Inactivated vaccine injection and immunoglobulin G levels related to severe coronavirus disease 2019 (Delta) pneumonia in Xi’an, China: A single-centered, retrospective, observational studyArticle Published on 2022-08-232022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome analyzed B.1.617.2 booster booster shot Chinese coronavirus coronavirus disease COVID-19 COVID-19 severity Critical death Delta delta variant effective Efficacy Epidemic evaluate Hospitalization IgG antibody IgG level immune response Immunoglobulin Immunoglobulin G Inactivated vaccine Infection infections injection International logistic regressions men Mild moderate Older Patient patients with COVID-19 Pneumonia PROTECT protective effect public health emergency retrospective Retrospective study risk severe cases severe coronavirus disease severity underlying diseases Vaccine vaccine injection World Health Organization [DOI] 10.3389/fcimb.2022.933100 PMC 바로가기
Human coronaviruses disassemble processing bodiesArticle Published on 2022-08-232022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] 229E caused cells characteristic common cold CoVs contribute coronavirus Coronavirus infection correlated CoVs cytokine cytoplasmic dysregulated dysregulation expression FIVE fluorescent Granule Human human coronavirus IL-6 immune response impacted infected cell Infection information innate immune response mechanism MERS mRNA transcripts NL63 OC43 processing Proinflammatory cytokine proinflammatory cytokines promote Protein respond responsible ribonucleoprotein RNA RNAs SARS-CoV SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein screened severe SARS-CoV-2 stability submission the N protein the viral nucleocapsid TNF transcript translation unique viral infection virus [DOI] 10.1371/journal.ppat.1010724 PMC 바로가기
Mitochondria in Mycobacterium Infection: From the Immune System to Mitochondrial Haplogroups미코박테리아 감염에서의 미토콘드리아: 면역 시스템에서 미토콘드리아 하플로그룹까지Article Published on 2022-08-232024-08-24 Journal: International Journal of Molecular Sciences [Category] 한센병, [키워드] Bacterial infection haplogroups immune response M. leprae M. tuberculosis Mitochondria mycobacteria
Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is keyArticle Published on 2022-08-222022-11-16 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] age cellular cellular heterogeneity Clinical outcome clinical outcomes Comorbidities complex correlation COVID-19 COVID-19 disease COVID-19 disease severity disease severity dysregulation functional Gender genetics granular heterogeneity heterogeneous heterogeneous population highlight Host host response identify immune immune cells Immune profile immune response immunological mechanism impairment Infectious disease information pandemic Patient progression regulated RNA-Seq severity single-cell genomics single-cell genomics. subset the disease with COVID-19 [DOI] 10.3389/fimmu.2022.973070 PMC 바로가기
Insights into induction of the immune response by the hepatitis B vaccineReview Published on 2022-08-212023-06-11 Journal: World journal of gastroenterology [Category] B형 간염, [키워드] antibodies Hepatitis B virus immune response Neutralizing Vaccine [DOI] 10.3748/wjg.v28.i31.4249 PMC 바로가기 [Article Type] Review
Humoral immune response characterization of heterologous prime-boost vaccination with CoronaVac and BNT162b2CoronaVac 및 BNT162b2를 사용한 이종 프라임-부스트 백신 접종의 체액 면역 반응 특성화Article Published on 2022-08-192022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome ADCC ADCP Analysis anti-RBD anti-RBD IgG antibody antibody Antibody binding assays baseline binding domain binding kinetics BNT162b2 booster Cohort CoronaVac coronavirus decrease dose elapsed enrolled evaluated Fc-mediated function Fc-mediated functions Follow-up General population healthy individual Heterologous heterologous prime-boost heterologous vaccination high correlation humoral immune response IgG antibody IgG level immune immune response increase in individual Interaction mechanisms Neutralization assay Participants Prevent Prospective Study RBD RBD-ACE2 remained reporter SARS-CoV-2 SARS-COV-2 infection Seroconversion serological seronegative serum severe infections significantly to define vaccination vaccination schedule Vaccine [DOI] 10.1016/j.vaccine.2022.07.023 PMC 바로가기 [Article Type] Article
A platform technology for generating subunit vaccines against diverse viral pathogensArticle Published on 2022-08-182022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] acting affinity tag animal model Antigen binding can be used Clamp conformation COVID-19 pandemic Ebola virus elicit epitope fusion fusion protein glycoprotein immune response immunologically Infectious disease MERS-CoV Microscopy middle molecular monoclonal antibody mRNA neutralising Neutralising Antibodies Nipah virus offer platform precursor prefusion purification reagent remained respiratory syndrome coronavirus shown size exclusion chromatography stability stimulated Streamline subunit Subunit vaccine subunit vaccines tested trimeric Vaccine vaccine candidate vaccine platform Viral Viral antigen viral challenge viral pathogen virus [DOI] 10.3389/fimmu.2022.963023 PMC 바로가기
BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19COVID-19에 대한 이종 또는 동종 ChAdOx1nCoV-19/BNT162b2 백신 접종 후 6개월 후 BNT162b2로 강화된 면역 반응Article Published on 2022-08-182022-09-11 Journal: Nature Communications [Category] SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] Alpha anti-Spike IgG approach B.1.1.529 Beta BNT BNT162b2 both groups CD4 CD8 Cell ChAd choice compensated delta variant Delta variants Effect followed by Frequency Gamma Heterologous homologous immune response immune responses Immunity in both groups increase in moderate mRNA vaccine Neutralizing activity Neutralizing antibody response neutralizing antibody responses omicron protective immunity repeated reported SARS-CoV-2 second vaccination subsequent T cell vaccinated individual vaccinated individuals vaccination vaccination against COVID-19 Vaccine variant virus [DOI] 10.1038/s41467-022-32527-2 PMC 바로가기 [Article Type] Article
A randomised, double-blind, placebo-controlled, multicentre clinical trial of AZD1656 in diabetic patients hospitalised with COVID-19: The ARCADIA Trial – implications for therapeutic immune modulationResearch article Published on 2022-08-182022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 변종, 임상, [키워드] 1:1 Activation Adaptive immune response addition adverse event ARCADIA assigned AZD1656 Clinical improvement clinical trial Complete COVID-19 cytokine Czech Republic Day death decrease diabetes diabetic patient diabetic patients dose double-blind duration of hospitalisation Efficacy Excalibur False positive finding Full Analysis Set funding Glucokinase activator group homeostatic hospital hospital discharge hospitalised identify immune Immune cell immune modulation immune response Immunochemistry immunomodulatory effect Immunophenotyping implication indicated Innovation investigated involved less Medicine multicentre nine no difference Patient phase Phase 2 Placebo placebo-controlled placebo-controlled clinical trial primary analysis primary endpoint pro-inflammatory randomised Randomly receive recruited reduction in Registered regulatory T cells required risk Romania SARS-CoV-2 screened statistically significant difference suggested Tablet the placebo group therapeutic therapeutic effect treated Treatment treatment allocation Tregs Trial usual care with COVID-19 [DOI] 10.1016/j.eclinm.2022.101604 [Article Type] Research article
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes Research Published on 2022-08-172022-10-05 Journal: Communications Biology [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme-2 attenuate cause coronavirus COVID-19 COVID-19 patients cytopathic effects Deprivation Evidence exacerbated expressed expressing Fatty liver full-length Glycolysis hACE2 hepatic dysfunction hepatocyte hepatocytes Human humanized hyperglycemia immune response include increase Infection infection with SARS-CoV-2 Inflammation inhibition Injury metformin methionine mice mitochondrial Multi-organ damage Patient promote pseudotyped viral particles pseudovirus RBD Receptor binding domain reduce renin-angiotensin system SARS-CoV-2 steatosis susceptibility susceptible therapeutic option Toxicity type 2 diabete viral particle [DOI] 10.1038/s42003-022-03789-9 [Article Type] Research