Isolation and Genomic Characterization of SARS-CoV-2 Omicron Variant Obtained from Human Clinical Specimens인간 임상 표본에서 얻은 SARS-CoV-2 오미크론 변이체의 분리 및 게놈 특성화Article Published on 2022-02-242022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] absence Analysis approach B.1.1.529 Cell Cell culture cell suspension changes in characterization clinical collected Contact COVID-19 cases Cytopathic effect demonstrated E gene failure followed by furin furin cleavage site Genome genome analysis hamster hamsters high viral load Host Human in vitro in vivo India infected cell infected cells initial inoculated International Isolation lung Mumbai Mutation nasal nasal turbinate Next-generation sequencing nucleotide omicron Omicron variant passage passages pathogenicity positive Replication SARS-CoV-2 sequence sequenced specimen specimens spike gene subsequent Syrian hamster tyrosine variant Vero CCL-81 Vero CCL-81 cell Vero CCL-81 cells Viral load virus virus isolate virus isolation [DOI] 10.3390/v14030461 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 infection in the general population by three prevailing rapid antigen tests: cross-sectional diagnostic accuracy study3 개의 우세한 빠른 항원 검사에 의한 일반 인구에서 SARS-COV-2 감염의 검출 : 단면 진단 정확도 연구Research Article Published on 2022-02-242022-09-01 Journal: BMC Medicine [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, 치료기술, [키워드] 95% CI Abbott Above Accuracy Ag-RDT Ag-RDTs analysed analyses Antigen Asymptomatic Becton Dickinson changes in COVID-19 COVID-19 test COVID-19 vaccination cross-sectional cross-sectional study cut-off detection develop diagnostic Diagnostic accuracy diagnostic test diagnostic tests E-gene enrolled evaluated false false-negative Ag-RDT Follow-up General population indication individual initial interquartile range invasive less log molecular nasopharyngeal nine PanBio participant point-of-care test point-of-care tests positive presenting Prevalence public health public health service Rapid Rapid antigen tests RDTs reduce reference test Result returned Roche Diagnostics sampling SARS-CoV-2 SARS-CoV-2 epidemiology SARS-COV-2 infection SARS-CoV-2 testing sensitivities sensitivity Specificities subsequent supplementary material Swab Symptom symptomatic System tested threshold Viral Viral load were assessed [DOI] 10.1186/s12916-022-02300-9 PMC 바로가기 [Article Type] Research Article
Effectiveness of face masks in blocking the transmission of SARS-CoV-2: A preliminary evaluation of masks used by SARS-CoV-2-infected individualsSARS-COV-2의 전송을 차단하는 데 얼굴 마스크의 효과 : SARS-COV-2에 감염된 개인이 사용하는 마스크의 예비 평가Research Article Published on 2022-02-232022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplified blocking caused Chain Reaction coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effectiveness Efficacy evaluate evaluated Face mask Face masks individuals infected individuals majority Mask Masks Median viral load men and women Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nasopharyngeal swabs no significant difference non-infected pandemic patients polymerase chain polymerase chain reaction Prevent Quantitative respiratory RNA SARS-CoV-2 SARS-CoV-2-infected individual SARS-CoV-2-infected individuals statistically significant difference Swab swabs symptomatic and asymptomatic symptomatic and asymptomatic patients Transmission transmission of SARS-CoV-2 transmitted Viral Viral load viral RNAs virus transmission [DOI] 10.1371/journal.pone.0264389 PMC 바로가기 [Article Type] Research Article
Dynamic Changes of the Blood Chemistry in Syrian Hamsters Post-Acute COVID-19급성 COVID-19 이후 시리아 햄스터의 혈액 화학의 동적 변화Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus albumin albumin level albumin levels Blood blood biochemistry blood chemistry blood sample Blood samples cause change changes in Chemistry Clinicians collected consequence coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 determine dynamic Effect hamster hamsters Health Histopathology histopathology of the lungs infected with SARS-CoV-2 Infection information inoculated long-term change long-term changes low-density Low-density lipoprotein lung lung damage Lung pathology Lungs Manifestations Mesocricetus moderate moderate to severe multiorgan disease Multiple Novel coronavirus observé pathology Patient Post-infection Potential treatment potential treatments processed Protein provide reported researcher respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe inflammation significantly syndrome total protein Triglyceride uric acid Viral Viral load virus weight loss [DOI] 10.1128/spectrum.02362-21 PMC 바로가기 [Article Type] Research Article
Discovery of SARS-CoV-2 3CL Pro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand InteractionsArticle Published on 2022-02-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), SARS, [키워드] 3CL accumulating acute respiratory syndrome anti-SARS-CoV-2 Antiviral assays binding energy breakthrough infections catalytic dyad cellular conserved coronavirus coronavirus disease covalent inhibitor drug candidate drug design dyad Efficacy effort etiological agent examined exhibited FIVE High-resolution histidine inhibitor inhibitors inhibitory Medicines molecular dynamics simulations molecule design Pro protease residue SARS-CoV-2 significantly structures Vaccine development Viral load viral replications [DOI] 10.3390/ijms23042392 PMC 바로가기 [Article Type] Article
Severe Thrombocytopenia as a Manifestation of COVID-19 InfectionReview Published on 2022-02-182022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory distress Asymptomatic bleeding change clinical manifestation Comorbidities Comorbidity Corticosteroid COVID-19 COVID-19 infection Deterioration diagnose disease Disseminated intravascular coagulation failure hematological High dose host immunity immune response Immune thrombocytopenia immunosuppressive Infection manifestation Obstructive Patient patients with COVID-19 Pneumonia risk severe complications severe thrombocytopenia severity thrombocytopenia thrombotic disorder Viral load virus [DOI] 10.3390/jcm11041088 PMC 바로가기 [Article Type] Review
Epidemiology of first cases of SARS-CoV-2 infection, from March to April 2020, in GabonArticle Published on 2022-02-172023-07-10 Journal: F1000Research [Category] COVID19(2023년), [키워드] COVID-19 diagnostic Epidemiology Gabon S gene Viral load [DOI] 10.12688/f1000research.74378.2 PMC 바로가기
A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection새로운 글루코코르티코이드 및 안드로겐 수용체 조절제는 SARS-CoV-2 감염의 시리아 햄스터 모델에서 바이러스 진입 및 선천성 면역 염증 반응을 감소시킵니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] 2019-nCoV 2019-nCoV/USA-WA1/2020 ACE2 acting Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration amplify Analysis androgen Androgen receptor angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animal animals antagonist antagonists bind caused CD4 Cell clinical development Clinical studies clinical study coronavirus COVID-19 Critical days post-infection decrease Defense domain dose-dependent DPI Efficacy enzyme examined expression glucocorticoid Glucocorticoid receptor golden hamster hamster Host host defense humans IL-6 indicated infiltration Inflammation inflammatory lung injury Inflammatory response Innate innate immune Innate immunity intranasally lack lung Lung histopathology Lung injury lung tissue Macrophage macrophages mechanism mechanism of action Model modulator molecular docking studies Molecular docking study novel oral administration outcome patients Phylogenetic analysis positive Predictive Prevent progression protease Protein PT150 receptor receptors reduce regulated Replication replication of SARS-CoV-2 required Research respiratory response Result SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection sequence identity Serine serine 2 severe acute respiratory syndrome Coronavirus shown strain surface protein T-cell T-cells TCID the cell therapeutic therapeutic efficacy Therapeutics tissue damage tissue injury TMPRSS2 transcriptional repressor transcriptionally transmembrane Treatment USA-WA1/2020 variants variants of SARS-CoV-2 Viral viral entry Viral load virus were infected [DOI] 10.3389/fimmu.2022.811430 PMC 바로가기 [Article Type] Immunology
Electrochemical detection of ACE2 as a biomarker for diagnosis of COVID-19 and potential male infertilityCOVID-19 및 잠재적 남성 불임 진단을 위한 바이오마커로서의 ACE2의 전기화학적 검출Article Published on 2022-02-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, 치료제, [키워드] ACE2 angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Biomarker Blood can not capture Clinical practice complex Covalent biosensing COVID-19 diagnosis of COVID-19 electrochemical potential enzyme Host index infertility male male infertility outcomes peptide Protein Proteins reagents restrict risk SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection secreted serum Serum level serum proteins serum sample serum samples target treating COVID-19 Viral Viral host target. viral invasion Viral load [DOI] 10.1016/j.bios.2021.113788 PMC 바로가기 [Article Type] Article
Circulating Type I Interferon Levels in the Early Phase of COVID-19 Are Associated With the Development of Respiratory FailureObservational Study Published on 2022-02-142022-10-04 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] Analysis association Blood chemokine circulation collected correlated COVID-19 CXCL10 development early phase ELISA enrolled evaluate failure Hypoxemia hypoxemic IFN-I IFN-α IFN-β IFNs IL-6 interferon-alpha Interferon-beta interleukin-6 Invasion Level Ligand motif objective onset of symptoms Patient patients hospitalized patients with COVID-19 phase Pneumonia prospective observational study qPCR recruited respiratory Respiratory failure Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load serum Serum level significantly significantly higher specimen symptom onset systemic immune response Type type I interferon Viral load was determined were measured with COVID-19 [DOI] 10.3389/fimmu.2022.844304 PMC 바로가기 [Article Type] Observational Study