Dexamethasone – Page 48 – Communicable Diseases Research

Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2

Research Article

Published on 2021-01-072022-10-27
Journal: BMC Medical Informatics and Decision Making [Category] Coronavirus, COVID-19,

Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2

SARS-CoV-2에 대한 숙주 세포의 전사 반응을 기반으로 COVID-19에 대한 약물 용도 변경을 위한 전산 분석

Research Article

Published on 2021-01-072022-09-10
Journal: BMC Medical Informatics and Decision Making [Category] 신약개발, 유전자 메커니즘, 치료제,

[키워드] activated addition affected Analysis approach caused clinical trials coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 treatment Critical CXCR6 Data analysis death rate Dexamethasone drug drug-target effective effective drug effective drugs epithelial cell epithelial cells ERK evaluated facilitate Gene Expression high mortality rate host cell host cells human lung human lung epithelial cells identify immune Infection Integrative analysis involved IRF7 Jak-STAT JNK life cycle MAPK molecular MYD88 NFkB Ontology pandemic pathway Pathways receiving reduce reported Repurposed drug Repurposed drugs resources respiratory Respiratory Support Result SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling signaling pathway signaling pathways significantly STAT therapy transcriptional response Treatment treatments for COVID-19 Vaccine
[DOI] 10.1186/s12911-020-01373-x PMC 바로가기 [Article Type] Research Article

Randomised controlled trials for COVID-19: evaluation of optimal randomisation methodologies-need for data validation of the completed trials and to improve ongoing and future randomised trial designs

COVID-19에 대한 무작위 대조 시험: 최적의 무작위화 방법론 평가 - 완료된 시험의 데이터 검증 및 진행 중인 및 미래의 무작위 시험 설계 개선 필요

Review

Published on 2021-01-012022-09-11
Journal: International journal of antimicrobial agents [Category] 임상,

[키워드] (coronavirus disease 2019 benefit Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 Dexamethasone disease severity group Guidance HCQ Health Organization high mortality hospitalised COVID-19 patient Hydroxychloroquine IMPROVE Lopinavir Lopinavir/ritonavir methodology Metrics Mortality NIH Ordinal Scale outcomes pandemic patients randomisation randomised controlled trial Randomised trial RCT RCTs recovery RECOVERY trial reduced Remdesivir risk reduction Ritonavir sampling errors seven-point ordinal scale severity solidarity the disease Time to recovery treat Treatment Trial trials utilised WHO World Health Organization
[DOI] 10.1016/j.ijantimicag.2020.106222 PMC 바로가기 [Article Type] Review

Design and Rationale of a Randomized, Double-Blind, Placebo-Controlled, Phase 2/3 Study Evaluating Dociparstat in Acute Lung Injury Associated with Severe COVID-19

Clinical Trial

Published on 2021-01-012022-10-05
Journal: Advances in therapy [Category] SARS, 임상,

[키워드] acute lung injury added advance anti-inflammatory properties approach Biomarker bleeding cause caused coagulation disorder Cohort contributed COVID-19 Critical care D-dimer determine Dexamethasone Dociparstat double-blind Efficacy Emergency use endpoints enrolled Evaluating Extracellular global pandemic HMGB1 hospital hospital ward Hospitalized hypercoagulable Hyperinflammatory Hypoxemia IL-6 Infection lung mechanical ventilation morbidity and mortality NETs Neutrophil extracellular traps New NIAID Novel coronavirus P-selectin participant pathology Patient patients patients with COVID-19 performed phase Phase 2 phase 2/3 trial Phase 3 Placebo placebo-controlled platelet factor 4 Platelet factor 4. positive primary endpoint proportion Randomized rationale reduced risk Respiratory failure robust SARS-CoV-2 sodium Standard of care subsequent supplemental oxygen treat with COVID-19
[DOI] 10.1007/s12325-020-01539-z PMC 바로가기 [Article Type] Clinical Trial

Combined Use of Tocilizumab and Mesenchymal Stromal Cells in the Treatment of Severe Covid-19: Case Report

중증 코비드-19 치료에 토실리주맙과 중간엽 기질 세포의 병용: 증례 보고

Case Reports

Published on 2021-01-012022-09-12
Journal: Cell transplantation [Category] 진단,

COVID-19 Post-Infectious Encephalitis Presenting With Delirium as an Initial Manifestation

섬망을 초기 징후로 나타내는 COVID-19 감염 후 뇌염

Case Reports

Published on 2021-01-012022-09-11
Journal: Journal of investigative medicine high impact case [Category] 치료기술,

[키워드] abnormal behavior Abnormalities acute respiratory syndrome autoantibody cerebrospinal fluid coronavirus coronavirus disease COVID-19 COVID-19 pneumonia delirium Dexamethasone discharge elevated Encephalitis Fever Immunoglobulin immunoglobulin therapy immunosuppressive immunosuppressive therapy infectious encephalitis inflammatory change initial initial symptom Intravenous immunoglobulin intravenous methylprednisolone magnetic resonance imaging manifestation Methylprednisolone neuronal Older Older adults Patient pleocytosis post-infectious encephalitis. protein concentration respiratory respiratory symptoms RNA SARS-CoV-2 Severe acute respiratory syndrome Severe COVID-19 pneumonia surface protein the patient therapy Tocilizumab with COVID-19
[DOI] 10.1177/23247096211029787 PMC 바로가기 [Article Type] Case Reports

Use of dexamethasone, remdesivir, convalescent plasma and prone positioning in the treatment of severe COVID-19 infection in pregnancy: A case report

Case report

Published on 2021-01-012022-10-05
Journal: Case Reports in Women's Health [Category] 치료법,

Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing Study

SARS-CoV-2 주요 프로테아제 표적화: 컴퓨터 약물 용도 변경 연구

Article

Published on 2021-01-012022-08-31
Journal: Archives of medical research [Category] SARS, 신약개발, 치료제,

[키워드] 6LU7 acute respiratory syndrome acute respiratory syndrome coronavirus-2 approach approved approved drug aprepitant arbutin barnidipine clinically coronavirus disease COVID-19 Dexamethasone docked docking docking score docking scores docking tool drug Drug discovery Drug repurposing drug-target DrugBank drugs electrostatic interactions exploration Favipiravir FIVE hydrophilic hydrophobic in silico in viral inhibit Ligand limitation M pro M(pro) management molecular molecular dynamics molecular dynamics simulations molecular interaction novel Novel coronavirus novel coronavirus disease pandemic protease Protein Remdesivir Replication reported repurposing researcher respiratory SARS-CoV-2 Schrodinger Severe acute respiratory syndrome Standard Structure targeting targets terbutaline tipiracil Treatment US-FDA Vaccine development Viral viral replication Virtual screening
[DOI] 10.1016/j.arcmed.2020.09.013 PMC 바로가기 [Article Type] Article

Successful Treatment of Elderly Male With COVID-19 Infection With Severe Acute Respiratory Distress Syndrome Using Multimodal Therapy, Including Immune Modulation Therapy

Infectious Disease

Published on 2020-12-312022-10-31
Journal: Cureus [Category] COVID-19,

Background to new treatments for COVID‐19, including its chronicity, through altering elements of the cytokine storm

Review

Published on 2020-12-242023-06-16
Journal: Reviews in Medical Virology [Category] MERS,

[키워드] anti‐TNF biologicals COVID‐19 treatment Dexamethasone IL‐7
[DOI] 10.1002/rmv.2210 PMC 바로가기 [Article Type] Review