Bone Metabolism in SARS-CoV-2 Disease: Possible Osteoimmunology and Gender ImplicationsReview Paper Published on 2020-09-012022-10-31 Journal: Clinical Reviews in Bone and Mineral Metabolism [Category] COVID-19, [키워드] adverse effect available data bone consequence COVID-19 COVID-19 disease COVID-19 patients deficiency Denosumab disease effective effort Fracture risk Gender IL-1 IL-6 immune system implication Infection inflammatory condition Inflammatory cytokines inflammatory disease marker metabolism molecular mechanism Osteoporosis outbreak Patient Prevent risk Safe SARS-CoV SARS-CoV-2 SARS-COV-2 infection stimulate subsequent survival targeting therapeutic strategy therapeutic target TNF-α Vitamin D [DOI] 10.1007/s12018-020-09274-3 PMC 바로가기 [Article Type] Review Paper
Health Anxiety and Mental Health Outcome During COVID-19 Lockdown in Italy: The Mediating and Moderating Roles of Psychological FlexibilityPsychology Published on 2020-08-312022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] adverse effect affected Anxiety Combination COVID-19 COVID-19 emergency decrease Depression detrimental distress Effect emotional examined female flexibility greater Health anxiety high risk Impact increase increases in indicated Intervention Italian Italian population lockdown mandatory measure Mediating Mental mental health moderate mood disturbance National outcomes pandemic Psychological psychological flexibility psychological health Public health intervention quarantine Research Resilience Result risk role therapy thought [DOI] 10.3389/fpsyg.2020.02195 PMC 바로가기 [Article Type] Psychology
The Importance of Redox Status in the Frame of Lifestyle Approaches and the Genetics of the Lung Innate Immune Molecules, SP-A1 and SP-A2, on Differential Outcomes of COVID-19 InfectionReview Published on 2020-08-252022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] activate Activation adverse effect Affect antioxidant antioxidants cellular chronic inflammation COVID-19 Defense disease symptom exercise expression fasting Free radicals genetics Host immune system Immunity Importance increased mortality Inflammation Innate innate immune Local lung Lung disease mechanism microenvironment molecules obesity occur oxidative oxidative damage oxidative stress pandemic of COVID-19 protein A redox reduce regimens SARS–CoV-2 Scientific community shown status surfactant protein A the disease underlying diseases weight loss [DOI] 10.3390/antiox9090784 PMC 바로가기 [Article Type] Review
Hydroxychloroquine in COVID-19: Potential Mechanism of Action Against SARS-CoV-2Covid-19 (ATY Lau and A Kong, Section Editors) Published on 2020-08-242022-11-01 Journal: Current Pharmacology Reports [Category] COVID-19, [키워드] ACE2 Action acute respiratory syndrome adverse effect Against angiotensin-converting enzyme 2 antiviral role binding site blockade Chloroquine clinical trial coronavirus coronavirus disease country COVID-19 COVID-19 patients Cytokine storm death demonstrated drug drugs Endocytic pathway evaluate finding gastrointestinal complications HCQ Hydroxychloroquine include mechanism of action mild infection multiple organ failure pandemic positive result Potential protein cleavage QT interval QT prolongation recent receptors Respiratory failure review SARS-CoV-2 shown sialic acid Side effects Spread therapeutic option Till treat treated upper respiratory tract viral infection Viral pneumonia virus [DOI] 10.1007/s40495-020-00231-8 PMC 바로가기 [Article Type] Covid-19 (ATY Lau and A Kong, Section Editors)
Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently NeededReview Published on 2020-08-242022-10-30 Journal: Nutrients [Category] COVID-19, MERS, [키워드] acute lung injury acute respiratory syndrome adverse effect Anti-inflammatory anti-oxidative Anxiety ARDS Care caused clinical Clinical features Clinical outcome clinical trial clinical trials contribute coronavirus Coronaviruses COVID-19 COVID-19 pandemic critical care patient Cytokine storm death disease distress effective Evidence exaggerated immune response excessive inflammation Health homogenous humans immune response imperative individual Inflammation melatonin pandemic of COVID-19 Pathogenesis pathology patients professional progression reducing reported respiratory disorder safety profile SARS-CoV-2 Sedation subsequent syndrome Treatment triggering vascular permeability [DOI] 10.3390/nu12092561 PMC 바로가기 [Article Type] Review
A Meta-Analysis on the Effects of Hydroxychloroquine on COVID-19Internal Medicine Published on 2020-08-242022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome adhere adverse effect Analysis analyzed article Azithromycin Chloroquine Clinical outcome Cochrane Library control group coronavirus COVID-19 disease disease severity Effect effort eligibility criteria eligible exclusion criteria Google Scholar greater group HCQ Healthcare professional Hydroxychloroquine Inclusion independent item Meta-analysis Mild moderate mortality rate outcome measure overall mortality pandemic participant patients with COVID-19 Prevent public health crisis Reporting review SARS-CoV-2 screened selected Side effect Spread Symptom Transmission treat treated treated patient virus was performed WHO World Health Organization [DOI] 10.7759/cureus.10005 PMC 바로가기 [Article Type] Internal Medicine
Pediatric massage therapy for restoring pediatric lung function from COVID-19 A protocol for systematic review and meta-analysis3800 Published on 2020-08-142022-10-30 Journal: Medicine [Category] Coronavirus, MERS, [키워드] adverse effect Blood caused children CINAHL circulation CNKI complementary and alternative medicine convalescent COVID-19 data extraction database Effectiveness evaluate Evidence global public health help include International Lung function medical system meta-analyses Meta-analysis novel coronavirus disease outbreak outcome pandemic Pathogens Patient pediatric pediatric massage promote protocol Pulmonary function Respiratory illness risk of bia searched self-quarantine survival Symptom systematic review therapy Wuhan, China [DOI] 10.1097/MD.0000000000021581 PMC 바로가기 [Article Type] 3800
Public Health Lessons Learned From Biases in Coronavirus Mortality OverestimationConcepts in Disaster Medicine Published on 2020-08-122022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, [키워드] 10-times higher adverse effect benefit Biase Case fatality rate caused center Committee congress Control coronavirus coronavirus mortality overestimation COVID-19 critical appraisal disease Evidence Fatality rate Health house Infection fatality rate Infectious disease influenza infection information lesson measure Mortality Novel coronavirus Pandemics prevention Public public health reform Research Result risk Sampling bias Seasonal influenza selection bia Validity Viral transmission World Health Organization [DOI] 10.1017/dmp.2020.298 PMC 바로가기 [Article Type] Concepts in Disaster Medicine
Small Molecule Inhibitors in the Treatment of Rheumatoid Arthritis and Beyond: Latest Updates and Potential Strategy for Fighting COVID-19Review Published on 2020-08-112022-10-31 Journal: Cells [Category] COVID-19, MERS, [키워드] Activation administration adverse effect blood test Clinical efficacy clinical trials COVID-19 Cytokine storm demonstrated downstream drug event Fighting highlight hyperimmune implication Infection jak inhibitors kinases management molecule outbreak Pathways Potential pro-inflammatory pro-inflammatory molecules provided reducing Rheumatoid rheumatoid arthritis risk SARS-CoV-2 Side effects Signaling signaling pathways small molecule small molecule inhibitor Small molecule inhibitors Strategy Thromboembolism Treatment tsDMARDs viral entry viral infection [DOI] 10.3390/cells9081876 PMC 바로가기 [Article Type] Review
A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial중환자실에 입원한 COVID-19 환자의 정맥 주사 멜라토닌의 효능과 안전성을 조사하기 위한 2상, 단일 센터, 이중 맹검, 무작위 위약 대조 시험(MelCOVID 연구): 연구 프로토콜의 구조화된 요약 무작위 대조 시험을 위해Letter Published on 2020-08-052022-08-13 Journal: Trials [Category] MERS, 임상, [키워드] 6 hours Acute hypoxemic respiratory failure addition Admission Adult patients adverse effect adverse event adverse events age allocation anticipated Autoimmune disease Biochemical parameters blinded Blinding blood gas blood gas analysis body weight C-reactive protein Caregivers carried chronic Chronic kidney disease clinical condition clinical development commercialization comparator compatible symptom compatible symptoms Complete completion computer conducted Confirmed Consent Control control arm control group COVID-19 COVID-19-associated thromboembolic phenomena Critically ill D-dimer daily dose Date determined by disease dissemination double-blind Efficacy and safety element enzyme EU Clinical Trial evaluate evaluate the effect exclusion criteria expected experimental arm experimental group failing organ failing organs family member ferritin Frequency gas analysis GFR greater hematologic Hemodialysis hypoxemic Hypoxemic respiratory failure ICU ICU admission impairment Inclusion inclusion criteria increase in inflammatory state Informed institutional protocols intensive care intensive care unit interleukin interleukin-6 intravenous Kidney disease legal guardian less liver enzymes maximum mechanical ventilation medical illness melatonin Mortality multi-organ failure normal range number objective Organ failure outcome parameters participant Patient patient condition patients with COVID-19 per day performed phase physician Placebo placebo-controlled randomized trial plasma Plasma levels positive RT-PCR Pregnancy pregnancy test Prevent procalcitonin Program protocol provided randomization randomization sequence Randomized Randomized controlled trial randomized placebo-controlled trial receive recruited recruitment reduced reduction Respiratory failure Sample size SARS-COV-2 infection SAS version 9.4 SAS version 9.4 statistical software secondary Secondary objectives Sequential Organ Failure Assessment severity single center single-center SOFA Spain Stage Standard-of-care statistical status study drug study group study groups study period Study protocol systemic inflammatory response Terminal surgical thromboembolic Treatment Trial Trial registration two-arm parallel Ventilator-free days website with COVID-19 worsening written Informed Consent [DOI] 10.1186/s13063-020-04632-4 PMC 바로가기 [Article Type] Letter