Balancing evidence and frontline experience in the early phases of the COVID-19 pandemic: current position of the Italian Society of Anti-infective Therapy (SITA) and the Italian Society of Pulmonology (SIP)Article Published on 2020-04-292022-11-01 Journal: Clinical microbiology and infection : the official [Category] COVID-19, SARS, [키워드] access acute respiratory syndrome Administered affected anti-inflammatory drug Antiviral approach balancing content coronavirus coronavirus disease COVID-19 COVID-19 patients Disease spectrum early phase enrolled Epidemic European Evidence IMPROVE intensive care Italian Italy management objective off-label Patient patients with COVID-19 physician Pneumonia provided Pulmonology randomized clinical trials Randomized controlled trial Region Respiratory failure SARS-CoV-2 secure selected Severe case Society Source Support supported supportive care symptomatic therapy Topic Treatment unlikely ventilator worsening [DOI] 10.1016/j.cmi.2020.04.031 PMC 바로가기 [Article Type] Article
Effectiveness of convalescent plasma therapy in severe COVID-19 patients중증 코로나19 환자에서 회복기 혈장 요법의 효과530 Published on 2020-04-282022-09-06 Journal: Proceedings of the National Academy of Sciences of [Category] Communicable Disease, COVID-19, SARS, [키워드] Absorption addition Antibody titers antiviral agent Antiviral agents approved C-reactive protein clinical benefit Clinical outcome clinical outcomes clinical symptom Clinical symptoms convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 criteria disappearance Donor dose Endpoint enrolled feasibility FIVE global health Health IMPROVE laboratory parameter Laboratory parameters lung lesion lung lesions lymphocyte Lymphocyte count maintain median time Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Novel coronavirus novel coronavirus disease optimal dose oxyhemoglobin oxyhemoglobin saturation parameter Patient pilot project primary endpoint Radiological examinations randomized trial Seven severe adverse effect severe COVID-19 severe COVID-19 patient Severe patient severe patients Significance significantly supportive care the patient therapy transfused transfusion Treatment Treatment outcome trials undetectable Viral Viral load Viral RNA Viremia [DOI] 10.1073/pnas.2004168117 PMC 바로가기 [Article Type] 530
Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients중국 우한에서 발생한 코로나바이러스감염증-19 감염의 성별 임상적 특징과 예후: 중증환자 168명을 대상으로 한 후향적 연구Research Article Published on 2020-04-282022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] 95% CI adjusted affected affecting age Analysis analyzed association best cellular response Cellular responses Characteristics clinical Clinical characteristics Clinical course clinician Comorbidities Comorbidity compared and analyzed conditions coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Critically ill diagnosed died discharged distribution epidemiological Evidence female patient Female patients females guide higher risk highlight Hospitalized Infection Laboratory laboratory parameter Laboratory parameters Logistic regression analysis male mechanism mediators men outcome pathogen pathway Patient patients positive correlation potential mechanism Prognosis progression provided Retrospective study risk Severe patient severe patients Sex Sex difference significant difference significant differences significantly susceptible therapy Tongji Hospital Treatment treatment of COVID-19 with COVID-19 women Wuhan Wuhan, China [DOI] 10.1371/journal.ppat.1008520 PMC 바로가기 [Article Type] Research Article
Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of WorkHypothesis Published on 2020-04-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ω-3 PUFAs acute respiratory syndrome adiponectin Care China city Cluster COVID-19 COVID-19 infection diet therapies dietary drug Evidence generate highlight hospital IL-6 IMPROVE Infection inhibitor intensive care unit Intervention lung infections mandatory measure Mild Modification mortality rate outcome outcomes pandemic patients Pneumonia positive patient Prevent pro-inflammatory cytokines regimen role Spread Taking the WHO therapy therapy for COVID-19 TNF-α WHO work World Health Organization Wuhan [DOI] 10.3390/ijms21093104 PMC 바로가기 [Article Type] Hypothesis
Addressing COVID‐19 Drug Development with Artificial IntelligenceEssay Published on 2020-04-272022-10-28 Journal: Advanced Intelligent Systems (Weinheim an Der Bergstrasse, Germany) [Category] COVID-19, [키워드] acute respiratory syndrome antibodies antibody approach approaches artificial artificial intelligence cause clinical trial Combination combination therapies combination therapy composed coronavirus COVID-19 COVID‐19 development drug drug combination Drug development Drug screening Efficacy effort ENhance evaluated Healthcare system identify Inc include Infectious disease intelligence Moderna Multiple outcomes pandemic pathogen Phase I regimen repurposed therapies SARS‐CoV‐2 severe acute respiratory syndrome coronavirus 2 sustained therapy timeline Treatment turn Vaccine Vaccine development Vaccines virus widespread [DOI] 10.1002/aisy.202000070 PMC 바로가기 [Article Type] Essay
A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology AnalysisPerspective Published on 2020-04-242022-10-30 Journal: Nutrients [Category] COVID-19, [키워드] acid acquisition acting activate applied approach biological processe Biology Combination conducted coronavirus CoV CoV infection Curcumin Cytokine storm dietary supplements excessive inflammatory response Genome glycyrrhizic acid Health immune immune response in vitro in vivo experiment Inflammation Inflammatory response Inflammatory responses inhibit inhibiting innate immune response interferon KEGG Kyoto MAPK signaling modulating network analysis NF-κB novel Ontology pathway pathway enrichment Pathways Prevent promote provide regulate Research response responses signaling pathway System System biology T-cells target therapy Vitamin Vitamin C [DOI] 10.3390/nu12041193 PMC 바로가기 [Article Type] Perspective
Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the LiteratureMedicine Published on 2020-04-242022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] administration of methylprednisolone ARDS association Chinese clinical outcomes conducted coronavirus Corticosteroid Corticosteroids COVID-19 database detrimental diagnosis of COVID-19 Effectiveness form forms glucocorticoid Health literature lower mortality Methylprednisolone nine outcomes participant patients with COVID-19 Pneumonia reduced reported review risk of death SARS-CoV-2 significantly Stage Support therapy use of corticosteroid [DOI] 10.3389/fmed.2020.00170 PMC 바로가기 [Article Type] Medicine
Translating IL-6 biology into effective treatments Reviews Published on 2020-04-232022-10-05 Journal: Nature reviews. Rheumatology [Category] SARS, 바이오마커, [키워드] anti-IL-6 receptor antibody production arteritis B cells condition COVID-19 Cytokine release syndrome disease Diseases dysregulation effective giant cell arteritis Health IL-6 IL-6 pathway immune regulation indications involved juvenile idiopathic arthritis pathway Pneumonia Research Rheumatic diseases rheumatoid arthritis secreted T cell targeting Therapeutic approach therapy Treatment [DOI] 10.1038/s41584-020-0419-z [Article Type] Reviews
Antiviral treatment of COVID-19Article Published on 2020-04-212022-10-29 Journal: Turkish Journal of Medical Sciences [Category] COVID-19, SARS, [키워드] Antiviral Chloroquine clinical trial Course courses COVID-19 COVID-19 patient effective antiviral treatment effective drugs Evidence Favipiravir human infections Hydroxychloroquine immunomodulating agent in vitro In-vitro Ivermectin life threatening Mild moderate observational studies Randomized controlled studies Remdesivir reported SARS-CoV-2 Stage supportive care therapy Treatment Trial Turkey [DOI] 10.3906/sag-2004-145 PMC 바로가기 [Article Type] Article
Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19Position article and Guidelines Published on 2020-04-202022-10-31 Journal: Military Medical Research [Category] COVID-19, Fulltext, SARS, [키워드] anticoagulation China Chinese Coagulation coagulation dysfunction Committee Consensus coronavirus disease COVID-19 COVID-19 patients death develop Diagnosis Epidemic include Medicine mortality rate outbreak Patient produced professional recommendation severe severe COVID-19 Severe COVID-19 Infection shown therapy Treatment Wuhan [DOI] 10.1186/s40779-020-00247-7 PMC 바로가기 [Article Type] Position article and Guidelines