Dexamethasone – Page 47 – Communicable Diseases Research

A Revisit to the Research Updates of Drugs, Vaccines, and Bioinformatics Approaches in Combating COVID-19 Pandemic

Molecular Biosciences

Published on 2021-01-252022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] in silico approaches acute respiratory syndrome approach approved drug bioinformatics candidate drug China Chinese clinical clinical symptom confirmed case coronavirus coronavirus disease country CoV COVID-19 death Dexamethasone dosage drug drug target drugs effective effective drug Effectiveness European global public health homology Human human clinical trial Hydroxychloroquine identify in silico Approach library limitation Medicine MERS Middle East MMR molecular molecular docking mump new strain other coronaviruses pandemic pathogenesis of COVID-19 Pathogens Potential recorded registry Remdesivir repurposing researcher respiratory syndrome coronavirus responsible Revisit SARS-CoV-2 Side effects Therapies Trial union Vaccine Vaccines website Wuhan
[DOI] 10.3389/fmolb.2020.585899 PMC 바로가기 [Article Type] Molecular Biosciences

Molecular docking studies of some selected gallic acid derivatives against five non-structural proteins of novel coronavirus

Research

Published on 2021-01-252022-10-30
Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19,

[키워드] 3D structure binding energy Cardiomyopathy Chloroquine clinical trial Compound COVID-19 COVID-19 infected patient crystal structure database derivative detrimental Dexamethasone disease docked drug Druglikeness drugs Favipiravir FIVE Gallic acid derivatives health emergency Hydroxychloroquine in silico in vitro study in vivo inhibitor Ivermectin liver lower binding energy molecular molecular docking Molecular docking study molecular interactions MPro New coronavirus non-structural protein non-structural proteins Novel coronavirus Nsp12 nsp13 nsp14 Nsp15 Nsp3 pandemic PDB phosphate Plasma Protein Binding Protein Proteins PubChem Remdesivir reported Result retrieved ribavirin SARS-CoV-2 selected Side effect small molecule small molecule inhibitor Support therapeutic compound Vaccine virus World Health Organization
[DOI] 10.1186/s43141-021-00120-7 PMC 바로가기 [Article Type] Research

Survival benefit of ixazomib, lenalidomide and dexamethasone (IRD) over lenalidomide and dexamethasone (Rd) in relapsed and refractory multiple myeloma patients in routine clinical practice

Research Article

Published on 2021-01-152024-09-02
Journal: BMC Cancer [Category] 대상포진,

[키워드] clinical trial Dexamethasone Ixazomib lenalidomide Multiple myeloma Patient registry
[DOI] 10.1186/s12885-020-07732-1 PMC 바로가기 [Article Type] Research Article

Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study

Research Paper

Published on 2021-01-152022-10-28
Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS,

Case Report: Late-Onset Congenital Adrenal Hyperplasia and Acute Covid-19 Infection in a Pregnant Woman: Multidisciplinary Management

Endocrinology

Published on 2021-01-152022-10-31
Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS,

Effects of Continuous Epidural Injection of Dexamethasone on Blood Glucose, Blood Lipids, Plasma Cortisol and ACTH in Patients With Neuropathic Pain

Original Research

Published on 2021-01-132024-09-02
Journal: Frontiers in Neurology [Category] 대상포진,

[키워드] ACTH blood glucose cortisol Dexamethasone epidural space
[DOI] 10.3389/fneur.2020.564643 PMC 바로가기 [Article Type] Original Research

Association between high-dose steroid therapy, respiratory function, and time to discharge in patients with COVID-19: Cohort study

고용량 스테로이드 요법, 호흡 기능, COVID-19 환자의 퇴원 시간 사이의 연관성: 코호트 연구

Observational Study

Published on 2021-01-082022-09-11
Journal: Medicina clínica [Category] 바이오마커, 임상,

[키워드] adjusted Analysis association Cohort cohorts control patients coronavirus COVID-19 Cox multivariate model Cox multivariate models Cox regression Dexametasona Dexamethasone discharge doses Evolution glucocorticoid Glucocorticoides Glucocorticoids hazard ratio High-dose hospital increment log-rank Methylprednisolone Metilprednisolona multivariate no significant difference observational study oxygen Patient patients hospitalized patients treated Primary outcomes Prognostic factors Respiratory function SAFI SARS-CoV-2 significant difference significantly Spain sub-cohort therapy Treatment treatments for COVID-19 with COVID-19
[DOI] 10.1016/j.medcli.2020.08.003 PMC 바로가기 [Article Type] Observational Study

Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic

Review

Published on 2021-01-082024-09-04
Journal: European journal of pharmacology [Category] 대상포진,

[키워드] acute respiratory distress syndrome (ARDS) Corticosteroid COVID-19 therapeutics Dexamethasone Immunosuppressant SARS-CoV-2
[DOI] 10.1016/j.ejphar.2021.173854 PMC 바로가기 [Article Type] Review

The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection

Observational Study

Published on 2021-01-082022-10-04
Journal: Frontiers in Endocrinology [Category] MERS, 임상,

[키워드] ACE2 ACE2 receptor adrenal cortex Adrenal insufficiency aggravate analyzed Cell cells clinical feature collected Concentration Coronavirus disease 2019 cortical Corticosteroid COVID-19 criteria Critical Critically ill Critically ill patient critically ill patients death Dexamethasone Diagnosis examined hormonal therapy IMPROVE Infection majority nine Non-COVID-19 observational studies plasma random recent reduce reported Result SARS-CoV-2 serine protease serum severe acute respiratory syndrome coronavirus 2 Site staining therapeutic effect TMPRSS2 TMPRSS2 expression treated vasopressors with COVID-19
[DOI] 10.3389/fendo.2020.593179 PMC 바로가기 [Article Type] Observational Study

Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2

Research Article

Published on 2021-01-072022-10-27
Journal: BMC Medical Informatics and Decision Making [Category] COVID-19,

[키워드] activated addition affected Analysis approach caused clinical trials coronavirus 2 COVID-19 COVID-19 patient Critical Data analysis death rate Dexamethasone drug drug-target effective effective drug epithelial cell ERK evaluated facilitate Gene Expression high mortality rate host cell host cells human lung identify immune Infection Integrative analysis involved Jak-STAT JNK MAPK molecular Ontology pandemic pathway receiving reduce reported Repurposed drug resources respiratory Respiratory Support Result SARS-CoV-2 Signaling signaling pathway significantly STAT therapy transcriptional response Treatment treatments for COVID-19 Vaccine
[DOI] 10.1186/s12911-020-01373-x PMC 바로가기 [Article Type] Research Article