Growth enhancement of porcine epidemic diarrhea virus (PEDV) in Vero E6 cells expressing PEDV nucleocapsid proteinResearch Article Published on 2019-03-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] accelerate affected assist Better Cell culture cell culture systems clone demonstrated diarrhea economic loss effective ENhance epidemic diarrhea expressing growth high mortality rate magnitude N expression Nidovirale nucleocapsid nucleocapsid protein outbreak Pathogens PEDV platform Protein Replication reproductive respiratory virus strain vaccine candidate Vaccine development vaccine production Vaccines Vero E6 cell VERO E6 cells virus virus production [DOI] 10.1371/journal.pone.0212632 PMC 바로가기 [Article Type] Research Article
A highly specific phage defense system is a conserved feature of the Vibrio cholerae mobilome매우 특이적인 파지 방어 시스템은 Vibrio cholerae mobilome의 보존된 특징입니다Research Article Published on 2017-06-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerate bacterial cell bacteriophage bacteriophages causative agent cell lysis cholerae chromosomal conserved contributed defend Defense diarrheal diarrheal disease disease cholera element Epidemic Evolution expansion favor feature FIVE Genetic genome replication genomic host cell host cells humans Infection investigated isolate killing Kinetics mechanism microbial community neighboring cell neighboring cells pathogen Patient phage phage genome phage-resistant phages predatory prevalent progeny Protective reduce respond selective spread to Stool strain unique Vibrio cholerae virulent widespread [DOI] 10.1371/journal.pgen.1006838 PMC 바로가기 [Article Type] Research Article
Porcine Epidemic Diarrhea Virus Induces Autophagy to Benefit Its ReplicationArticle Published on 2017-03-192022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] accelerate Analysis Apoptosis autophagy autophagy machinery benefit caused complex interplay confocal microscopy demonstrated effective epidemic diarrhea expression Infection Inflammatory cytokine Inflammatory responses NF-κB signaling Pathogenesis pathway PEDV PEDV replication positive feedback loop Replication reported Research RNA interference Therapeutic strategies transmission electron microscopy triggered virus virus infection [DOI] 10.3390/v9030053 PMC 바로가기 [Article Type] Article
Recombination Accelerates Adaptation on a Large-Scale Empirical Fitness Landscape in HIV-1재조합은 HIV-1의 대규모 경험적 피트니스 환경에 대한 적응을 가속화합니다Research Article Published on 2014-06-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerate adaptation data set dependent on Effect empirical evidence Evidence Evolution evolutionary dynamics examined facilitate fitness Genetic genetic diversity genetic material highlight HIV HIV-1 in vitro increase Increases increases in Interaction landscape mechanism Mutation mutation rate Mutation rates organism parameter Population Population size population sizes populations question raise Recombination recombination rate recombination rates sexual reproduction significantly Strains theory [DOI] 10.1371/journal.pgen.1004439 PMC 바로가기 [Article Type] Research Article
Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitisResearch Published on 2012-12-142022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] absence accelerate Activation Affect Analysis Anti-viral anti-viral activity Axonal damage bystander CD4 CD4 T cell CD4 T-cell CD4+ and CD8+ T cells CD8 CD8 T cell CD8 T-cell Central nervous system clinical disease CNS compared contribute coronavirus Cytometry decrease Encephalomyelitis ENhance enhanced evaluated Ex vivo expression Flow Gene expression analysis Gliatropic coronavirus help histocompatibility complex IFN-γ IL-21 impede increase Increased Infected Inflammation inhibitory inhibitory signal interactions interferon less Local Lymph node macrophages mice microglia MONITOR morbidity mRNA nitric oxide overcome pathology Population purified reduced regulated Result T helper T-cell T-cell Response target cells upregulation viral control was used were infected [DOI] 10.1186/1742-2094-9-269 PMC 바로가기 [Article Type] Research
Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory VirusesResearch Article Published on 2009-09-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accelerate accelerated antibody production Antigen appear Asymptomatic B cell CAGE cause CD4+ T cell clearance described destruction develop different disparate dose ENhance finding functional Host immune response immune response immune responses Immune-mediated Immunity independent Infection Inflammation influenza viruses inherent less limit lung lung damage Lymphoid tissue mechanisms morbidity nanoparticle novel virus pathogen Primary infection primary viral infection protection protective immune response Protein pulmonary viral recruitment Replication respiratory respiratory virus Safe SARS-coronavirus significant decrease significantly significantly increased specificity survival Treatment Vaccination strategies viral antigens viral clearance virus [DOI] 10.1371/journal.pone.0007142 PMC 바로가기 [Article Type] Research Article