Modelling the COVID-19 epidemic and implementation of population-wide interventions in Italy Research Published on 2020-04-222022-10-05 Journal: Nature Medicine [Category] SARS, 치료기술, 치료법, [키워드] confirmed case Contact tracing Course COVID-19 epidemic COVID-19 pandemic death diagnosed effective eight ending explain Fatality rate help implementation individual infected individual Infection Intervention Italy less measure positive predict Registered SARS-CoV-2 SARS-CoV-2 pandemic severity social distancing Spread Stage susceptible Symptoms tested the epidemic widespread [DOI] 10.1038/s41591-020-0883-7 [Article Type] Research
Novel Coronavirus: Current Understanding of Clinical Features, Diagnosis, Pathogenesis, and Treatment OptionsReview Published on 2020-04-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 2019-nCoV acute respiratory syndrome Affect antiviral drug caused clinical computed tomography scan consequence coronavirus coronavirus disease cough coughing COVID-19 current Diagnosis diagnostics diarrhoea effective Fever humans include individual infected individual molecular novel occur option Pathogenesis polymerase chain reduce reducing released respiratory complication SARS-CoV-2 SARS-CoV-2 infections secretion thought Transmission transmission of SARS-CoV-2 Treatment understanding Viral load vomiting [DOI] 10.3390/pathogens9040297 PMC 바로가기 [Article Type] Review
A mathematical model for simulating the phase-based transmissibility of a novel coronavirusResearch Article Published on 2020-02-282022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, SARS, [키워드] 2019-nCoV acute respiratory syndrome adopted approach basic reproduction number bats calculate Chinese Committee coronavirus develop etiology expected human infection infected individual Infection mathematical mathematical model MERS Middle East Next generation matrix Novel coronavirus Pneumonia potential transmission reported Result SARS-CoV-2 Seafood Secondary infection susceptible syndrome taxonomy the SARS-CoV-2 Transmissibility transmissibility of SARS-CoV-2 Transmission virus World Health Organization Wuhan [DOI] 10.1186/s40249-020-00640-3 PMC 바로가기 [Article Type] Research Article
Communicating the Risk of Death from Novel Coronavirus Disease (COVID-19)Editorial Published on 2020-02-212022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] actual risk addressed approach Asymptomatic Care Communicating Comorbidity COVID-19 COVID-19 epidemic cumulative dataset death defined diagnosed diagnostic laboratory tests disease Emerging infectious diseases epidemiological fatality General population Health authority illness onset individual infected individual less majority mild infection novel occur problems proportion reported risk risk of death Seasonal influenza second Severity of infection Statistical estimation virulence virus virus detection [DOI] 10.3390/jcm9020580 PMC 바로가기 [Article Type] Editorial
Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In VitroArticle Published on 2018-05-242022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] acute respiratory illness acute respiratory syndrome anticancer antiviral activity approved drug Arabian Peninsula cause clinically Combination composed compounds country current drug drug candidates early stage exhibited Fatality rate gemcitabine Huh-7 cells Human human infection in vitro infected individual inhibit inhibitor kinase MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome occurred outbreak pathogen Replication respiratory RNA viruses saracatinib Saudi Arabia screened signaling pathways South Korea spread to Src-family kinase inhibitor synergistic therapeutic option Treatment tyrosine viral life cycle zoonotic [DOI] 10.3390/v10060283 PMC 바로가기 [Article Type] Article
Deep sequencing of HBV pre-S region reveals high heterogeneity of HBV genotypes and associations of word pattern frequencies with HCCHBV pre-S 영역의 심층 시퀀싱은 HBV 유전자형의 높은 이질성과 HCC와 단어 패턴 빈도의 연관성을 보여줍니다Research Article Published on 2018-02-232022-09-06 Journal: PLoS Genetics [Category] B형 간염, Communicable Disease, [키워드] Accuracy Analysis approach approaches association AUC build calculated can be used characteristic CHB China Classifier Clustering Complication Cross-validation data set deep followed by fraction Frequency Genotype group HBV HBV infection HCC HCC patient hepatitis B Hepatitis B virus Hepatocellular carcinoma heterogeneity Hierarchical hierarchical clustering high accuracy High-throughput sequencing include independent data set individual individuals infected individual infected individuals Infection information lead liver Liver cancer Manhattan distance MDs next generation sequencing NGS predict prevalent Probability regions reveal Sanger sequencing second sequence sequences Sequencing shown significantly Support support vector machine SVM virus was obtained [DOI] 10.1371/journal.pgen.1007206 PMC 바로가기 [Article Type] Research Article
Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years updateResearch Article Published on 2017-10-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Arabian Peninsula Asia Bahrain continuum Corporation Council country death demographics distribution effective Europe female geographical region Gulf Health identify indicate infected individual Infection Kuwait laboratory-confirmed magnitude male MERS-CoV MERS-CoV infection Middle East North America Occurrence Oman outbreak physician potential risk Prevalence prevalent reported required respiratory respond Saudi Arabia Scientific community the disease United Arab Emirate were recorded WHO World Health Organization [DOI] 10.1371/journal.pone.0183850 PMC 바로가기 [Article Type] Research Article
Serological assays for emerging coronaviruses: Challenges and pitfallsArticle Published on 2014-03-232022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] acute respiratory syndrome addition Analysis antibody Antibody detection Antigen applicability applied challenge common cold conserved Contact coronavirus CoV CoV spike protein CoVs cross-reactive antibody cross-reactivity Diagnosis diagnostic diagnostics Epidemic epitope highlight IMPROVE improvement infected individual information Isolation less majority MERS MERS-coronavirus MERS-CoV Middle East multiple method Novel viruses Nucleic acid detection nucleocapsid protein Nucleocapsid proteins occur occurred Occurrence outbreak problem public health authorities reported researcher reservoir reservoirs SARS-coronavirus SARS-CoV Sensitivity and specificity sera serological Serological assay Serological testing serology Spike protein Spread subsequent syndrome tested variety viral antigens [DOI] 10.1016/j.virusres.2014.03.018 PMC 바로가기 [Article Type] Article
The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus PathogenesisReview Published on 2012-11-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Accessory accessory protein accessory proteins acute respiratory syndrome affected caused cellular China coronavirus country Effect eight ENCODE expression functional Genome homologous homologues human-to-human transmission infected individual infected individuals Infection Isolation knowledge membrane mortality rate Novel coronavirus nucleocapsid Open reading frame open reading frames ORFs predicted Protein Proteins reported Research respiratory Respiratory disease resulting role SARS-coronavirus SARS-CoV severe Spread subsequent unique virus [DOI] 10.3390/v4112902 PMC 바로가기 [Article Type] Review
Towards a Coronavirus-Based HIV Multigene VaccineResearch Article Published on 2006-01-012022-10-31 Journal: Clinical and Developmental Immunology [Category] Coronavirus, [키워드] Adults aminopeptidase N anti-HIV drug antigen presenting cell antigens cause CD13 children common cold coronavirus Coronavirus infection costly DC DCs dendritic cell Efficiency enteric diseases expressed feature Gene Gene Expression HCoV 229E Health Heterologous HIV Human human coronavirus 229E humans immunodeficiency virus infected individual infecting Infection Macrophage Molecular biology mucosal surfaces occur pre-existing immunity Prevent Re-infection receptor replaced required RNA second significantly Spread These cells threat transcriptional Transmission Treatment upper respiratory tract vaccination Vaccination strategy Vaccine Vaccines vector Virus-like particle VLPs [DOI] 10.1080/17402520600579168 PMC 바로가기 [Article Type] Research Article