Impact of COVID-19 Pandemic on Serum Vitamin D Level among Infants and Toddlers: An Interrupted Time Series Analysis and before-and-after ComparisonArticle Published on 2021-04-132022-10-30 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] age Analysis analyzed changes in coronavirus disease COVID-19 COVID-19 outbreak deficiency group guideline Hong Kong Impact implementation Infant Infants Interrupted Interrupted time series Level magnitude measure mother outbreak pandemic pregnant women random recommendation recruited reduction in Regression risk serum serum 25-hydroxyvitamin D Sery social distancing stratified subsequent sustained time Vitamin D was performed were used [DOI] 10.3390/nu13041270 PMC 바로가기 [Article Type] Article
Role of interferon therapy in severe COVID-19: the COVIFERON randomized controlled trial중증 COVID-19에서 인터페론 요법의 역할: COVIFERON 무작위 대조 시험Randomized Controlled Trial Published on 2021-04-132022-08-13 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 치료제, [키워드] 95% CI adverse events Arm assigned benefit Chest CT scans clinical Clinical improvement clinical seven-step ordinal scale ClinicalTrials.gov, NCT04343768 conducted control group Controlled trial CT scan defined discharge Effect Enrollment FIVE Hydroxychloroquine IFNs IFNα IFNβ IFNβ1a IFNβ1b improvement indicated individually-randomized injection intention-to-treat population interferon interferons intervention group laboratory-confirmed SARS-CoV-2 infection Lopinavir Lopinavir/ritonavir median Mortality NCT04343768 no significant difference no significant differences Open-label Ordinal Scale P-value Patient positive positive RT-PCR Previous studies previous study primary outcome measure randomization Randomized controlled trial Randomly reduction in Registration registration number Respiratory tract diseases Ritonavir role SARS-COV-2 infection Seven severely ill patient significant difference single dose subcutaneous injections therapeutic therapy time Trial Registration Number TTCI twice a day type 1 interferon type 1 interferons Viral viral infections [DOI] 10.1038/s41598-021-86859-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical TrialRandomized Controlled Trial Published on 2021-04-132022-10-05 Journal: JAMA [Category] SARS, 임상, [키워드] adverse event clinical clinical benefit clinically collected conducted Course COVID-19 database determine Effect enrolled follow-up period hazard ratio headache Health Hospitalized IMPROVE IQR Ivermectin ivermectin group laboratory-confirmed log-rank test median age median time Mild multiorgan failure outcome outcomes Patient per day Placebo Potential Potential treatment primary analysis population random Randomized randomized trial receive reported Resolution resolution of symptom resolution of symptoms resolved Serious Adverse Event significantly study participant study period Support Symptom symptomatic Symptoms the placebo group time Treatment Trial with mild disease women [DOI] 10.1001/jama.2021.3071 PMC 바로가기 [Article Type] Randomized Controlled Trial
Time Distributions of Common Respiratory Pathogens Under the Spread of SARS-CoV-2 Among Children in Xiamen, ChinaPediatrics Published on 2021-04-122022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] acute respiratory syndrome Adenovirus analyzed changes in children China Combination common coronavirus COVID-19 detection rate group implementation Influenza Influenza virus Intervention measure Measures observé parainfluenza virus pediatric pharyngeal positive predict prevention quarantine reduced reported respiratory Respiratory disease respiratory syncytial virus respiratory viral infection respiratory virus respiratory viruses retrospective RSV SARS-CoV-2 screened significantly statistically significant difference study population swabs tested the SARS-CoV-2 time Transmission viral respiratory infections was selected Xiamen [DOI] 10.3389/fped.2021.584874 PMC 바로가기 [Article Type] Pediatrics
Evolving Paradigm of Prothrombin Time Diagnostics with Its Growing Clinical Relevance towards Cardio-Compromised and COVID-19 Affected Population심장 기능 저하 및 COVID-19 영향을 받는 인구에 대한 임상 관련성이 증가하면서 프로트롬빈 시간 진단의 진화하는 패러다임Review Published on 2021-04-092022-09-10 Journal: Sensors (Basel, Switzerland) [Category] MERS, SARS, 치료기술, [키워드] Acoustics administration affected anticoagulation anticoagulation therapy assays Biomarker Blood blood clotting Blood coagulation candidate Candidates clinical Clotting time Coagulation Coagulopathy Complication correlation COVID COVID associated coagulopathy (CAC) COVID-19 Critical detect diagnose diagnostics Evolution fatality Hemorrhagic Hemostasis incidence international normalized ratio (INR) optics paradigm physiological platform point of care point of care (PoC) point-of-care Population Prolonged prothrombin Prothrombin time prothrombin time (PT) protocol recent Relevance Sepsis sepsis-induced coagulopathy therapy thromboembolic Thromboembolism time [DOI] 10.3390/s21082636 PMC 바로가기 [Article Type] Review
Continuous Spinal Anaesthesia for Intertrochanteric Femur Fracture in a Patient with Skeletal DysplasiaCase Report Published on 2021-04-092022-10-31 Journal: Case Reports in Anesthesiology [Category] COVID-19, [키워드] airway anaesthesia anticipated blockade carried clinical condition Continuous dose dysplasia Femur fixation Fracture hemodynamic stability Local male obesity offer Patient provide reduced short stature skeletal spinal surgical time turn [DOI] 10.1155/2021/6644894 PMC 바로가기 [Article Type] Case Report
Addressing the Digital Inverse Care Law in the Time of COVID-19: Potential for Digital Technology to Exacerbate or Mitigate Health InequalitiesViewpoint Published on 2021-04-072022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, MERS, SARS, [키워드] approach Care contributing to COVID-19 COVID-19 pandemic Deprivation Digital digital divide digital exclusion Digital health engage Factor Health Health inequality inequality information inverse law Older pandemic Population Population health populations Potential PROTECT Support sustained technology time [DOI] 10.2196/21726 PMC 바로가기 [Article Type] Viewpoint
Prioritizing Surgical Services during on-Going Pandemic Response: Modification and Reliability of the Medically Necessary Time Sensitive Surgery (MeNTS) Scoring ToolSystems-Level Quality Improvement Published on 2021-04-072022-10-29 Journal: Journal of medical systems [Category] Coronavirus, MERS, SARS, [키워드] Analysis approach assessments assumed cardiovascular disease Care center clinician Cohort COVID Critically ill patient Decision-tool demonstrated Department diabetes evaluated expand female Final healthcare Healthcare resources hospital Hospital administration ICC indication initial invasive iterative Los Angele Lung disease majority multicenter Normal distribution Olive operative organ over pandemic Patient Pelvic performed predominant Quantitative Range reliability Scoring sensitive service surgery surgical Surgical services the patient time university uterine bleeding vaginal surgery View Volume with COVID-19 [DOI] 10.1007/s10916-021-01731-w PMC 바로가기 [Article Type] Systems-Level Quality Improvement
Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and ImmunomodulationReview Published on 2021-04-062022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] adjuvant Antigen approach B cell responses choice Combination component Critical Delivery system design Diseases effective Efficacy Establishing facilitate generate immune immune correlate immune response immunization immunological immunomodulation imperative knowledge life-threatening medical intervention memory Mortality preventing infection protection protective immune response rational route T cell time Vaccine vaccine antigen Vaccines [DOI] 10.3390/pharmaceutics13040501 PMC 바로가기 [Article Type] Review
Comparative analysis of various clinical specimens in detection of SARS-CoV-2 using rRT-PCR in new and follow up cases of COVID-19 infection: Quest for the best choice코로나19 신규 및 후속 감염 사례에서 rRT-PCR을 이용한 SARS-CoV-2 검출 시 다양한 임상 검체의 비교 분석: 최선의 선택을 위한 탐구Research Article Published on 2021-04-052022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] affected Analysis average Chain Reaction Combined Comparative analysis COVID-19 COVID-19 treatment Ct values cycle threshold demographic Diagnosis diagnosis and monitoring diagnostic disease evaluate evaluated female Follow-up followed by help high viral load hour Implementing in urine indicate initial initiation of treatment lowest male management nasopharyngeal Nasopharyngeal swab nCoV Novel coronavirus NPs ORF1b oropharyngeal swab pandemic patients physician plasma polymerase chain reaction quest Randomly RdRP Result rRT-PCR SARS-CoV-2 selected serum specimen specimens sputum Swab symptomatic case time Treatment Urine utility Viral Viral load virus clearance [DOI] 10.1371/journal.pone.0249408 PMC 바로가기 [Article Type] Research Article