Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoirearticle Published on 2013-06-152024-09-02 Journal: Nanoscale [Category] 대상포진, [키워드] cytotoxic T lymphocytes HIV Humoral immunity therapy vaccination viral latency [DOI] 10.1093/infdis/jit098 PMC 바로가기 [Article Type] article
Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway류마티스 관절염의 인간 유전학은 CD40 신호 전달 경로의 고처리량 약물 검사를 안내합니다Research Article Published on 2013-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated After allele Analysis approved drug Arthritis association Author B cells B lymphocyte B lymphocytes Biology can be used CD19+ CD40 CD40 ligand CD40 signaling Cell cell line chemical compounds clinical care coding Combination complex Compound consequence controls correlation counter deep sequencing develop disease drug Drug discovery drugs effort eQTL ExoN exonic explain expression finding Follow-up gain-of-function Genetic genetic findings Genome-wide association studies Genome-wide association study genotyping guide GWAS healthy control homozygous Human Human genetics identify implicated increase individuals Infection Inflammation inhibit inhibitor loci locus lymphocyte Lymphocytes mononuclear cell mononuclear cells mouse NF-kB NF-κB NF-κB signaling non-risk allele observé p65 pathway Patient Peripheral blood Peripheral blood mononuclear cells Phosphorylation Protein Quantitative RA RELA reporter retroviral Rheumatoid rheumatoid arthritis risk risk allele Screen second Sequencing seropositive Signaling single SNP small molecule Small molecules small-molecule screen subject subunit therapy trait traits transcription factor treat variant while [DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다Research Article Published on 2013-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 358Ala Abdominal aortic aneurysm affecting allele analyzed aortic aneurysm approach Arthritis Asp358Ala association Asthma Atrial fibrillation Author balance benefit Cambridge BioResource causal variant CD4+ T cell CD4+ T cells CHD Chronic diseases circulating cleavage clinical trial clinical trials common diseases complex complex diseases Concentration Control copy Coronary heart disease Critical cytokine diabete diabetes etiology Evidence expression functional Genetic genetic association Genetic variation heart disease human disease identify IL-6 IL-6 receptor IL-6 signaling IL-6R IL-6R signaling IL-6R signaling pathway IL6R Immune cell immune cells impairment implicated implication increase increase in independent Inflammatory Inflammatory responses influence interleukin interleukin-6 isoform mechanism membrane-bound molecular mechanism monocyte Monocytes mononuclear cell mononuclear cells Non-synonymous nucleotide Patient PBMCs Peripheral blood Peripheral blood mononuclear cells Phosphorylation polymorphism Population protein level protein levels RA reduce reduced reduction regulated Regulation rheumatoid arthritis risk rs2228145 Signaling sIL-6R single nucleotide Single nucleotide polymorphism soluble IL-6R Stat1 STAT3 Stimulation suggested surface expression surface receptor susceptibility T cells T1D therapeutic intervention therapy These data Transcription transcription factor transcription factors translate Treatment response Type 1 diabetes variant Variation Volunteer [DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article
Fourth European Conference on Infections in Leukaemia (ECIL-4): Guidelines for Diagnosis and Treatment of Human Respiratory Syncytial Virus, Parainfluenza Virus, Metapneumovirus, Rhinovirus, and CoronavirusReview Article Published on 2013-01-152022-10-31 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Coronavirus, [키워드] Adenovirus America appear Bone marrow transplantation Conference Diagnosis European Evidence Factor guideline hematopoietic HSCT HSCT patients Human IMPROVE Infection Infectious disease Influenza intrinsic knowledge leukemia Lower respiratory tract management morbidity and mortality outcome Patient Pneumonia radiological recommendation respiratory Respiratory failure respiratory virus risk Society Stem cell transplantation the patient therapy transplantation Treatment underlying disease virulence virus [DOI] 10.1093/cid/cis844 PMC 바로가기 [Article Type] Review Article
WAO Guideline for the Management of Hereditary AngioedemaArticle Published on 2012-12-152023-08-29 Journal: The World Allergy Organization Journal [Category] E형 간염, [키워드] Diagnosis guidelines HAE Hereditary angioedema International management medications therapy [DOI] 10.1097/WOX.0b013e318279affa PMC 바로가기
Human Monoclonal Antibodies against Highly Conserved HR1 and HR2 Domains of the SARS-CoV Spike Protein Are More Broadly NeutralizingResearch Article Published on 2012-11-212022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Amgen antibody binding conserved convalescent patient different ectodomain effective expressing glycoprotein Human Human monoclonal antibody immune implication Infected isolates monoclonal antibody neutralize Neutralizing Patient produced Pseudotyped virus Receptor binding domain Region respiratory S protein S1 domain S2 domain SARS-CoV SARS-CoV spike sequence sera severe shown Subunit vaccine the S protein therapeutic therapy Treatment variant viruses [DOI] 10.1371/journal.pone.0050366 PMC 바로가기 [Article Type] Research Article
Hepatitis B in pregnancyReview Published on 2012-09-142023-05-25 Journal: World journal of gastroenterology [Category] B형 간염, 핵심논문, [키워드] Breastfeeding Elective caesarean section entecavir Hepatitis B virus lamivudine Pregnancy telbivudine tenofovir therapy [DOI] 10.3748/wjg.v18.i34.4677 PMC 바로가기 [Article Type] Review
Therapy of uncomplicated falciparum malaria in Europe: MALTHER – a prospective observational multicentre study유럽에서의 단순한 팔시파룸 말라리아 치료: MALTHER – 전향적 관찰 다기관 연구Research Published on 2012-06-222024-08-14 Journal: Malaria Journal [Category] 말라리아, [키워드] adverse events Europe Fever clearance time Imported falciparum malaria Parasite clearance time therapy Treatment change Uncomplicated [DOI] 10.1186/1475-2875-11-212 PMC 바로가기 [Article Type] Research
Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection작은 분자에 의한 숙주 면역 방어의 자극은 세균 감염으로부터 C. elegans를 보호합니다Research Article Published on 2012-06-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Analysis antibiotic Antibiotics ATF-7 Author Bacterial Bacterial infection Bacterial infections bacterial pathogen Bacterial pathogens Caenorhabditis elegan Caenorhabditis elegans cellular processe cellular processes Compound conserved effector molecule Efficacy elegan expression Gene Genes growth Host immune response host immunity identify immune immune regulators immunostimulatory Infection Interaction low molecular weight mechanism mechanism of action mode molecule molecules mutants nematode offer Pathogens pathway promote PROTECT Pseudomonas aeruginosa required small molecule Small molecules stimulate Stimulation tested therapy These data Transcription transcription factor Transcriptome Treatment variety [DOI] 10.1371/journal.pgen.1002733 PMC 바로가기 [Article Type] Research Article
Optimization of adefovir therapy in chronic hepatitis B according to baseline predictors and on-treatment HBV DNA: a 5-Year prospective studyResearch Published on 2011-09-212023-06-02 Journal: Virology Journal [Category] B형 간염, [키워드] adefovir dipivoxil chronic hepatitis B Hepatitis B virus hepatitis Be antigen positive predictor therapy [DOI] 10.1186/1743-422X-8-444 PMC 바로가기 [Article Type] Research