Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome as a Presentation of Coronavirus Disease 2019Emergency Medicine Published on 2020-04-242022-10-31 Journal: Cureus [Category] COVID-19, [키워드] av nodal blockers blockade bradycardia brash syndrome Coronavirus disease 2019 COVID-19 end-organ damage failure global pandemic hyperkalemia novel coronavirus disease predominant presentation renal renal failure Respiratory failure sars-cov-2 (severe acute respiratory syndrome coronavirus -2) Shock syndrome triggered while [DOI] 10.7759/cureus.7816 PMC 바로가기 [Article Type] Emergency Medicine
Lobar Distribution of COVID-19 Pneumonia Based on Chest Computed Tomography Findings; A Retrospective StudyOriginal Research Published on 2020-04-182022-10-27 Journal: Archives of Academic Emergency Medicine [Category] COVID-19, [키워드] Admission Affect age cavitation chest CT scan consolidation coronavirus disease COVID-19 demographic diagnosis of COVID-19 distribution Dyspnea evaluate evaluated feature Final GGO hallmark indicate Infection investigated involved left lower lobe lobar lower lobe lung Lung injury lung lesion Lungs male Mild nodule nodules Patient patients patients with COVID-19 performed Pneumonia predominant reported Retrospective study reversed right lower lobe severity Sex significantly stages Symptom the patient tomography Viral X-ray computed PMC 바로가기 [Article Type] Original Research
Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China중국 우한에서 2019년 신종 코로나바이러스에 감염된 환자의 사망률과 방사선학적 소견의 연관성Research Article Published on 2020-03-192022-08-13 Journal: PLoS ONE [Category] COVID-19, Medicine and Health Sciences, MERS, [키워드] 2019 novel coronavirus 2019-nCoV air bronchogram association bronchogram Characteristics Clinical characteristics collected Comorbidities Comorbidity consecutive patient consolidation consolidations CT finding CT findings cutoff value diagnosing discharged distribution distributions evaluated Frequency Ground glass opacity hospital infect involved IQR lung median median age men Mortality mortality group nCoV Novel coronavirus Patient patients died Pneumonia predict predominant Prognosis radiologic retrospective sensitivity significantly higher specificity survival group women Wuhan, China zone [DOI] 10.1371/journal.pone.0230548 PMC 바로가기 [Article Type] Research Article
A molecular barcode to inform the geographical origin and transmission dynamics of Plasmodium vivax malariaPlasmodium vivax 말라리아의 지리적 기원과 전파 역학을 알려주는 분자 바코드Research Article Published on 2020-02-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] applied approach barcode characterising country develop DNA dormancy dormant effort Elimination Endemic Epidemiology events Genetic genetic marker genetics genotyping human liver identify Inclusion Infection infections life-threatening liver Local malaria Malaysia marker molecular Molecular genetics movement New not used outbreak outperform parasite parasites Plasmodium vivax Plasmodium vivax malaria Population predicted Predictive predominant reservoir reservoirs risk of infection SNP SNP genotype sub-Saharan Africa targeted intervention targeted interventions targeting Transmission Transmission dynamics Variability vivax malaria whole genome sequence widespread [DOI] 10.1371/journal.pgen.1008576 PMC 바로가기 [Article Type] Research Article
Respiratory viruses in individuals with a high frequency of animal exposure in southern and highland VietnamResearch Article Published on 2019-12-122022-10-30 Journal: Journal of medical virology [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] acute respiratory disease Asymptomatic baseline cohort study collected conducted detect disease ecological enrolled EVs example fluctuation Frequency hotspot individual Infectious disease influenza A influenza A virus Intervention outbreak predominant reported respiratory Respiratory disease respiratory infection respiratory virus responses rhinovirus study period Surveillance Swab Vietnam viral etiology virus zoonoses zoonotic [DOI] 10.1002/jmv.25640 PMC 바로가기 [Article Type] Research Article
Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antiviralsC형 간염 바이러스는 직접 작용하는 항바이러스제에 의한 감염 치료 후 후성 유전적 특징을 남깁니다.Research Article Published on 2019-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting Alter alteration Anti-HCV Antiviral approach Biomarker Cell cells change changes in characterized Chemotherapy ChIP-seq chromatin chromatin immunoprecipitation chronic hepatitis develop direct-acting antiviral disease drug Effect EGFR EGFR Inhibitor enzyme Epidemiological study Epigenetic Erlotinib Europe expected explain expression followed by gene signature Genome HCC HCV Hepatitis hepatitis C hepatitis C virus Hepatocellular carcinoma histone Hit and run host gene expression identify in vitro induce infected case infected patient Infection inhibit inhibitor interferon life cycle liver Liver Biopsy marker mechanism Modification molecular mechanism Mortality Multiple Multiple epidemiological studies Next-generation sequencing observation offer oncogenic outcome Pathogenesis pathogenic Pathways Patient persist poor prognosis post-translational modification predominant Prevalence proceed replaced repressed risk risk factor RNA signaling pathway specific inhibitor specific inhibitors sustained the cells therapeutic target therapy Treatment Tumor unmet need Viral protein Viral proteins virological response virus while [DOI] 10.1371/journal.pgen.1008181 PMC 바로가기 [Article Type] Research Article
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the “endemic Burkitt Lymphoma belt”"풍토병 Burkitt 림프종 벨트"의 사하라 사막 이남 인구에서 유전자 흐름과 말라리아에 의한 자연 선택의 유전 적 특징Research Article Published on 2019-03-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] Affect African Analysis association ATP2B4 baseline Burkitt lymphoma calcium Cancer characterization characterized chronic infection coding complex confluence determine disease East Effect Endemic erythrocytes event Evidence evidence of expressed facilitate gene flow Genetic genomic genomic data genotyped Great Lake Great Lakes group groups highest Hypothesis incidence individual intensity malaria Migration mixture natural natural selection North occurred Occurrence opposite pediatric Population populations Positive selection predominant SNP sub-Saharan Africa Support Transmission Uganda West [DOI] 10.1371/journal.pgen.1008027 PMC 바로가기 [Article Type] Research Article
De novo and inherited private variants in MAP1B in periventricular nodular heterotopia심실주위 결절성 이형에서 MAP1B의 드 노보 및 유전된 사적 변이체Research Article Published on 2018-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abnormality affected allele Analysis arising association Author Brain brain development caused chance Collapsing controls cortical de novo de novo mutation de novo mutations detrimental Diseases disorder driven by ENCODE epilepsy Exome exome sequencing expected explain fetal Genetic genetic risk Genetic variant genetic variants genome-wide significant heterozygous variant identify implicated incomplete penetrance indicate individual initial involved leads list of gene loci loss-of-function malformation MAP1B Migration Mutation Neuron neurons nonsynonymous occur one patient parent parents patients performed predominant Protein responsible sequence sequenced Sequencing the disease the patient transmitted variant variants [DOI] 10.1371/journal.pgen.1007281 PMC 바로가기 [Article Type] Research Article
Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus삼투성 항상성의 순환 di-AMP 조절은 B군 연쇄상 구균에서 필수적입니다Research Article Published on 2018-04-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulating accumulation assumed Bacteria Bacterial betaine bind binding cellular cellular physiology compensatory mutations conditions conserved Control cyclic dacA Deletion demonstrated dependent on enzyme etiological agent expression function functional glycine glycine betaine group growth homeostasis host cell host cells host-pathogen interactions hyperosmotic identification identify Infection involved leads Loss loss-of-function loss-of-function mutation maintain mechanism medium Meningitis monophosphate mutant Mutation Neonatal nucleotide nucleotides opportunistic pathogen osmolyte osmoregulation osmotic osmotic regulation pathogen pathway phenotype Potassium predominant promoter Protein regulate Regulation second messenger second messengers secondary messenger septicaemia Streptococcus Streptococcus agalactiae susceptibility Transcription transcriptional viability [DOI] 10.1371/journal.pgen.1007342 PMC 바로가기 [Article Type] Research Article
Human coronavirus circulation in the United States 2014–2017 ☆Article Published on 2018-01-312022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, [키워드] age age and sex annual variation calculated circulation common coronavirus described distribution enteric Epidemiology groups HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 Human infections Laboratory Lower respiratory tract National objective OC43 peaked polymerase chain positive Positive test predominant Prevalence reported respiratory respiratory tract infection respiratory virus Result reverse transcription rRT-PCR Sex shown significant difference square submission subset System tested the patient the United State [DOI] 10.1016/j.jcv.2018.01.019 PMC 바로가기 [Article Type] Article