Blockade of SARS-CoV-2 spike protein-mediated cell–cell fusion using COVID-19 convalescent plasma코로나19 회복기 혈장을 이용한 SARS-CoV-2 스파이크 단백질 매개 세포-세포 융합 차단Article Published on 2021-03-102022-09-01 Journal: Scientific Reports [Category] SARS, 변종, 임상, 진단, 치료기술, [키워드] blocking activity convalescent plasma COVID-19 COVID-19 convalescent plasma COVID-19 pandemic cross-neutralize effector cell effector cells Emerging infectious disease examined exhibit global public health immunology Infectious disease inhibit interactions involved membrane fusion Microbiology molecular mechanism molecular mechanisms neutralizing antibody S protein SARS-CoV infections SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2-S target cells the SARS-CoV-2 therapeutic therapeutic agent titers of IgG to define virus virus entry [DOI] 10.1038/s41598-021-84840-3 PMC 바로가기 [Article Type] Article
Modelling the association between COVID-19 transmissibility and D614G substitution in SARS-CoV-2 spike protein: using the surveillance data in California as an exampleSARS-CoV-2 스파이크 단백질에서 COVID-19 전염성과 D614G 치환 간의 연관성 모델링: 캘리포니아의 감시 데이터를 예로 사용Research Published on 2021-03-092022-09-10 Journal: Theoretical Biology & Medical Modelling [Category] 유전자 메커니즘, [키워드] 95% CI adopted Amino acid amino acid substitution amino acid substitutions approach association codon COVID-19 COVID-19 pandemic D614G substitution demonstration disease disease control Evidence example explain Frequency Future global health glycine Health increase in instantaneous Measures mechanism Mutation pathogenic mutation pathogenic mutations Pathogens positive Prevalence quantified Reproduction number Result SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 spike SARS-CoV-2 spike protein sequence Spike protein statistical framework Statistical modeling Substitution supplementary material surveillance data the SARS-CoV-2 Transmissibility Transmission Variation [DOI] 10.1186/s12976-021-00140-3 PMC 바로가기 [Article Type] Research
Comparative sequence analysis of SARS-CoV-2 suggests its high transmissibility and pathogenicityResearch Article Published on 2021-03-082022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] adaptive Analysis analyzed bat-SL-CoV Comparative CoV COVID-19 Deletion disease severity Evolution feature furin-like cleavage site Genome highly pathogenic humans introduced material Multiple sequence alignment Mutation ORF1a/b ORF3a ORF3b ORF8 Pathogenesis pathogenicity Protein protein sequence Proteins SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike Sequence analysis Spike protein Transmissibility unique [DOI] 10.2217/fvl-2020-0204 PMC 바로가기 [Article Type] Research Article
The effect of spike mutations on SARS-CoV-2 neutralizationSARS-CoV-2 중화에 대한 스파이크 돌연변이의 영향Report Published on 2021-03-062022-09-11 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] Abstract active against acute respiratory syndrome acute respiratory syndrome coronavirus Alter Amino acid amino acid changes amino acid substitution amino acids antibodies antibody Antibody Response Antibody responses B.1.1.7 B.1.1.7 variant B.1.351 change changes in collected convalescent sera coronavirus Critical decrease Divergence effective Efficacy ENCODE evaluate highlight Immune escape individual Infection less lineages mild illness monoclonal antibody Multiple mutants mutated Mutation mutations neutralization Neutralizing antibodies neutralizing antibody new SARS-CoV-2 P.1 polyclonal antibodies polyclonal antibody potency produced Protective Protein pseudotype Pseudotyped virus Real-time monitoring recognizing reduced respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 pseudotyped virus SARS-CoV-2 spike SARS-CoV-2 variants SARS-CoV-2 virus sensitivity sera serology serum sample serum samples severe acute respiratory syndrome Coronavirus spike mutation Substitution Vaccine vaccine efficacy variant variant spike Variation Viral viral entry [DOI] 10.1016/j.celrep.2021.108890 PMC 바로가기 [Article Type] Report
Longitudinal antibody repertoire in “mild” versus “severe” COVID-19 patients reveals immune markers associated with disease severity and resolutionComparative Study Published on 2021-03-052022-10-04 Journal: Science Advances [Category] SARS, 바이오마커, 진단, [키워드] acute COVID-19 Affinity maturation antibody affinity Antibody binding antibody marker antibody repertoire antigenic clinical disease coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated disease severity effective epitope Evolution of SARS-CoV-2 faster fusion peptide IgA IgG immune marker immunodominant Immunoglobulin increase in knowledge Limited longitudinal maturation Mild Patient patients with COVID-19 prefusion RBD Receptor binding domain reveal SARS-COV-2 infection SARS-CoV-2 spike sequence severe COVID-19 [DOI] 10.1126/sciadv.abf2467 PMC 바로가기 [Article Type] Comparative Study
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity순환하는 SARS-CoV-2 스파이크 N439K 변이체는 항체 매개 면역을 피하면서 체력을 유지합니다Article Published on 2021-03-042022-09-11 Journal: Cell [Category] Fulltext, SARS, 변종, 진단, [키워드] antibody Antibody therapeutics binding affinity Clinical outcome consequence COVID-19 disease drug Efficacy Emergency use epidemiological evade FDA fitness food hACE2 hACE2 receptor highlighting Immunity immunodominant increase Infection Lineage mAb mAbs maintain molecular monoclonal antibody escape mutate Mutation N439K neutralizing monoclonal antibodies neutralizing monoclonal antibody polyclonal polyclonal antibody polyclonal sera prevalent protein structure RBM receptor binding motif receptor-binding motif reduce reducing Replication response responses S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike spike Surveillance the SARS-CoV-2 Therapeutics US Food and Drug Administration Usage Vaccine variable region variant Viral viral fitness virulence virus viruses wild type wild-type [DOI] 10.1016/j.cell.2021.01.037 PMC 바로가기 [Article Type] Article
A novel highly quantitative and reproducible assay for the detection of anti-SARS-CoV-2 IgG and IgM antibodiesArticle Published on 2021-03-042022-10-04 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] Accuracy acute respiratory syndrome Admission Analytical biochemistry anti-SARS-CoV-2 IgG antibody chemiluminescence clinical collected convalescent Coronavirus-2 detect detection diagnostic Effectiveness enzyme evaluated help IgG IgG and IgM IgM IgM antibody immunoassay Immunological techniques Infectious-disease diagnostics MERS-S negative sample not correlated Nucleocapsid proteins platform profile Proteins quantification Quantitative quantitative range reproducibility SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2-infected patient SARS-CoV-2-infected patients SARS1 serological test serum sample severity Spike protein [DOI] 10.1038/s41598-021-84387-3 PMC 바로가기 [Article Type] Article
Aptamer Conjugated Gold Nanostar-Based Distance-Dependent Nanoparticle Surface Energy Transfer Spectroscopy for Ultrasensitive Detection and Inactivation of Corona Virus코로나 바이러스의 초고감도 검출 및 비활성화를 위한 앱타머 접합 금 나노스타 기반 거리 의존 나노입자 표면 에너지 전달 분광법Article Published on 2021-03-042022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 치료기술, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen aptamer baculovirus binding Conjugated Corona Coronavirus infection demonstrated detection Diagnosis DNA energy energy transfer GNS gold limit of detection membrane nanoparticle outbreak persist Protein Protein binding pseudotyped Receptor binding recombinant antigen rhodamine SARS-CoV-2 spike SARS-CoV-2 spike protein Spectroscopy Spike protein surface virus virus infection [DOI] 10.1021/acs.jpclett.0c03570 PMC 바로가기 [Article Type] Article
Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasmaCOVID-19 혈장에서 SARS-CoV-2에 대한 항체 의존성 세포 세포 독성(ADCC)의 존재Research Article Published on 2021-03-042022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 진단, 치료기술, [키워드] ADCC ADCC activity addition antibody antibody-dependent cellular cytotoxicity calcein collected COVID-19 COVID-19 vaccine trials demonstrated detect Effector mechanism effector mechanisms focus high potency IgG antibodies immune responses immunofluorescence assay include individual magnitude NAb nAb response neutralization Neutralizing Neutralizing-antibody plasma plasma samples plasmas Presence Pseudotyped virus Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein specific IgG antibodies specific IgG antibody spike glycoprotein sub-Saharan Africa subject uninfected control Vaccine was used [DOI] 10.1371/journal.pone.0247640 PMC 바로가기 [Article Type] Research Article
Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse ModelResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Adenovirus Antigen attribute binding cleavage site Combination coronavirus COVID-19 deleted exchange expresse host cell human Angiotensin-converting enzyme include induce membrane fusion Middle East Model mouse Mutation Neutralizing antibodies polybasic proline proline mutations protective effect protective immunity Protein recombinant removal respiratory syndrome coronavirus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike shown Site spike Spike protein Spike proteins tested trimer Vaccine vaccine candidate Vaccine development while wild-type [DOI] 10.1128/mBio.02648-20 PMC 바로가기 [Article Type] Research Article