RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection
Research article
[키워드] Activation
agonist
Antiviral
antiviral immunity
antiviral response
Antiviral treatment
approach
Brain
coronavirus
COVID-19
disease severity
effective
emerging viruses
exhibited
innate antiviral immunity
innate immune
Innate immunity
K18-hACE2
K18-hACE2 mouse model
Ligand
lung
Lung inflammation
mice
MT: Oligonucleotides: Therapies and Applications
Neutralizing antibody response
nucleic acid immunity
oropharyngeal swab
outcome
pandemic
Prophylactic
PROTECT
receptor
reduce
reduced
RIG-I
RNA
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 pandemic
Spread
survival
therapeutic
therapy
Treatment
Type I IFN
type I interferon
Vaccine
viral challenge
Viral load
virus
viruses
[DOI] 10.1016/j.omtn.2022.02.008 [Article Type] Research article
[DOI] 10.1016/j.omtn.2022.02.008 [Article Type] Research article