FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination
Research
[키워드] Affect
Anti-viral immune response
approved
CD4+
CD8+ T cell
Central nervous system
clinical disease
CNS
correlated
cytokine production
cytolytic
Demyelination
disease
disease severity
disease-causing
dose
drug
Effect
effective
examined
exhibited
expression
flow cytometry
food
FTY720
IFN-γ
infiltration
Inflammatory
inhibiting
Lymph node
lymphocyte
mice
Migration
modulate
morbidity and mortality
Mortality
mouse hepatitis virus
multiple sclerosis
Neuroinflammation
neurologic
neurotropic
not affect
occur
Patient
Post-infection
proliferation
recorded
reduce
reduction in
Result
S1P receptor
severity
staining
T lymphocyte
T lymphocytes
Therapeutic benefit
TNF-α
treated
Treatment
viral replication
viral-induced
virus
virus-specific T cell
was determined
were infected
[DOI] 10.1186/s12974-014-0138-y PMC 바로가기 [Article Type] Research
[DOI] 10.1186/s12974-014-0138-y PMC 바로가기 [Article Type] Research