Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patientsMulti-omic 접근법은 COVID-19 암 환자의 혈액에서 증식에 대한 타고난 면역 반응을 결합하는 전사 네트워크를 식별합니다.Article Published on 2021-10-292022-09-12 Journal: Cell Death & Disease [Category] MERS, 임상, 진단, [키워드] Alter alteration analyses Analysis analyzed approach Blood Cancer cancer patient Cancer patients cancer type CD4 CD8 Cell cell population central memory circulating clinical co-morbidities Cohort conducted contribute controls COVID-19 COVID-19 disease COVID-19 patient cytokine Cytometry Diseases Donor eight elevated enrichment analysis expression Gene Expression Genes highlight homeostasis identify IL-13 IL-6 IL-8 Immune cell immune function immune system immunological parameter immunology Infection Infectious diseases inflammation response innate immune response investigated IP-10 modulated mononuclear cell mortality rates multiplex natural killer outcome Patient PBMC PBMCs performed Peripheral blood plasmablast pro-inflammatory factor proliferation reduced Regulation SARS-COV-2 infection serum cytokine Signaling solid cancers Stage subpopulation T cell T lymphocyte transcriptional worsened [DOI] 10.1038/s41419-021-04299-y PMC 바로가기 [Article Type] Article
Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19Article Published on 2021-10-292022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute COVID-19 acute infection anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies association baseline Concentration COVID-19 COVID-19 patient COVID-19 severity criteria Cytokines cytokines IL-6 Diagnosis disease eight hospitalized COVID-19 patient Host ICU IFN-γ IgA IgG IgG antibodies IgM IL-1β IL-6 IL-8 immune intensive care Laboratory male median age MIP-1α MIP-1β MOST outcome persistence predictor Proinflammatory cytokine SARS-CoV-2 SARS-CoV-2 RNA severe COVID-19 severe COVID-19 disease Symptom Viral load were measured [DOI] 10.3390/microorganisms9112259 PMC 바로가기 [Article Type] Article
The Effects of Elastic Band Exercises with PNF on Shooting Speed and Accuracy in Ball Hockey Players during the COVID-19 PandemicRandomized Controlled Trial Published on 2021-10-292022-10-04 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 임상, [키워드] Accuracy Affect affected age Ball ball hockey band Characteristics control group coronavirus COVID-19 COVID-19 pandemic decrease Deterioration Effect eight Elastic elastic resistance element evaluate exercise exercises experiment experimental group facilitation maintain Neuromuscular no decrease not significant pandemic per day performed proprioceptive neuromuscular facilitation randomly divided resistance exercise Shooting shooting accuracy shooting speed speed statistically significant were measured [DOI] 10.3390/ijerph182111391 PMC 바로가기 [Article Type] Randomized Controlled Trial
A Study Protocol to Assess the Respiratory Health Risks and Impacts amongst Informal Street Food Vendors in the Inner City of Johannesburg, South AfricaStudy Protocol Published on 2021-10-282022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] Act addition city condition conducted coronavirus COVID-19 cross-sectional disease eight environmental health FIVE food Health healthy hygiene Impact impacted include indicated informal Inner Johannesburg lack management occupational occupational health pandemic pilot study Protective Quantitative questionnaire Regulation respiratory respiratory symptom respiratory symptoms and diseases risk Risk assessment risk factor Safety smoking South Africa Street street vendors Transport Vendor [DOI] 10.3390/ijerph182111320 PMC 바로가기 [Article Type] Study Protocol
Results of WICOVIR Gargle Pool PCR Testing in German Schools Based on the First 100,000 TestsPediatrics Published on 2021-10-282022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] addition analyzed Antigen average children Cohort consequence COVID-19 COVID-19 pandemic Ct value detection rate effective eight gargle Germany hygiene Laboratory measure opening pandemic Participants PCR performed pool pooling positive positive sample Positive test PROTECT protocols Result rRT-PCR rRT-PCR testing Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 testing School Schools sensitivity significantly Test Testing transmitted was performed [DOI] 10.3389/fped.2021.721518 PMC 바로가기 [Article Type] Pediatrics
Surgical Diseases Management during COVID-19 Crisis at a Tertiary Care Hospital of India: Our Institutional StrategyOriginal Article Published on 2021-10-282022-10-28 Journal: The Surgery Journal [Category] COVID-19, [키워드] adjust Cancer Care Clinical data collected condition coronavirus disease COVID-19 COVID-19 crisis COVID-19 infection crisis demographics diagnoses effective strategy eight Elective Emergency hospital Hospitalization Infection Intervention lockdown malignancy management material measure medical record multiorgan failure National Operating room operative procedure operative treatment outcomes pandemic Patient patients died performed Precaution provided radiologic reduce remained required resources Result Safe selected Sepsis spread of COVID-19 Strategy surgery surgical Surgical Procedure Tertiary [DOI] 10.1055/s-0041-1740452 PMC 바로가기 [Article Type] Original Article
Molecular mimicry of NMDA receptors may contribute to neuropsychiatric symptoms in severe COVID-19 casesNMDA 수용체의 분자 모방은 심각한 COVID-19 사례에서 신경 정신병 증상에 기여할 수 있습니다Review Published on 2021-10-282022-09-12 Journal: Journal of Neuroinflammation [Category] MERS, SARS, 진단, [키워드] Agitation Altered mental status antibody auditory auditory hallucination autoantibody Autoimmune Autoimmune encephalitis catatonia cerebrospinal fluid characteristic condition confirmed case confirmed cases Confusion contribute Corticosteroid COVID-19 develop diagnostics dysfunction eight Encephalitis feature Hallucination High-dose Immunoglobulin Immunomodulatory agent Immunotherapy individual Infection Inflammation memory molecular mimicry neurological Neuropsychiatric NMDA NMDA receptor Occurrence Patient performed Psychiatric receptor reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 severe SARS severe SARS-CoV-2 steroid supplementary material Symptom Symptoms systematic review treated Working memory [DOI] 10.1186/s12974-021-02293-x PMC 바로가기 [Article Type] Review
Prevalence and patterns of physical activity, sedentary behaviour, and their association with health-related quality of life within a multi-ethnic Asian populationResearch Published on 2021-10-252022-10-28 Journal: BMC Public Health [Category] Coronavirus, MERS, SARS, [키워드] activity age analyses Asian association Attitude calculated complex conducted COVID-19 cross-sectional Descriptive statistics domain eight examined form General population GPAQ groups Increased Insufficient likelihood Linear regression lockdown logistic regression model Mental moderate Multimorbidity obesity objective participant physical physical activity Practice Prevalence promote Quality of life recruited reported Result sedentary behaviour Seven significantly Singapore Sociodemographic supplementary material survey were assessed [DOI] 10.1186/s12889-021-11902-6 PMC 바로가기 [Article Type] Research
Seven days treatment with the angiotensin II type 2 receptor agonist C21 in hospitalized COVID-19 patients; a placebo-controlled randomised multi-centre double-blind phase 2 trialResearch article Published on 2021-10-252022-10-05 Journal: EClinicalMedicine [Category] 임상, 치료법, [키워드] acute hospitalizations addition Analysis angiotensin II type 2 receptor assigned conducted COVID-19 CRP double-blind effective drug Efficacy eight evaluate Fewer patient finding funding groups hospitalised patient hospitalized COVID-19 hospitalized patient India indicated mechanical ventilation morbidity and mortality mortality rate oxygen parallel group Patient patients pharmacologic treatment phase phase 2 trial Placebo placebo group placebo-controlled post-hoc analysis proportion randomisation randomised Randomly receiving receptor reduction reduction in required requiring supplemental oxygen Safe Standard of care study period supplemental oxygen the patient Treatment Trial Vaccines Viral pneumonia was reduced with COVID-19 [DOI] 10.1016/j.eclinm.2021.101152 [Article Type] Research article
COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian HospitalColumbia University Irving Medical Center/New York Presbyterian Hospital의 코로나19 신경병리학Article Published on 2021-10-222022-09-11 Journal: Brain : a journal of neurology [Category] MERS, SARS, 진단, 치료법, [키워드] accompanied Activation Acute kidney injury Admission age alterations antibody arteriolosclerosis Artery Atherosclerosis Autopsy Blood Brain brains Brainstem changes in Columbia University Complication consecutive patient contribute coronavirus disease Coronavirus disease 2019 COVID-19 Culture Deep vein Deep vein thrombosis detect detectable develop dialysis died direct viral infection Diseases during admission eight epithelia Evidence evidence of examined exhibited fixed histopathological Hospital admission hypoxia immunocytochemistry Infection intensive care intensive care unit lymphocyte majority male microglia microglia activation microglial microglial nodules molecular nasal neurodegenerative neurological problems neurological sign neurological signs Neuronophagia Neuropathology nodule nucleocapsid Pathologies pathology Patient patients patients died patients with SARS-CoV-2 PCR analysis perivascular positive Primary infection Primers probe probes Protein Pulmonary embolism Quantitative Region regions reverse-transcriptase PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Seven Signs and symptoms synergistic systemic inflammation T lymphocyte tissue to define Vasculitis Viral Viral RNA virus York [DOI] 10.1093/brain/awab148 PMC 바로가기 [Article Type] Article