Antibody-based therapies for COVID-19: Can Europe move faster?Perspective Published on 2020-05-052022-10-29 Journal: PLoS Medicine [Category] COVID-19, MERS, SARS, [키워드] approach Can coronavirus effort Europe European Scientific community therapy [DOI] 10.1371/journal.pmed.1003127 PMC 바로가기 [Article Type] Perspective
Mesenchymal stem cells as a potential therapy for COVID-19Commentary Published on 2020-05-042022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, MERS, [키워드] 2019 novel coronavirus ALI ARDS cause cellular characterized clinical trial COVID-19 Critical disease distress effective hyaline membrane formation Inflammatory response lung mesenchymal stem cell MSC MSCs outbreak pathologic feature potential therapy presenting Pulmonary edema pulmonary inflammation raise Severe case specific treatment syndrome therapy Treatment [DOI] 10.1186/s13287-020-01678-8 PMC 바로가기 [Article Type] Commentary
Efficacy and safety of lower dose tenofovir disoproxil fumarate and efavirenz versus standard dose in HIV-infected, antiretroviral-naive adults: a multicentre, randomized, noninferiority trialHIV 감염, 항레트로바이러스 경험이 없는 성인에서 표준 용량 대비 저용량 테노포비르 디소프록실 푸마르산염 및 에파비렌즈의 효능 및 안전성: 다기관, 무작위, 비열등성 시험Article Published on 2020-05-042022-09-06 Journal: Emerging Microbes & Infections [Category] Communicable Disease, [키워드] 95% CI adverse event adverse events antiretroviral ARV assigned change comparable dose drug efavirenz Efficacy evaluate filtration rate fumarate glomerular filtration rate HIV HIV-1 HIV-1 infection infected patients initial intention-to-treat analysis lamivudine low dose lower dose lower toxicity multicentre non-inferiority non-inferiority margin non-inferiority trial occurred Open-label participant primary endpoint proportion Randomized Randomly receive receiving reduced regimen safety profile Standard dose Support tenofovir tenofovir disoproxil tenofovir disoproxil fumarate therapy Toxicity Treatment treatment difference Trial two groups [DOI] 10.1080/22221751.2020.1752609 PMC 바로가기 [Article Type] Article
Rheumotologitsts’ view on the use of hydroxychloroquine to treat COVID-19Letter Published on 2020-05-022022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome approved caused Chloroquine Chloroquine (CQ) clinical care clinical trial coronavirus COVID-19 COVID-19 patients disease effective Efficacy HCQ Hydroxychloroquine hydroxychloroquine (HCQ) immunomodulatory off-label pandemic coronavirus Rheumatic diseases SARS-CoV-2 Therapies therapy thought Topic treat Treatment use of hydroxychloroquine [DOI] 10.1080/22221751.2020.1760145 PMC 바로가기 [Article Type] Letter
COVID-19, asthma, and biological therapies: What we need to knowReview article Published on 2020-05-012022-10-05 Journal: The World Allergy Organization Journal [Category] 유전자 메커니즘, [키워드] and Blood Institute Asthma and Clinical Immunology Asthma and Immunology AAAAIAmerican Academy of Allergy absence ACAAIAmerican College of Allergy ACE2angiotensin-converting enzyme 2 ADCCAntibody-Dependent Cell-mediated Cytotoxicity administration adverse events AEsAdverse events Affect American Academy of Allergy American College of Allergy angiotensin-converting enzyme 2 antibody-dependent cell-mediated cytotoxicity Asthma authority British Thoracic Society BTSBritish Thoracic Society clinician coronavirus Coronavirus disease 2019 COVID-19 COVID-19 in patient COVID-19 pandemic COVID-19coronavirus disease 2019 Deoxyribonucleic acid DNADeoxyribonucleic acid EBMEvidence Based Medicine effective ELFEuropean Lung Foundation ERSEuropean Respiratory Society European Lung Foundation European Respiratory Society Evidence Based Medicine FDAFood and Drug Administration Food and Drug Administration GINAGlobal Initiative for Asthma Glaxo Smith Kline Global Initiative for Asthma GSKGlaxo Smith Kline help ICSinhaled corticosteroids ICUIntensive Care Unit IgEImmunoglobulin E IL13Interleukin 13 IL4Interleukin 4 IL5Interleukin 5 IL5RaInterleukin 5 alfa receptor IL5rInterleukin 5 receptor IL6Interleukin 6 Immunoglobulin E indicated inhaled corticosteroids intensive care unit Interleukin 13 Interleukin 4 Interleukin 5 Interleukin 5 alfa receptor Interleukin 5 receptor interleukin 6 Italian Society of Allergy lung mAbMonoclonal antibody maintain managing medication monoclonal antibody National Heart NHLBINational Heart OCSOral corticosteroids Oral corticosteroids pandemic Patient PDGFRAPlatelet-Derived Growth Factor Receptor A physician Platelet-Derived Growth Factor Receptor A Preventative Omalizumab or Step-up therapy for fall Exacerbations study PROSE studyPreventative Omalizumab or Step-up therapy for fall Exacerbations study question Randomized controlled trials RCTsrandomized controlled trials recommendation SAEsSerious Adverse Events SARPSevere Asthma Research Programme SARS-CoV-2 SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SCSubcutaneous Serious Adverse Events severe acute respiratory syndrome coronavirus 2 Severe Asthma Research Programme SIAAICItalian Society of Allergy Subcutaneous supported T2Type 2 inflammation the patient therapy TMPRSS2Transmembrane Protease Serine 2 Enzyme Transmembrane Protease Serine 2 Enzyme treated Type 2 inflammation underlying diseases United States of America USAUnited States of America [DOI] 10.1016/j.waojou.2020.100126 [Article Type] Review article
Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19Original Article Published on 2020-05-012022-11-01 Journal: The New England Journal of Medicine [Category] COVID-19, [키워드] 95% CI 95% confidence interval ACE ACE inhibitor Affect age Analysis ARB ARBs Asia association blocker Cardiac arrhythmia cardiovascular cardiovascular disease chair chronic obstructive concern Coronary artery disease Coronavirus disease 2019 database died discharge drug Europe evaluated Factor greater heart failure hospital hospitalized patient In-hospital death increased risk inhibitor Medicine Mortality North America observation Odds ratio Patient patients hospitalized pulmonary disease Result smoker smoking survived therapy were recorded William Harvey [DOI] 10.1056/NEJMoa2007621 PMC 바로가기 [Article Type] Original Article
Leptospirosis: a neglected tropical zoonotic infection of public health importance-an updated reviewReview Published on 2020-05-012023-06-22 Journal: European Journal of Clinical Microbiology & Infect [Category] 조류인플루엔자, [키워드] clinical manifestation laboratory diagnosis leptospirosis Prophylaxis therapy Treatment Weil’s disease. [DOI] 10.1007/s10096-019-03797-4 [Article Type] Review
COVID-19 Surface Persistence: A Recent Data Summary and Its Importance for Medical and Dental SettingsReview Published on 2020-04-302022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Characteristics concerning coronavirus coronavirus disease COVID-19 dental Diagnosis Epidemiology feature generate highlight Importance infection risk information pandemic persistence Psychological recent setting surface surfaces therapy virus [DOI] 10.3390/ijerph17093132 PMC 바로가기 [Article Type] Review
Current targeted therapeutics against COVID-19: Based on first-line experience in ChinaArticle Published on 2020-04-302023-07-01 Journal: Pharmacological research [Category] SARS, [키워드] Antiviral COVID-19 immunization therapy [DOI] 10.1016/j.phrs.2020.104854 PMC 바로가기 [Article Type] Article
Current evidence for directed and supportive investigational therapies against COVID-19Review Published on 2020-04-302022-10-28 Journal: African Journal of Thoracic and Critical Care Medicine [Category] COVID-19, [키워드] benefit Chloroquine clinical trials control group Coronavirus disease 2019 Corticosteroids Course COVID-19 current drug effective Evidence Favipiravir Health Hydroxychloroquine Interpretation Intervention Investigational directed therapies limitation Lopinavir/ritonavir patients peer-reviewed randomised controlled randomised controlled trial Registered Remdesivir Safe selected small sample size supportive therapy the disease Therapies therapy Tocilizumab Treatment Trial trials [DOI] 10.7196/AJTCCM.2020.v26i2.072 PMC 바로가기 [Article Type] Review