immune responses – Page 48 – Communicable Diseases Research

SARS-CoV-2 Variants of Concern

우려의 SARS-CoV-2 변종

Review

Published on 2021-11-012022-09-11
Journal: Yonsei medical journal [Category] SARS, 변종,

Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy

항-CD20 요법을 받는 다발성 경화증 환자의 SARS-CoV-2 백신에 대한 체액 및 T 세포 면역 반응 불일치

Article

Published on 2021-11-012022-09-11
Journal: EBioMedicine [Category] MERS, SARS, 진단, 치료기술,

[키워드] anti-CD20 anti-CD20 therapy array CD20 Cell Community COVID COVID-19 COVID-19 infection determine disease Donor donors generosity Genscript glycoprotein humoral Humoral immunity humoral immunity, multiple sclerosis, anti-CD20 therapies. Humoral response humoral responses IFN-γ IgG immune response immune responses immunoassay impair increase in incubated individual interferon gamma Johns Hopkins Johns Hopkins University linear models Mabtech Medicine mRNA vaccines multiple sclerosis participant PBMC PBMCs peptide peptides Plate receptor reduced Research robust SARS-CoV-2 SARS-CoV-2 vaccination School serum SFC Society Spectrum sphingosine sphingosine-1-phosphate spike glycoprotein subset supported T cell T cell response T cell responses T cells tested Therapies therapy translate
[DOI] 10.1016/j.ebiom.2021.103636 PMC 바로가기 [Article Type] Article

Therapeutic approaches for SARS-CoV-2 infection

SARS-CoV-2 감염에 대한 치료적 접근

Review

Published on 2021-11-012022-09-11
Journal: Methods (San Diego, Calif.) [Category] 신약개발, 치료제,

Antibody responses after documented COVID-19 disease in patients with autoimmune rheumatic disease

자가면역 류마티스 질환 환자에서 기록된 COVID-19 질병 후 항체 반응

Article

Published on 2021-11-012022-09-11
Journal: Clinical Rheumatology [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] age anti-N IgG anti-S IgG anti-spike protein IgG antibody Antibody Response Antibody titers Arthritis Autoimmune Autoimmune disease Clinical characteristics Cohort Comorbidities consecutive patient Control controls COVID-19 COVID-19 disease COVID-19 susceptibility days post infection days post-infection detectable Diagnosis disease drug drugs fasciitis females FIVE Health humoral immune response IgG immune dysfunction immune response immune responses Immunosuppressant immunosuppressants less median moderate not differ Patient Point positive proportion protective antibodies Protective antibody protective antibody response Protein rheumatic disease Rheumatic diseases rheumatoid arthritis robust Seven severe COVID-19 severity of COVID-19 Sex spondyloarthritis the antibody
[DOI] 10.1007/s10067-021-05801-9 PMC 바로가기 [Article Type] Article

Perforin, COVID-19 and a possible pathogenic auto-inflammatory feedback loop

퍼포린, COVID-19 및 가능한 병원성 자가염증 피드백 루프

Review

Published on 2021-11-012022-09-11
Journal: Scandinavian journal of immunology [Category] SARS, 유전자 메커니즘,

[키워드] addition association auto‐inflammatory Cell COVID COVID-19 COVID-19 infection cytokine Cytokine storm Cytokines cytotoxic T lymphocyte cytotoxic T lymphocytes cytotoxicity downregulation dysregulation epidemiological Evidence excess expression haemophagocytic lymphohistiocytosis host cells IL-6 IL-6 expression immune response immune responses increase interleukin‐6 Killer cell mechanism microbial infection monocytosis natural killer natural killer cell NK cell NK cells overproduction pathogenic perforin promote raised reduced reduction in scar severe COVID-19 synergistic therapy Thrombus thrombus formation turn viral clearance
[DOI] 10.1111/sji.13102 PMC 바로가기 [Article Type] Review

Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigen

전혈 전사 반응의 뚜렷한 패턴은 동일한 항원을 암호화하는 아데노 바이러스 및 poxviral 벡터 백신으로 예방 접종 후 마우스에서 유도된다.

Research

Published on 2021-10-302022-09-10
Journal: BMC Genomics [Category] MERS, SARS, 유전자 메커니즘,

[키워드] adaptive immune responses Adenovirus Administered Analysis Antigen antigens cell activation cellular ChAdOx1 change changes characterisation Combination combinations Comparative analysis COVID-19 vaccine Diseases effective Emerging infectious diseases Epigenetic evaluate Express expression Gene Expression gene signature Genes greater heterologous prime-boost human clinical trial human clinical trials humoral immune response immune responses Infectious diseases innate immune involved Killer cell leads magnitude mechanism MHC class I mice natural killer natural killer cell Pathogens pathway Protective protective response protective responses Rapid induction regimen Regulation response Result significant enrichment single dose supplementary material T cell These data TLR2 transcriptional transcriptional response transgene type I interferon type I interferon genes Vaccine vaccine construct vaccine platform valuable resource vector vectors Viral Viral vector vaccine was used Whole blood
[DOI] 10.1186/s12864-021-08061-8 PMC 바로가기 [Article Type] Research

Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host

임상 관행은 COVID-19 환자의 호흡기 미생물군유전체 구성 및 숙주와의 상호작용의 기초가 됩니다

Article

Published on 2021-10-292022-09-10
Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법,

[키워드] antibiotic association Bacteria changes in clinical clinical microbiology Community condition confounder confounders contribute contributing to Control COVID-19 COVID-19 patient COVID-19 patients Disease progression driving Evidence exacerbated explain Host ICU identify immune cells immune response immune responses Infection inflammatory markers inflammatory phenotype intensive care intensive care unit Interaction Lower respiratory tract Lungs mechanical ventilation Microbiome microbiome composition microbiota oxygen oxygen support pathology physical physically proinflammatory reduced Research respiratory respiratory tract SARS-CoV-2 viral load Sequencing severe COVID-19 patients severe disease Single-cell transcriptomics Treatment underlie understanding upper respiratory tract Variation Viral Viral load with COVID-19
[DOI] 10.1038/s41467-021-26500-8 PMC 바로가기 [Article Type] Article

Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine

Research Article

Published on 2021-10-292022-10-28
Journal: Science Advances [Category] COVID-19,

Ezrin Peptide Therapy from HIV to COVID: Inhibition of Inflammation and Amplification of Adaptive Anti-Viral Immunity

HIV에서 COVID로의 Ezrin Peptide Therapy: 염증 억제 및 적응형 항바이러스 면역의 증폭

Review

Published on 2021-10-282022-09-10
Journal: International Journal of Molecular Sciences [Category] 치료제,

[키워드] accompanied activate adaptive adjuvant adjuvants Administered amino acids Anti-viral immunity antibody antibody titres B cell candidiasis chronic diarrhea Clinical studies clinical study Colon COVID Cytokines derivative diarrhea disappearance disease domain duodenum dysregulation effective ENhance enhancer enhancers Enterocolitis expression ezrin ezrin peptides FIVE gp120 HCV herpes herpes zoster HIV HIV-infected patients homologous HPV Human human respiratory viruses IL-6 immune responses Immunity Inflammation inflammatory complications Inflammatory cytokines Influenza Inhaled inhibition inhibitor inhibitors innate immune response innate immune responses mice Microbiome middle Mild-to-moderate mucosal Mutation normalization opportunistic infection opportunistic Infections outbreak peptide peptides Placebo Prevent produced Protein randomised receptor Registered replicated respiratory respiratory viruses resulting Russia SARS-CoV-2 SARS-COV-2 infection shown stomach synthetic synthetic peptides T cell therapy tissue repair treat Treatment ulceration vaccination Viral viral respiratory virus virus infection viruses Volunteer
[DOI] 10.3390/ijms222111688 PMC 바로가기 [Article Type] Review

Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines

Review Article

Published on 2021-10-282022-10-04
Journal: NPJ Vaccines [Category] 치료제,