Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron Research Published on 2022-01-212022-10-05 Journal: Nature [Category] SARS, 변종, [키워드] ameliorated B.1.1.529 B.1.1.7 B.1.617.2 Beta Caco2 cells Calu3 cause Delta explain inefficient Infection K18-hACE2 mice Lower respiratory tract lowest Lung pathology mice mortality rate neutralization omicron other variants pathogenicity reduced replication reduction in Replication resulting SARS-CoV-2 therapeutic TMPRSS2 transmembrane serine protease variant variant of SARS-CoV-2 variants virus wild-type SARS-CoV-2 wild-type strain [DOI] 10.1038/s41586-022-04442-5 [Article Type] Research
Delayed Antiviral Immune Responses in Severe Acute Respiratory Syndrome Coronavirus Infected Pregnant MiceMicrobiology Published on 2022-01-212022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE2 Activation acute respiratory syndrome antibody antibody production Antibody titers cause CD8 coronavirus coronavirus disease correlated Course COVID-19 Delayed elevated examined expression Fertility IgM immune response immune responses in viral Infection interfere lung marker mice Mortality non-pregnant female occur Post-infection Pregnancy pregnant Proinflammatory cytokine proinflammatory cytokines remained reported respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2-specific IgG serum Symptom T cell T cell activation the disease the SARS-CoV-2 virus Transgenic mouse Transmission Viral load viral loads were infected [DOI] 10.3389/fmicb.2021.806902 PMC 바로가기 [Article Type] Microbiology
Evidence for a semisolid phase state of aerosols and droplets relevant to the airborne and surface survival of pathogens417 Published on 2022-01-212022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, SARS, [키워드] aerosol aerosol-phase state Aerosols amorphous phases can be used cause change changes in composed Compound condition conditions dependent on diffusion disease transmission droplet droplets Efflorescence Evidence expected growth media help heterogeneity highlight Host identify inactivation Infectious disease inhibited Laboratory mechanism mitigate observation Particle pathogen Pathogens Previous studies PROTECT Protein public health reaction recommendations released respiratory aerosol respiratory tract SARS-CoV-2 Significance solutes Spread suppressed survival unlikely viability viral survival virus viruses [DOI] 10.1073/pnas.2109750119 PMC 바로가기 [Article Type] 417
SARS-CoV-2 Remains Infectious on Refrigerated Deli Food, Meats, and Fresh Produce for up to 21 DaysArticle Published on 2022-01-212022-11-01 Journal: Foods [Category] COVID-19, [키워드] antiviral effects cause Cooking COVID-19 Day determine exhibited fat food food contamination food handling foodborne transmission Fresh highlighting inactivated infect Infection Infectious virus ingestion intestinal cells medium occur pathogen PCR-based assay Plaque assay processed Produce Protein qRT-PCR remained risk of infection SARS-CoV-2 source of infection Support survival thermal processing Viral RNA virus [DOI] 10.3390/foods11030286 PMC 바로가기 [Article Type] Article
Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study관찰 중개 연구에서 중환자 COVID-19 환자의 전신 염증 및 결과에 대한 IFIH1 rs1990760 변이체의 효과Research Article Published on 2022-01-212022-09-10 Journal: eLife [Category] 변종, [키워드] 95% CI 95% confidence interval analyzed Anti-inflammatory anti-inflammatory phenotype applied benefit Blood cause Cell changes in clinical trial clinical trials coding Cohort Concentration Corticosteroid corticosteroid treatment Corticosteroids COVID COVID-19 COVID-19 patient COVID-19 patients Critically ill death determine Dexamethasone discharge distribution drug Effect ENCODE experiment expression Factor funding Gene Expression greater hazard ratio healthy volunteer healthy volunteers help hospital host response Human ICU IFIH1 IL-6 IL6 immune Immune cell immune cells immune system Impact in-silico increase in individual Infection Inflammation Inflammatory response intensive care intensive care unit Laboratory less lower expression Lung injury MDA5 mechanical ventilation mediators moderate to severe modulate mononuclear cell mononuclear cells Mortality outcome outcomes Pathways Patient patients patients with moderate peripheral Peripheral blood Peripheral blood mononuclear cells pharmacogenomics physician populations pro-inflammatory mediators prospectively studied Protein recognize Red reduce regulate respond risk RNA serum Serum IL-6 severe COVID-19 Spain steroid Steroids supported survived systemic inflammation team the patient translational treat treated Treatment triggered variant variants Variation Viral viral infections virus viruses were measured [DOI] 10.7554/eLife.73012 PMC 바로가기 [Article Type] Research Article
Perception and Challenges of Preventive Measures of COVID-19 Among Nepalese Frontline Health Professionals: An Unexplored RealismPublic Health Published on 2022-01-202022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] age anticipated assistant calculated Care cause challenge COVID-19 COVID-19 transmission Critical cross-sectional disease Epidemic equipment Google form hcp Health health care personnel (HCP) health worker healthcare personnel healthcare worker information knowledge measure Myths national guidelines New coronavirus outlined participant participated Perception Personal protective equipment (PPE) Perspective Policy problem questionnaire realism Research Respiratory illness Result Support was used [DOI] 10.3389/fpubh.2021.747070 PMC 바로가기 [Article Type] Public Health
Antibody Responses to BNT162b2 Vaccination in Japan: Monitoring Vaccine Efficacy by Measuring IgG Antibodies against the Receptor-Binding Domain of SARS-CoV-2Research Article Published on 2022-01-192022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), SARS, [키워드] acute respiratory syndrome age analyzed antibody antibody isotype antibody production Antibody Response BNT162b2 BNT162b2 vaccine cause clinical setting Cohort coronavirus coronavirus disease correlated correlation COVID-19 detect determine dose Efficacy enzyme enzyme-linked immunosorbent Factors female Gender high correlation hypertension IgA IgG IgG level IgM immunoassay individual individuals information Japan Japanese Laboratory levels of antibodies males mass vaccination MONITOR monitoring mRNA vaccine negative correlation Neutralizing activity of BNT162b2 powerful tool predict provide RBD reported response SARS-CoV-2 SARS-CoV-2 vaccination second dose second vaccination sera Serological assay significantly significantly higher the receptor-binding domain vaccinated individual vaccination Vaccination strategy Vaccine was measured were measured [DOI] 10.1128/spectrum.01181-21 PMC 바로가기 [Article Type] Research Article
Dissemination and Implementation of a Google Apple Exposure Notification System for COVID-19 Risk Mitigation at a National Public University: Protocol for a Pilot Evaluation Study in a Real-World SettingProtocol Published on 2022-01-192022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] acceptability acceptance addition adoption agency Apple approach belief cause Clemson University communication Contact tracing COVID-19 COVID-19 mitigation COVID-19 testing COVID-19 transmission Data collection determine develop dissemination element evaluate expected exposure exposure notification system facilitator for inclusion Google group help Identifier identify implementation Implementation science include Isolation Local maintenance mitigate Mitigation mobile phone technology Model National notification objective outbreak outcome pandemic protocol Public public health quarantine recommendation reduce report Result risk SARS-CoV-2 setting South Spread Strategy Support System technology the United State Transmission university university setting Usage virus was used [DOI] 10.2196/32567 PMC 바로가기 [Article Type] Protocol
The effects of the COVID-19 pandemic on the use of the performance-enhancing drugsCOVID-19 전염병이 경기력 향상 약물 사용에 미치는 영향Article Published on 2022-01-192022-09-11 Journal: Acta bio-medica : Atenei Parmensis [Category] SARS, 치료기술, [키워드] activities activity addition addressed adopted adulteration adverse effect adverse effects Affect affected affecting anabolic Analysis androgenic steroid approach athletic Awareness blood sample business cause charge children closure Committee competing complex Compliance concerning Consumption Contamination Control coronavirus disease COVD-19 COVID-19 COVID-19 pandemic criteria damages Dilution doping Doping in sport driver driving drug Drug Abuse drugs Early detection Effect effort ENhance event events exacerbated forensic science foundation Government greater harmful substance Health Health Committee health protection impacted IMPROVE include increased risk information integrity introduced involved Italian Italy Laboratory lack list lockdown lockdowns measure methodology Modification MONITOR narcotic not limited NPs organization pandemic Patient phenomenon popularity positive Prescriptions Prevalence professional sports PROTECT protection provided public health raise raised raising Research revision risk rule Rule of law scaled Section similarity social distancing sports Spread Steroids Stress substance substance abuse Substance use Substance use disorder substance use disorders Substitution supervision suspicion tested the disease threat Threats Tokyo Transposition triggered Urine WADA World Anti-doping Agency [DOI] 10.23750/abm.v92i6.12377 PMC 바로가기 [Article Type] Article
Immunodominant and Neutralizing Linear B-Cell Epitopes Spanning the Spike and Membrane Proteins of Porcine Epidemic Diarrhea VirusImmunology Published on 2022-01-192022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] amino acid sequence B-cell epitope cause Complete consensus sequence contribute demonstrated disease ELISA testing epidemic diarrhea epitope Epitope prediction genetic diversity greater group high mortality rate identify immune stimulation immunodominant epitope immunoinformatics insight linear linear B-cell epitope M protein membrane membrane protein NCBI database neutralization Neutralizing neutralizing epitope nine offer PEDV peptide peptide-based immunoassays Porcine epidemic diarrhea virus predicted profile Protein Proteins provided retrieved S2 subunit sera Seven Spike protein strain Strains the S protein the Spike Vaccine virus Virus neutralization [DOI] 10.3389/fimmu.2021.785293 PMC 바로가기 [Article Type] Immunology