epitope – Page 46 – Communicable Diseases Research

Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity

엘라스타제의 억제는 명반의 면역증강을 강화하고 항-SARS-CoV-2 전신 및 점막 면역을 촉진합니다.

423

Published on 2021-08-242022-09-12
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 진단,

Revelation of Potent Epitopes Present in Unannotated ORF Antigens of SARS-CoV-2 for Epitope-Based Polyvalent Vaccine Design Using Immunoinformatics Approach

면역정보학 접근법을 사용한 에피토프 기반 다가 백신 디자인을 위한 SARS-CoV-2의 주석이 없는 ORF 항원에 존재하는 강력한 에피토프의 계시

Immunology

Published on 2021-08-232022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 신약개발, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus allele Analysis antigen expression antigenic B-cell B-cell epitope B-cell epitopes canonical Canonical protein epitopes carried CD4+ T-cell CD8+ T-cell conformational coronavirus Coverage eight epitope epitope-based polyvalent vaccine Epitopes expressed FIVE followed by highest HLA I supergroups immunodominant immunogenic kill linear linear B-cell epitope linear B-cell epitopes linkers Mutation mutations N-protein Open reading frame open reading frames ORF ORF3c ORF7a Orf9b overlap Polyvalent potent present Protein Region regions respiratory revelation SARS-CoV-2 scenario severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein T-cell T-cell epitope T-cell epitopes the spike protein uORFs Vaccine variant variants
[DOI] 10.3389/fimmu.2021.692937 PMC 바로가기 [Article Type] Immunology

Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations

Research Article

Published on 2021-08-212022-10-31
Journal: Heliyon [Category] COVID-19,

[키워드] accompanied Analysis ancestor B-cell Bangladesh China Chittagong circulating clade Clinical data Complete country COVID-19 COVID-19 pandemic CpG D614G Deletion Diagnosis downloaded Epidemiology epitope European country evade event Evolution functional genetic diversity Genome genome sequence Genome sequencing genomic change GISAID GISAID database Host immune response implication include India insertions isolate isolates less Missense Missense mutation MOST Mutation mutations Nextstrain nucleotide occurred ORF7a ORF8 gene P323L Pathogenesis PCR Phylogeny predict predicted prevalent RdRP reduce reference sequence Region reported reveal RT-PCR SARS-CoV-2 SARS-CoV-2 genome selective sequence severity single nucleotide variations Spike protein submitted synonymous T-cell target region the disease the SARS-CoV-2 virus unique variant viral clearance viral replication virus Wuhan
[DOI] 10.1016/j.heliyon.2021.e07866 PMC 바로가기 [Article Type] Research Article

Analysis of the molecular mechanism of SARS-CoV-2 antibodies

SARS-CoV-2 항체의 분자 메커니즘 분석

Review

Published on 2021-08-202022-09-11
Journal: Biochemical and Biophysical Research Communication [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] antibody antibody cocktail beta-coronavirus binding domain binding epitope caused Chinese death effective epitope Epitopes human cells include infect Infection mechanism molecular mechanism monoclonal antibodies monoclonal antibody neutralize Neutralizing activity NTD pandemic provide RBD Receptor binding domain receptor binding domain (RBD) Region reported Research respiratory Respiratory disease S protein S proteins SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 mutants Spike proteins TCM the antibody the S protein the SARS-CoV-2 the spike protein therapy Traditional Chinese medicine Treatment treatment strategy Vaccine vaccine therapy WHO
[DOI] 10.1016/j.bbrc.2021.06.001 PMC 바로가기 [Article Type] Review

An immunoinformatics study: designing multivalent T-cell epitope vaccine against canine circovirus

Research

Published on 2021-08-182022-10-30
Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19,

[키워드] adjuvant Algorithm Amino acid ANN Antigen artificial canine Canine circovirus CAP cause conducted Dog leukocyte antigen epitope epitope vaccine Epitopes Escherichia coli expressed expression gastroenteritis Genome Hemorrhagic immune response immunoinformatics In silico cloning In silico methods in vitro in vivo experiments infections leukocyte linker molecular docking molecular dynamic simulations Molecular dynamics simulation Open reading frame opposite ORFs pathogen peptide-based vaccine performed Protein Result Screening selected selected epitope stability T-cell the vaccine Transcription vaccine construct Vaccine designing Vasculitis were used
[DOI] 10.1186/s43141-021-00220-4 PMC 바로가기 [Article Type] Research

Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

2회분의 SARS-CoV-2 백신 접종은 우려되는 새로운 SARS-CoV-2 변종에 대한 강력한 면역 반응을 유도합니다

Article

Published on 2021-08-172022-09-10
Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antimicrobial responses B.1.1.7 B.1.351 circulating Cohort conserved coronavirus dose epitope Epitopes generate high potency immune response immune responses immunization induce Infection Lineage magnitude majority natural infection neutralization Pathogens Pfizer Pfizer-BioNTech PROTECT prototype report required respiratory response robust SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 vaccination SARS-CoV-2 variant second dose second dose of vaccine severe acute respiratory syndrome Coronavirus single dose T cell T cell response T cells understanding vaccination Vaccine vaccine doses Vaccines variants variants of concern VoC
[DOI] 10.1038/s41467-021-25167-5 PMC 바로가기 [Article Type] Article

A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

SARS-CoV-2 변이체에 대한 광범위 중화 인간화 ACE2 표적 항체

Article

Published on 2021-08-172022-09-10
Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료제,

[키워드] ACE2 complexes acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered against SARS-CoV alleviate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme-2 antibody Antibody therapy blocking antibody blood pressure circulating complexes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 domain dosage effective therapy epitope event exhibit hACE2 hindrance humanized in vitro Infection inhibitory activity injection Injections Intervention Isolation limit Lineage lineages monoclonal antibody morbidity morbidity and mortality Neutralizing pandemic Prevent prophylactically RBD receptor Receptor-binding domain respiratory risk SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 replication SARS-CoV-2 variant SARS-related coronavirus SARS-related coronaviruses SARSr-CoVs significant changes in Spread Structure structures therapeutic Transmission variants
[DOI] 10.1038/s41467-021-25331-x PMC 바로가기 [Article Type] Article

Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients

SARS-CoV-2에 대한 체액성 면역의 동적 지형 매핑은 중요한 COVID-19 환자의 생존과 관련된 비구조적 단백질 항체를 식별합니다

Article

Published on 2021-08-172022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody Antibody Response Antibody responses binding epitope clinical variable clinical variables Cohort comprehensive analysis coronavirus correlation COVID-19 COVID-19 pathogenesis COVID-19 severity Critical critical COVID-19 patient diagnostics dynamic epitope Epitopes help high mortality high mortality rate humoral immune response Humoral immunity identify IgG antibodies IgG antibody IgM and IgG IgM antibodies IgM antibody immunogenic independent Infectious diseases innate immune response longitudinal analysis Microarray non-structural protein nonstructural protein nonstructural proteins Nsp3 Nsps nucleocapsid ORF3a Patient patients peptide peptide-based performed polyprotein Prognosis Proteases Protein respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 replication serum serum sample serum samples severe acute respiratory syndrome Coronavirus severity spike structural protein structural proteins survival therapy Transcription Treatment with COVID-19
[DOI] 10.1038/s41392-021-00718-w PMC 바로가기 [Article Type] Article

Humoral Responses to Single-Dose BNT162b2 mRNA Vaccination in Dialysis Patients Previously Infected With SARS-CoV-2

Medicine

Published on 2021-08-172022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Molecular docking and dynamic simulation of conserved B cell epitope of SARS-CoV-2 glycoprotein Indonesian isolates: an immunoinformatic approach

Research Article

Published on 2021-08-162022-10-31
Journal: F1000Research [Category] COVID-19, MERS, SARS,

[키워드] Activation acute respiratory syndrome addition Antigen antigenic approach B cell B cell epitope BCR binding Brazil calculated Candidates carried CD4+ cell China complex conserved conserved region. coronavirus country COVID-19 differentiation docking epitope gene sequence GISAID histocompatibility complex HLA Immunoinformatic India Indonesia Infectious disease investigated isolate isolates leukocyte lowest memory response MHC-II molecular NCBI non-toxic peptide predicted produced receptor Region SARS-CoV-2 SARS-CoV-2 glycoprotein SARS-CoV-2 isolate SARS-CoV-2 spike glycoprotein sequence South Africa spike glycoprotein T cell The United States the vaccine Toxicity United Kingdom Vaccine vaccine candidate Virus neutralization Wuhan
[DOI] 10.12688/f1000research.54258.1 PMC 바로가기 [Article Type] Research Article