Differences in the tissue tropism to chicken oviduct epithelial cells between avian coronavirus IBV strains QX and B1648 are not related to the sialic acid binding properties of their spike proteinsResearch Published on 2014-06-142022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] analysed Asia avian coronavirus binding Cell characteristic Complete Culture difference disorders Efficiency epithelial cell epithelial cells Europe Genotype IBV infect Infection Infectious Bronchitis Virus kidney Kidney disease Occurrence organs oviduct pathogen pathogenicity permanent cell problem question reason reproductive S1 protein serotypes sialic acid Spike protein strain Strains sugar susceptibility the disease tissue tropism vaccination viruses [DOI] 10.1186/1297-9716-45-67 PMC 바로가기 [Article Type] Research
Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa인간 아연 수송체 ZIP4(SLC39A4)의 극단적인 인구 차이는 사하라 사막 이남의 아프리카에서 양성 선택으로 설명됩니다Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accompanied acrodermatitis acrodermatitis enteropathica African allele allele frequencies allele frequency Amino acid Author biological function Cell characterized classical computer simulations Concentration deficiency derived allele difference different directional disease phenotype disease risk DNA Evidence explained expression extreme finding fixation found functional Genetic Health HeLa cells homeostasis hotspot Human human population human populations implication intestinal investigated isoform leucine Local locus membrane Mutation natural selection Neanderthal Non-synonymous overexpression pathogen Pathogens polymorphism Population positive Positive selection Protein Recombination reduced reducing regulated Regulation Research Selection selective sweep significantly SLC39A4 sub-Saharan Africa surface protein Trace element transporter valine variant West Zinc zinc deficiency [DOI] 10.1371/journal.pgen.1004128 PMC 바로가기 [Article Type] Research Article
Sialic Acid Binding Properties of Soluble Coronavirus Spike (S1) Proteins: Differences between Infectious Bronchitis Virus and Transmissible Gastroenteritis VirusArticle Published on 2013-07-262022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] acid aminopeptidase N APN binding binding ability binding activity Cell cells compared coronavirus coronavirus coronavirus spike proteins detectable difference different experiment gastroenteritis had no host cell IBV IgG Infection Infectious Bronchitis Virus Interaction property receptor sialic acid sialic acid receptor spike Spike protein TGEV the spike protein Viral proteins virus [DOI] 10.3390/v5081924 PMC 바로가기 [Article Type] Article