Preparing for future waves and pandemics: a global hospital survey on infection control measures and infection rates in COVID-19Short Report Published on 2021-12-202022-10-28 Journal: Antimicrobial Resistance and Infection Control [Category] COVID-19, [키워드] COVID-19 COVID-19 pandemic Health care worker hospital infection control infection rate measure Measures PPE Preparing reported supplementary material was performed [DOI] 10.1186/s13756-021-01029-z PMC 바로가기 [Article Type] Short Report
Long-acting injectable antipsychotic (LAI) prescribing trends during COVID-19 restrictions in Canada: a retrospective observational studyObservational Study Published on 2021-12-202022-10-27 Journal: BMC Psychiatry [Category] Coronavirus, COVID-19, SARS, [키워드] administer age Canada Care characterized collected concomitant medications COVID-19 COVID-19 pandemic decrease diabete disorder Equal examined Gender healthcare healthcare service Impact impacted incidence of COVID-19 individual Infection Long-acting injectable antipsychotics medication medications mental health service MONITOR National pandemic Patient Pharmacy prescribing Prescribing data psychotic disorders public health reduction remained Result retrospective Schizophrenia statistically significant study period supplementary material unique were used [DOI] 10.1186/s12888-021-03646-9 PMC 바로가기 [Article Type] Observational Study
A systematic review and meta-analysis of host genetic factors associated with influenza severityResearch Article Published on 2021-12-202022-10-28 Journal: BMC Genomics [Category] COVID-19, [키워드] 95% CI allele Analysis association disease Effect environmental factors Evidence explained Factor Genes Genetic Genetic polymorphism Genetic variant Genome-wide association study Host identify Influenza influenza infection Influenza severity Interaction investigated marker Meta-analysis Mild symptom opposite pathogen polymorphism populations Result retrieved severe respiratory failure severity stratified supplementary material susceptibility systematic review [DOI] 10.1186/s12864-021-08240-7 PMC 바로가기 [Article Type] Research Article
pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data scienceSoftware Published on 2021-12-202022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] Analysis automated Automated pipelines biological processe block Cavity characterization Cavity detection Computational methods Data analysis Data science Data structure detect drug design ecosystem facilitate homologous hydropathy Interaction mathematical modulate molecular dynamics NumPy occur Protein protocols Python Result SARS-CoV-2 SciPy Structure structures supplementary material Volume [DOI] 10.1186/s12859-021-04519-4 PMC 바로가기 [Article Type] Software
pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data scienceSoftware Published on 2021-12-202022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, [키워드] Analysis automated Automated pipelines biological processe block Cavity characterization Cavity detection Computational methods Data analysis Data science Data structure detect drug design ecosystem facilitate homologous hydropathy Interaction mathematical modulate molecular dynamics NumPy occur Protein protocols Python Result SARS-CoV-2 SciPy Structure structures supplementary material Volume [DOI] 10.1186/s12859-021-04519-4 PMC 바로가기 [Article Type] Software
Targeting CK2 mediated signaling to impair/tackle SARS-CoV-2 infection: a computational biology approachSARS-CoV-2 감염을 손상/퇴치하기 위한 CK2 매개 신호 표적화: 컴퓨터 생물학 접근Research Article Published on 2021-12-202022-09-10 Journal: Molecular Medicine [Category] SARS, 신약개발, 유전자 메커니즘, [키워드] Analysis antagonist antagonistic effect anticancer antiviral activity antiviral responses approach attenuation bind bleeding Cancer cancer treatment Cell CIGB-300 CK2 inhibitor Coagulation Combination computational analysis Computational biology coronavirus drug Drug repurposing early stage early stages Evidence evidence of Functional enrichment analyses Functional enrichment analysis HSBP1 human cells immune response incidence infected with SARS-CoV-2 inhibitor interfere Interference life cycle mechanism molecular molecular mechanism muscle NPM1/B23 peptide phenotype Phenotypes Phosphoproteomics Phosphorylation predict predicted provide provided recent respiratory respiratory disorders responsible Result RNA splicing SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle Signaling SQSTM1 SRSF1 supplementary material Support targeting the SARS-CoV-2 treat Viral viral infection viral infections virus Virus-host interaction Virus-host interactions was used [DOI] 10.1186/s10020-021-00424-x PMC 바로가기 [Article Type] Research Article
Long-acting injectable antipsychotic (LAI) prescribing trends during COVID-19 restrictions in Canada: a retrospective observational studyObservational Study Published on 2021-12-202022-10-04 Journal: BMC Psychiatry [Category] 신약개발, 임상, [키워드] administer age Canada Care characterized collected concomitant medications COVID-19 COVID-19 pandemic decrease diabete disorder Equal examined Gender healthcare healthcare service Impact impacted incidence of COVID-19 individual Infection Long-acting injectable antipsychotics medication medications mental health service MONITOR National pandemic Patient Pharmacy prescribing Prescribing data psychotic disorders public health reduction remained Result retrospective Schizophrenia statistically significant study period supplementary material unique were used [DOI] 10.1186/s12888-021-03646-9 PMC 바로가기 [Article Type] Observational Study
pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data sciencePykvfinder : 데이터 과학의 생체 분자 공동 탐지 및 특성을위한 효율적이고 통합 가능한 파이썬 패키지Software Published on 2021-12-202022-09-10 Journal: BMC Bioinformatics [Category] 치료기술, [키워드] Analysis automated Automated pipelines biological processe biological processes block blocks Cavity characterization Cavity detection Computational methods Data analysis Data science Data structure detect drug design ecosystem facilitate homologous hydropathy Interaction machine learning mathematical modulate molecular dynamics NumPy occur proof Protein protocols Python Result SARS-CoV-2 SciPy structural biology Structure structures supplementary material Volume [DOI] 10.1186/s12859-021-04519-4 PMC 바로가기 [Article Type] Software
Sex differences in the immune response to acute COVID-19 respiratory tract infectionResearch Published on 2021-12-202022-10-28 Journal: Biology of Sex Differences [Category] COVID-19, [키워드] acute COVID-19 Adaptive immune response age anti-inflammatory cytokine B cell blood sample circulating neutrophil Cohort cohorts collected conducted control group control patient COVID COVID-19 cytokine Cytometry demographics diagnosed with COVID-19 disease severity ELISA Ethnic groups female Female patients females Flow group Hospital admission hospitalized patient IL-10 IL-6 IL-8 immune response implicated increasingly infection rate inflammatory mediator Inflammatory response innate immune response leukocyte leukocytes male males MCP-1 mechanism men Mild MIP-1β moderate monocyte mortality rate Patient plasma pro-inflammatory cytokine respiratory tract infection response Result robust severe disease severity Sex difference significantly higher significantly increased significantly more supplementary material the disease three group were used [DOI] 10.1186/s13293-021-00410-2 PMC 바로가기 [Article Type] Research
Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcomeCOVID-19 환자 혈청의 비표적 대사체학은 심각성과 결과 모두의 잠재적인 예후 마커를 나타냅니다Original Article Published on 2021-12-202022-09-10 Journal: Metabolomics [Category] SARS, 바이오마커, 치료기술, [키워드] among others Analysis approach Bayesian Bayesian logistic regression model blind capture Cohort COVID-19 COVID-19 patient COVID-19 patient serum cross Deceased deoxycytidine diagnosis of COVID-19 discharged energy metabolism high resolution Hospital admission Host host inflammatory response host response include infected individual infected individuals Infection Kynurenine LC–MS/MS Orbitrap logistic regression model marker metabolism metabolite metabolites metabolomics Mild nucleic acid objective outcome Patient patient treatment Planning positive predict predicted Predictive predictor profile Prognostic marker property qualitative detection Result reveal ROC AUC ROC Curve selected serum severity statistical significance subset supplementary material Treatment UHPLC UHPLC-MS/MS uninfected control Untargeted metabolomics validation study Viral Viral load viral nucleic acid was performed [DOI] 10.1007/s11306-021-01859-3 PMC 바로가기 [Article Type] Original Article