sera – Page 47 – Communicable Diseases Research

Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease

Review

Published on 2021-08-172022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

SARS-CoV-2 Spike Pseudoviruses: A Useful Tool to Study Virus Entry and Address Emerging Neutralization Escape Phenotypes

Article

Published on 2021-08-162022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] address angiotensin-converting enzyme-2 antibody B.1.1.7 B.1.351 BSL-2 candidate vaccine Cell clinical trial convalescent COVID-19 develop disease effective escape expressing Genetic variant globe hACE2 help Lentiviral vector less MLV vector monoclonal antibody neutralization neutralization ability Neutralization assay Neutralizing antibodies NIBSC PBNA Phenotypes Prophylactic pseudovirus R 2 raising reagent recent receptor Research SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variants sensitivity sera severity South Africa spike susceptible time-consuming Transmissibility United Kingdom unmet need variants variants of concern virus VoC VOCs
[DOI] 10.3390/microorganisms9081744 PMC 바로가기 [Article Type] Article

Immunoglobulin G Immune Complexes May Contribute to Neutrophil Activation in the Course of Severe Coronavirus Disease 2019

면역 글로불린 G 면역 복합체는 심각한 코로나 바이러스 질병 2019 과정에서 호중구 활성화에 기여할 수 있습니다

Article

Published on 2021-08-162022-09-11
Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 바이오마커, 진단,

[키워드] acquisition activate acute respiratory syndrome analyzed antibody association Blood CCL2 CD11b CD32 CD66b coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 CXCL8 D-dimer dependent on Express IgG IgG antibodies IgG antibody immune immune complex Immune complexes Immunoglobulin Immunoglobulin G Inflammation Inflammatory Lactate lactate dehydrogenase macrophages mechanism Mild disease neutrophil Neutrophils overactive inflammatory response Patient patients with COVID-19 phenotype plasma concentration plasma concentrations Platelets Production proinflammatory promote respiratory SARS-CoV-2 sera severe coronavirus disease severe COVID-19 severe disease with mild disease worsening
[DOI] 10.1093/infdis/jiab174 PMC 바로가기 [Article Type] Article

Favorable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

자가면역 류마티스 질환이 있는 소아 및 청소년의 인간 코로나바이러스에 대한 유리한 항체 반응

Clinical and Translational Article

Published on 2021-08-142022-09-14
Journal: Med (New York, N.Y.) [Category] MERS, SARS, 임상, 진단,

[키워드] Abstract acute respiratory syndrome Adolescent Affect age antibodies antibody Antibody Response Arthritis Autoimmune Cancer Research UK children class-switching collected common-cold comparable Context coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 pandemic cross-reactive cure dermatomyositis determine difference elevated examined exhibited finding foundation Francis Crick funding HCoV-OC43 HCoV-OC43 spike healthy control human coronavirus Humoral immunity IgG IgG antibody immune immune dysfunction Immunoglobulin Immunosuppression Immunosuppressive treatment infect Infection Inflammatory juvenile idiopathic arthritis lack Lupus Medical Research Council MIS-C myositis NIHR nucleoprotein nucleoprotein of SARS-CoV-2 pandemic Patient patients prevalent raising receive response rheumatic disease Rheumatic diseases risk of COVID-19 SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 spike seasonal coronavirus sera severe symptom shielding Spike protein Street supported syndrome systemic lupus erythematosus the antibody response Treatment UCLH Wellcome Trust
[DOI] 10.1016/j.medj.2021.08.001 PMC 바로가기 [Article Type] Clinical and Translational Article

Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat spike protein RBD protects mice against COVID-19

Research Article

Published on 2021-08-122022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, SARS,

Plant-produced SARS-CoV-2 receptor binding domain (RBD) variants showed differential binding efficiency with anti-spike specific monoclonal antibodies

Research Article

Published on 2021-08-112022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

[키워드] ACE2 acute respiratory syndrome Anti-spike Beta binding binding affinity binding domain binding efficiency characterized contrary convalescent coronavirus disease Coronavirus-2 COVID-19 CR3022 death ELISA enzyme exhibited Host host cell receptor increase in mAb mAbs monoclonal antibody Mutation neutralization neutralizing antibody Nicotiana benthamiana other variants pandemic produced raise RBD RBD-Fc receptor reported required Respiratory illness responsible SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 RBD protein SARS-CoV-2 receptor sera severe pneumonia South Africa strain suggested the spike protein transient expression United Kingdom vaccinated individual variant
[DOI] 10.1371/journal.pone.0253574 PMC 바로가기 [Article Type] Research Article

Longitudinal analysis to characterize classes and subclasses of antibody responses to recombinant receptor-binding protein (RBD) of SARS-CoV-2 in COVID-19 patients in Thailand

태국의 COVID-19 환자에서 SARS-COV-2의 재조합 수용체-결합 단백질 (RBD)에 대한 항체 반응의 클래스 및 서브 클래스를 특성화하기위한 종단 분석

Research Article

Published on 2021-08-102022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, 치료제,

[키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme antibody Antibody assays Antibody Response Antibody responses contribute convalescent sera convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient COVID-19 patients Dengue fever detect domain ELISA ELISAs febrile healthy individual healthy individuals highest Host Human human immune response IgA IgG IgG level IgG levels IgG subclasse IgG subclasses IgG1 IgG3 IgM immune responses Infection Influenza Interpretation investigated leptospirosis longitudinal median molecular assays murine murine typhus natural infection ORF1ab ORF1ab gene outbreak Patient patients patients with COVID-19 Protein RBD RBD antigen reactivity respiratory RT-PCR SARS-CoV-2 SARS-COV-2 infection sera serological assays serum serum sample serum samples severe acute respiratory syndrome Coronavirus significantly higher Spike protein target tested Therapeutics tropical typhus Viral Viral detection viral spike protein
[DOI] 10.1371/journal.pone.0255796 PMC 바로가기 [Article Type] Research Article

Autoantibodies stabilize neutrophil extracellular traps in COVID-19

자가 항체는 COVID-19에서 호중구 세포외 트랩을 안정화합니다

Research Article

Published on 2021-08-092022-09-10
Journal: JCI Insight [Category] MERS, SARS, 진단, 치료제,

[키워드] Adaptive immunity antibodies antibody associations autoantibodies autoantibody Autoimmunity circulating clearance contribute correlation COVID-19 COVID-19 sera D-dimer Degradation degrade demonstrated determine Efficiency fraction function functional greater healthy control healthy controls Hospitalized IgG IgG and IgM IgM immunopathology impair individual inherent inverse correlation Level mechanical ventilation NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils oxygen oxygen supplementation Oxygenation Patient patients purified required sera serum severe COVID-19 Thromboinflammation variety with COVID-19
[DOI] 10.1172/jci.insight.150111 PMC 바로가기 [Article Type] Research Article

Effect of multiple freeze–thaw cycles on the detection of anti-SARS-CoV-2 IgG antibodies

항 SARS-CoV-2 IgG 항체 검출에 대한 다중 동결-해동 주기의 영향

Disease, Diagnosis and Diagnostics

Published on 2021-08-062022-09-10
Journal: Journal of Medical Microbiology [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Analysis anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibody antibodies Antibody detection average Coronavirus-2 COVID-19 detect detection Effect ELISA ELISA assay ELISA test except for freeze had no IgG IgG antibodies investigated Linear regression log no effect no significant difference nucleocapsid Participants positive random effect repeated replicate replicates respiratory RNA SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies sera serum Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significant difference slope statistical analysis tested thaw was performed
[DOI] 10.1099/jmm.0.001402 PMC 바로가기 [Article Type] Disease, Diagnosis and Diagnostics

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies

SARS-COV-2 스파이크 단백질에서의 시그니처 중화 항체로의 탈출

Research Article

Published on 2021-08-052022-08-13
Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 ACE2 binding ACE2 receptor Affect Alter Amino acid amino acid substitution amino acids Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody neutralization binding Cell changes in circulating Combination convalescent core COVID-19 Critical Determining develop diagnostics E484K elicited engage enzyme evade Evolution explanation grid Host host immunity hotspot identify Immune escape immune escape mutants immune evasion in silico increase Infection Interaction K417N lentivirus MONITOR Mutation mutations N501Y Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing-antibody Pandemics Protein provide provided pseudotyped lentiviruses Recognition reduce responses SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus SARS-CoV2 sera shown signature specificity Spike protein target targets tested the spike protein Therapies understanding vaccination Vaccine variants variants of concern Viral Viral protein virion virus
[DOI] 10.1371/journal.ppat.1009772 PMC 바로가기 [Article Type] Research Article