
Construction and validation of a machine learning‐based nomogram: A tool to predict the risk of getting severe coronavirus disease 2019 (COVID‐19)머신 러닝 기반 노모그램의 구축 및 검증: 심각한 코로나바이러스 질병 2019(COVID-19)에 걸릴 위험을 예측하는 도구Original Research Published on 2021-03-132022-09-12 Journal: Immunity, Inflammation and Disease [Category] MERS, SARS, 진단, [키워드] 95% CI Analysis applied AUC benefit build C‐reactive protein calibration curve cDCs Clinical characteristics clinical feature clinician Cohort Comorbidity construction coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical Critical illness CRP decision curve analysis develop disease distribution enrolled erythrocyte sedimentation erythrocyte sedimentation rate ESR evaluate facilitate Factor feature filtered FIVE Hospitalization identifying independent internal Lactate lactate dehydrogenase LDH Logistic regression machine learning management Medical resources multivariate multivariate logistic regression nomogram Patient potential risk predict Predictive predictor Prospective prospective cohort receiver operating characteristic Result risk ROC sedimentation rate selected severe coronavirus disease severe COVID‐19 prediction training training set Treatment validation cohort were used [DOI] 10.1002/iid3.421 PMC 바로가기 [Article Type] Original Research
Predictors of hospital-acquired bacterial and fungal superinfections in COVID-19: a prospective observational studyCOVID-19에서 병원 획득 세균 및 곰팡이 중복 감염의 예측자: 전향적 관찰 연구Observational Study Published on 2021-03-122022-09-12 Journal: Journal of Antimicrobial Chemotherapy [Category] 임상, 진단, [키워드] 95% CI accounted Admission Analysis Antibiotics Bacteria Bacterial C-reactive protein caused clinical complicate Course COVID-19 defined drug Factor fungal Fungal infection fungi Hospital admission Hospital stay Hospitalized hospitalized patient identify Immunomodulatory agent intestinal Invasive mechanical ventilation Italy Length median time mortality rate occurred outcome Patient patients patients with COVID-19 polymicrobial infection predictor Prospective prospective observational study Registered risk selected superinfection Treatment university was performed with COVID-19 [DOI] 10.1093/jac/dkaa530 PMC 바로가기 [Article Type] Observational Study
Hypertension and Related Comorbidities as Potential Risk Factors for COVID-19 Hospitalization and Severity: A Prospective Population-Based Cohort StudyArticle Published on 2021-03-122022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI adjusted relative risk Admission aRR cardiovascular disease Cerebrovascular disease Chronic kidney disease chronic kidney diseases Cohort conditions COVID-19 COVID-19 hospitalization COVID-19 mortality death evaluated Factor General population group higher risk Hospitalization Hospitalized hospitalized patient hospitalized patients hypertension identify independent intensive care laboratory-confirmed Mortality outcome Person Poisson regression population-based cohort Potential potential risk Prospective risk SARS-CoV-2 severe cases severe COVID-19 Spanish was used [DOI] 10.3390/jcm10061194 PMC 바로가기 [Article Type] Article
Severe acute respiratory syndrome coronavirus 2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in coronavirus disease 2019 endemic areas: Prospective cross‐sectional study in Japan중증급성호흡기증후군 코로나바이러스 2 코로나바이러스 질환 2019 풍토병 지역에서 위장관 내시경을 받는 환자의 타액 및 위 및 장액 유병률: 일본의 전향적 횡단면 연구Original Article Published on 2021-03-122022-09-11 Journal: Digestive Endoscopy [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed antibody Antibody test Chain Reaction city coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 detectable Early detection Endemic endoscope endoscopy fluids Gastrointestinal gastrointestinal fluid gastrointestinal tract Infection information intestinal Japan medical staff medication no significant differences objective pandemic era Patient patients PCR PCR positive polymerase chain reaction positive positive rate positive result Prevalence Primary outcome Prospective provided Registered respiratory Result Saliva saliva samples SARS‐CoV‐2 SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus Sex significant difference tested Treatment university virus was collected Yokohama [DOI] 10.1111/den.13945 PMC 바로가기 [Article Type] Original Article
A systematic review and meta-analysis protocol examining the clinical characteristics and epidemiological features of olfactory dysfunction (OD) in coronavirus disease 2019 (COVID-19)Protocol Published on 2021-03-112022-10-28 Journal: Systematic Reviews [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis Anosmia article caused China Chinese CINAHL Clinical characteristics Clinical data clinical evidence Clinical outcome clinical presentation CNKI Comprehensive conducted coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 patients database demographics described disease dysfunction epidemiological exclusion criteria feature human population identify IMPROVE include Inclusion Infrastructure item knowledge Meta-analysis olfactory olfactory dysfunction outbreak outcome pandemic Patient peer-reviewed performed plethora Prospective protocol Registered Reporting Research Research protocol review robust SARS-CoV-2 screened screening process searched Smell loss statistical analysis supplementary material systematic review VIP [DOI] 10.1186/s13643-021-01624-6 PMC 바로가기 [Article Type] Protocol
Proximal deep vein thrombosis and pulmonary embolism in COVID-19 patients: a systematic review and meta-analysisResearch Published on 2021-03-092022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] 95%CI absence Analysis anticoagulation appear article clinical trial clinically coronavirus COVID-19 Critically ill defined diagnosed DVT English Factors heterogeneous high risk ICU incidence Inpatient Inpatients lower limb Meta-analysis meta-analyze patients hospitalized Prospective protocol proximal regimen Registered Result review risk Screening secondary severity stratified subgroup supplementary material systematic review the disease Thromboprophylaxis thrombosis Thrombosis pulmonary embolism thrombotic risk Venous Thromboembolism VTE Web [DOI] 10.1186/s12959-021-00266-x PMC 바로가기 [Article Type] Research
Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET StudyProtocol Published on 2021-03-042022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] adaptive Analysis analyzed approved biochemical tests Biomarker Biomarkers blood sample Care clinical clinical information Coagulation Cohort collected Committee Complete consequence COVID-19 COVID-19 pandemic cytokine profile cytokine release deaths demographic characteristics design enrolled Ethics expected form Gene Expression genetics Health Hemostasis Human human host Identifier immune immune system immune systems Immunoglobulin immunology Inclusion Inflammation information knowledge leukocyte metabolomics Migration Mild Neutralizing antibodies Neutrophil extracellular trap neutrophil function objective parameter Patient patients with COVID-19 phagocytosis polymerase chain Prognosis Prospective proteomics reactive oxygen recruitment Registration registry report Result reverse transcription robust severe patients target the SARS-CoV-2 virus Thromboelastometry virus [DOI] 10.2196/24211 PMC 바로가기 [Article Type] Protocol