Epidemiologic and virologic assessment of the 2009 influenza A (H1N1) pandemic on selected temperate countries in the Southern Hemisphere: Argentina, Australia, Chile, New Zealand and South AfricaArticle Published on 2011-04-202023-06-23 Journal: Influenza and Other Respiratory Viruses [Category] 신종인플루엔자, [키워드] H1N1 influenza circulation pandemic severity southern hemisphere Transmission [DOI] 10.1111/j.1750-2659.2011.00249.x PMC 바로가기
CXCR2 Signaling Protects Oligodendrocytes and Restricts Demyelination in a Mouse Model of Viral-Induced DemyelinationResearch Article Published on 2010-06-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activating affected Apoptosis apoptotic cell BCL-2 binding caspase 3 Cell chemokine chronic infection cleavage cleaved clinical recovery CNS Culture CXCL1 CXCL2 CXCR2 decrease Demyelination disease elevated expression finding functional highlight increase in independent Infected Infection Inflammatory initiated inoculation Ligand Lineage mice Model modulation mouse mouse hepatitis virus Multiple Neuroinflammation neutralization neutralizing antiserum Oligodendrocyte pathology receptor sclerosis severity Signaling significantly susceptible sustained transcript viral infection [DOI] 10.1371/journal.pone.0011340 PMC 바로가기 [Article Type] Research Article
Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human PrimatesResearch Article Published on 2010-02-052022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome advanced age age analyses Analysis anti-inflammatory action ARDS Author cause Comprehensive contributed coronavirus correlated develop different differential expression diminishe disease displaying exacerbated expression Gene genomic H5N1 host response IFN-β IL-8 in viral increase in individual individuals Infection Inflammation influenza A Innate Intervention life-threatening Lungs macaque macaques Microarray modulation molecular mRNA level NF-κB outcome pandemic pathogen Pathogenesis pathology Pathways Patient primate pro-inflammatory gene expression Protective provide reduce reduced Replication response reveal SARS-CoV SARS-CoV infection severe severe pathology severity shown significantly significantly more syndrome Treatment type I Type I IFN type I interferon viral infection viral replication viral respiratory virus infection virus replication without affecting [DOI] 10.1371/journal.ppat.1000756 PMC 바로가기 [Article Type] Research Article
Avian coronavirus infectious bronchitis virus susceptibility to botanical oleoresins and essential oils in vitro and in vivoArticle Published on 2010-01-212022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] addition Administering Botanical extracts Clinical sign Compound coronavirus CPE, cytopathic effects Dilution disease effective EID50, 50% embryo infectious dose ELISA, enzyme linked immunosorbent assay essential oils examined expected greater HMA, hexamethylene amiloride Host IBV IBV, infectious bronchitis virus in vitro in vivo Infection Infectious Bronchitis Virus investigated knowledge Laboratory lesion Massachusett MHV, mouse hepatitis virus Natural ingredients Oleoresins PBS, phosphate buffered saline protection reduced RFLP, restriction fragment length polymorphism RT-PCR, Reverse transcriptase-polymerase chain reaction SARS-CoV, Severe Acute Respiratory Syndrome virus serotype severity SPF, specific pathogen free susceptibility TCID50, 50% tissue culture infectious dose Transmission Treatment Vero E6 cell Viral RNA virucidal virus Virus challenge virus inactivation virus titer viruses was determined [DOI] 10.1016/j.virusres.2010.01.006 PMC 바로가기 [Article Type] Article
RNase L Mediated Protection from Virus Induced DemyelinationResearch Article Published on 2009-10-022022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence Affect alteration ameliorated Anti-viral antiviral activity antiviral molecules Apoptosis apoptotic cell apoptotic cells Author Brain Cell Central nervous system characterized CNS coronavirus Coronavirus infection Critical deficiency Degradation Demyelination dependent on early Encephalitis Evidence expression foci function Host IFN-α/β immune in viral Increased induced induction of apoptosis Infected Infection Infectious virus infiltrating inhibiting Intervention majority manifested mechanism Mediated mice microglia mitigate morbidity morbidity and mortality mouse hepatitis virus neurodegeneration neuronal infection neurotropic not affect pathology pathway phenotype prevented proinflammatory PROTECT protection protective role recent reduce reflected RL RNA RNA degradation RNase severity Spread sustained tissue tissue damage translation type I interferon unique variant viral control viral replication viral spread viral tropism virus without affecting [DOI] 10.1371/journal.ppat.1000602 PMC 바로가기 [Article Type] Research Article
Novel Biomarkers for the Diagnosis of Urinary Tract Infection—A Systematic Review요로 감염 진단을 위한 새로운 바이오마커 - 체계적인 검토Review Published on 2009-08-052022-08-08 Journal: Biomarker Insights [Category] Biochemistry, [키워드] age asymptomatic bacteriuria Atypical bacteriuria Biomarker Clinical management conducted criteria database diabetics diagnose Diagnosis Diagnostic accuracy Diagnostic Criteria evaluated extreme immunocompromised individuals IMPROVE individual Infection interleukin interleukin 6 kidney transplant recipients methodology morbidity novel novel biomarkers paucity of data pediatric Population Prevalence procalcitonin procalcitonin level pyelonephritis Reporting review searched serum severity shown spinal cord Spinal cord injury STARD subgroup tract Treatment Urinalysis urinary urinary tract infection urinary tract infections urine culture UTI PMC 바로가기 [Article Type] Review
Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cellsResearch Article Published on 2009-06-082022-10-27 Journal: BMC Immunology [Category] Coronavirus, [키워드] 2003 Apoptosis biological significance Blood CCR chemokine Chemokine receptor compared DC DCs death dendritic cell explain expression Fa facilitate Gene Gene Expression Immune escape induce Infected Infection involved Ligand lung infiltration lymph nodes lymphocyte lymphoid mechanism Migration modulate monocyte outbreak provide receptor reported response Result SARS Coronavirus SARS patients SARS-CoV severity significantly TLRs Toll-like receptor Toll-like receptors TRAIL unique upregulation virus [DOI] 10.1186/1471-2172-10-35 PMC 바로가기 [Article Type] Research Article
Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cellsResearch Article Published on 2009-06-082022-10-28 Journal: BMC Immunology [Category] Coronavirus, Fulltext, MERS, [키워드] 2003 Apoptosis biological significance Blood CCR chemokine Chemokine receptor compared DC DCs death dendritic cell explain expression Fa facilitate Gene Gene Expression Immune escape induce Infected Infection involved Ligand lung infiltration lymph nodes lymphocyte lymphoid mechanism Migration modulate monocyte outbreak provide receptor reported response Result SARS Coronavirus SARS patients SARS-CoV severity significantly TLRs Toll-like receptor Toll-like receptors TRAIL unique upregulation virus [DOI] 10.1186/1471-2172-10-35 PMC 바로가기 [Article Type] Research Article
Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)Research Article Published on 2005-09-212022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome approach Asia biological systems Blood caused change changes in Clinical severity Clustering Control controls coronavirus correlated disease distress Epidemic expression profile Gene Gene Expression Genes Host human disease immunopathological damage Innate immunity International involved mortality rate Novel coronavirus pathophysiology Patient Peripheral blood Pulmonary infection recovering patient regulated reported Result SARS patient SARS patients SARS-CoV several gene severe severity significantly Spread upregulated while World Health Organization [DOI] 10.1186/1471-2164-6-132 PMC 바로가기 [Article Type] Research Article
Development of a homogeneous screening assay for automated detection of antiviral agents active against severe acute respiratory syndrome-associated coronavirusArticle Published on 2005-06-142022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] 2003 active against Antiviral antiviral activity antiviral agent Antiviral compounds antiviral drug antiviral potency assay automated be applied compounds coronavirus cytotoxicity demonstrated detect development Drug discovery EGFP expression evaluated Express facilitate fluorescent gastroenteritis Health High-throughput screening homogeneous inhibitor initial screening outbreak Protein risk SARS-CoV SARS-CoV infection severity specificity Spread therapeutic agent viral disease virus viruses [DOI] 10.1016/j.jviromet.2005.05.010 PMC 바로가기 [Article Type] Article