Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera Research Published on 2021-02-082022-10-05 Journal: Nature Medicine [Category] SARS, 변종, [키워드] acute respiratory syndrome African BNT162b2 coronavirus doses E484K Effect elicited geometric mean titer GMT GMTs human sera mutant virus Mutation N501Y neutralization parental SARS-CoV-2 SARS-CoV-2 spike sera South spike mutation United Kingdom variant virus [DOI] 10.1038/s41591-021-01270-4 [Article Type] Research
Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal ImmunizationArticle Published on 2021-02-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antigens avian coronavirus Bronchoalveolar lavage Coronaviruses COVID-19 cytokine elicit elicited expressing global pandemic Heterologous heterologous vaccine homologous Homologous vaccine IFN-γ IL-2 immune response Immunity immunization intranasal intranasal vaccine Local Localized lung mice mucosal mucosal immune nanovaccine neutralizing antibody nucleocapsid Plasmid Protective response responses against robust SARS-CoV-2 SARS-CoV-2 spike secreting serum spleen Support systemic T-cell T-cell Response TNFα transmission of SARS-CoV-2 USA Vaccine vaccinia [DOI] 10.3390/vaccines9020132 PMC 바로가기 [Article Type] Article
Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2Article Published on 2021-02-052022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] ACE2 receptors bat bat ACE2 bind binding coronavirus cryo-EM structure Cryoelectron microscopy Evolution Evolution of SARS-CoV-2 exhibit Guangdong implicated pandemic pangolin RaTG13 SARS-CoV-2 SARS-CoV-2 spike spike spike glycoprotein Spike protein Structure suggested [DOI] 10.1038/s41467-021-21006-9 PMC 바로가기 [Article Type] Article
Evaluating SARS-CoV-2 spike and nucleocapsid proteins as targets for antibody detection in severe and mild COVID-19 cases using a Luminex bead-based assayLuminex 비드 기반 분석을 사용하여 중증 및 경증 COVID-19 사례에서 항체 검출을 위한 표적으로 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질 평가Article Published on 2021-02-012022-09-11 Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody detection Antibody test Antigen assays Bead-based assay Combination coronavirus COVID-19 case domain ELISA Evaluating FIVE IgA antibodies IgA antibody IgA response IgG IgG antibody IgM include Infection Luminex antibody test Mild mild case mild cases multiple antigen multiple antigens Multiplexing neutralization neutralization test neutralizing antibody nucleocapsid nucleocapsid protein offer Pathogens RBD RDTs Receptor-binding domain Recombinant nucleocapsid protein respiratory SARS-CoV-2 SARS-CoV-2 spike sera serological serological test Serological tests Serosurveillance severe cases significantly lower specificity Support symptom onset target threshold titers virus neutralization assays virus neutralization test while [DOI] 10.1016/j.jviromet.2020.114025 PMC 바로가기 [Article Type] Article
Sensing of COVID-19 Antibodies in Seconds via Aerosol Jet Nanoprinted Reduced-Graphene-Oxide-Coated 3D Electrodes에어로졸 제트 나노프린트 환원 그래핀 산화물 코팅 3D 전극을 통해 몇 초 만에 COVID-19 항체 감지Article Published on 2021-02-012022-09-11 Journal: Advanced Materials (Deerfield Beach, Fla.) [Category] MERS, 진단, 치료기술, 치료법, [키워드] 3D printing 3D sensors aerosol antibody antibody tests antigens Biomarker Biomarkers Cell COVID-19 COVID-19 antibody Critical cross-react detect Diagnosis Diseases Ebola electrical electrochemical cell electrode gold Gold nanoparticles HIV impedance infectious agent infectious agents interleukin interleukin-6 introduced micropillars minute nucleocapsid Pandemics platform Protein Rapid RBD reduced Reduced graphene oxide reported S1 protein SARS-CoV-2 spike second sensor the antibody Treatment user interface Viral Viral antigen viral antigens Zika [DOI] 10.1002/adma.202006647 PMC 바로가기 [Article Type] Article
A novel screening strategy of anti-SARS-CoV-2 drugs via blocking interaction between Spike RBD and ACE2Spike RBD와 ACE2 간의 상호 작용 차단을 통한 항 SARS-CoV-2 약물의 새로운 스크리닝 전략Article Published on 2021-02-012022-08-31 Journal: Environment international [Category] MERS, SARS, 치료제, [키워드] ACE2 activity angiotensin angiotensin converting enzyme anti-SARS-CoV-2 Anti-SARS-CoV-2 drugs screening strategy binding binding energy blockade Blockade mechanism Compound compounds Corona drug drug design Drug screening druggability eight enzyme exhibited hACE2 hesperidin highest human angiotensin converting enzyme 2 information Interaction investigated mechanism overcome pandemic RBD Receptor binding domain required S RBD SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD screening strategy spike Spread Structure Structure-activity relationship structures therapy Virus Disease [DOI] 10.1016/j.envint.2020.106361 PMC 바로가기 [Article Type] Article
Development of multivalent nanobodies blocking SARS-CoV-2 infection by targeting RBD of spike proteinResearch Published on 2021-01-292022-10-29 Journal: Journal of Nanobiotechnology [Category] COVID-19, [키워드] ACE2 protein acquisition antibodies Antiviral antiviral activity antiviral property caused Consequences coronavirus SARS-CoV-2 COVID-19 demonstrated develop development effective exhibited global public health high affinity IMPROVE in vitro indicated Interaction naïve nanobodies nanobody Neutralizing neutralizing capacity outbreak pandemic Pseudotyped virus Pseudovirus neutralization RBD RBD domain resource Result Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 spike screened shown spike Spike protein therapeutic Treatment viruses [DOI] 10.1186/s12951-021-00768-w PMC 바로가기 [Article Type] Research
Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients코로나19 환자 모니터링을 위한 SARS-CoV-2 스파이크 단백질 유래 펩타이드에 대한 IgG 반응의 체계적인 평가Clinical Trial Published on 2021-01-222022-08-13 Journal: Cellular and Molecular Immunology [Category] SARS, 임상, 진단, 치료기술, [키워드] 12-mer peptide 95% CI a peptide microarray aa 1148–1159 aa 553–564 aa 577–588 aa 601–612 aa 625–636 Adaptive immunity analyzed antibody asymptomatic patient clinical centers Cohort collected combating Combination comparable Control Coverage COVID-19 cases COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients cross-reactivity Diagnosis diagnostic Diagnostic markers ELISA exhibited human coronavirus IgG IgG response independent other coronavirus other coronaviruses Patient peptide peptide microarray peptides reagent recombinant Recombinant spike protein S protein S1 protein S1–101 S1–105 S1–93 S1–97 S2–78 SARS-CoV-2 SARS-CoV-2 spike sensitivity sera serological serological test Serological tests several S protein-derived 12-mer peptides specificity spike Spike protein symptomatic and asymptomatic the S1 protein [DOI] 10.1038/s41423-020-00612-5 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaquesSARS-CoV-2는 붉은 털 원숭이에서 강력한 생식 중심 CD4 T 여포 도우미 세포 반응을 유도합니다Article Published on 2021-01-222022-09-10 Journal: Nature Communications [Category] 진단, 치료법, [키워드] Adaptive immunity Antibody Response Antibody responses Antiviral Blood CD4 Cell convalescent plasma COVID-19 follicular GC response GC responses generate Germinal center helper cell humoral induce induction Infectious diseases infused infusion lung lymph nodes Mild Monocytes Nucleocapsid proteins Peripheral blood plasma pro-inflammatory monocyte pro-inflammatory monocytes question receiving response rhesus rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serum IgG antibodies skewed stimulate Tfh Tfh cell Th1 the SARS-CoV-2 Viral viral infections Viral proteins [DOI] 10.1038/s41467-020-20642-x PMC 바로가기 [Article Type] Article
Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing ResponsesArticle Published on 2021-01-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antigenicity appear approach boost COVID-19 pandemic COVID-19 vaccine disease displaying dose ectodomain effective elicited ELISA geometric highlight immunization immunized mimicking morphology negative-stain electron microscopy neutralization neutralization titer Neutralizing activity neutralizing antibody newcastle disease virus Particle potent prefusion conformation prefusion-stabilized spike prime immunization response S-2P stabilization SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2-neutralizing antibody significantly higher spike Vaccine virus Virus-like particle virus-like particles VLP Week [DOI] 10.3390/vaccines9020073 PMC 바로가기 [Article Type] Article