A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease게놈 규모의 RNA-간섭 스크린은 헌팅턴병의 병리학적 특징으로 RRAS 신호를 식별합니다Research Article Published on 2012-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition Amino acid amino-terminus Analysis Author cascade caused Cell cellular cellular processe cellular processes component disease disorder Drosophila dysfunction effective ENCODE enzyme excitotoxicity farnesyltransferase FNTA found functional Glutamate Glutamine huntingtin Huntington's disease identify implicated in addition to increase in inhibitor Interaction Intervention involved Localization loss-of-function mammalian mechanism mechanisms mitochondrial mitochondrial dysfunction motor dysfunction mouse model mutant Mutation observé occur pathogenic pathway Pathways pharmacological PIN1 PLK1 Protein proteolysis RAF1 reduce reduced reducing repeated RNA interference RRAS Screen Signaling signaling pathway small molecule solubility suppress suppressed suppressor Therapeutic benefit These data Toxicity was performed [DOI] 10.1371/journal.pgen.1003042 PMC 바로가기 [Article Type] Research Article
A Single Polar Residue and Distinct Membrane Topologies Impact the Function of the Infectious Bronchitis Coronavirus E ProteinResearch Article Published on 2012-05-032022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activities adopted affected Antiviral strategies Author coronavirus correlated defined different disrupt disrupting domain E protein examined found function functions Golgi Host hydrophobic IBV identify Impact implicated in vitro independent infected cells Infection infectious Infectious Bronchitis Virus Infectious virus less mapped mechanism of action membrane membrane protein mutant occur Particle Particles predicted promote Protein reported required residue secretory pathway Substitution thought Topology transmembrane virion assembly virus [DOI] 10.1371/journal.ppat.1002674 PMC 바로가기 [Article Type] Research Article
A Genome-Wide Association Scan on the Levels of Markers of Inflammation in Sardinians Reveals Associations That Underpin Its Complex Regulation사르데냐인의 염증 표지자 수준에 대한 게놈 전체의 연관성 스캔은 복잡한 조절을 뒷받침하는 연관성을 보여줍니다Research Article Published on 2012-01-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ABO gene AIRE APOC-I approach association associations Author autosomal C-reactive protein CADM3 CCR2 Cohort common disease complex conducted CR1 CRP CRP gene damaged cells DARC detect different different diseases Effects erythrocyte sedimentation erythrocyte sedimentation rate ESR Evidence Factor found functional Gene genetic determinant genetic determinants Genetic variant genetic variants genome-wide association scan Genome-wide association scans genome-wide significant genotyped GWAS HBB Health help High-sensitivity C-reactive protein highlight HNF1A hsCRP ICOSLG identifying IL-6 IL-6R gene ImmunoChip implicated IMPROVE included independent individual individuals Inflammation inflammation erythrocyte sedimentation rate Inflammatory biomarker interleukin interleukin-6 knowledge large cohort led to Level loci MCP-1 mechanism MetaboChip custom arrays molecular mechanism molecular mechanisms monocyte monocyte chemotactic protein-1 novel organism performed power pro-inflammatory molecule pro-inflammatory molecules Protective Protein provided QTLs Quantitative quantitative traits receptor Regulation replicated robust rs113459440 rs11829037 rs1205 rs12075 rs12567990 rs17141006 rs225918 rs3026968 rs3093077 rs3845624 rs4129267 rs4420638 rs4910472 rs657152 Sardinia Sardinian sedimentation rate selected SNP SPPL3 TMEM57 UCN119B UNC119B variant X chromosome SNP [DOI] 10.1371/journal.pgen.1002480 PMC 바로가기 [Article Type] Research Article
Comparative and Functional Genomics of Rhodococcus opacus PD630 for Biofuels Development바이오연료 개발을 위한 Rhodococcus opacus PD630의 비교 및 기능 유전체학Research Article Published on 2011-09-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accurate Actinomycetale Analysis approach assigned Author Bacteria bacterium Biofuel carbon catabolic cellular Comparative Comparative analysis Complete compounds conserved development dry weight Engineering Enzymes eukaryotic Fatty acid fatty acids Gene gene family Genetic Genome genome sequence Genomics growth homologous homologous genes identify implicated included information led to lipid metabolism metabolic product metabolism multidisciplinary approach Pathways performed phenotypic phenotypic information Phylogenetic analysis predicted gene provide provided reaction related Research screened sequenced substrate substrates Support target gene Target genes triacylglycerol working model [DOI] 10.1371/journal.pgen.1002219 PMC 바로가기 [Article Type] Research Article
Annexin A2 Binds RNA and Reduces the Frameshifting Efficiency of Infectious Bronchitis VirusResearch Article Published on 2011-08-302022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Annexin Anti-viral AnxA2 bind binding cell proliferation cells cellular cellular mRNAs crosslinking DNA Efficiency Exocytosis functions IBV implicated in vitro involved knockdown metabolism modulate mRNA Protein reduced regulate RNA RNA binding protein shown significantly tested ultraviolet Viral RNA was used [DOI] 10.1371/journal.pone.0024067 PMC 바로가기 [Article Type] Research Article
A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegansCaenorhabditis elegans에서 p38 MAPK 신호 전달의 감소는 면역 노화의 기초가 됩니다Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addressed age aging amplify Author Bacteria Bacterial Bacterial infection Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans change conserved cycle death Decline declines Defense defined Deterioration elegan examined exhibit Genetic Host host defense human pathogen humans immune function immunosenescence impair implicated increase in Infection innate immune Innate immunity intestinal intestinal tissue involved leads MAPK mice mitogen mitogen-activated protein kinase molecular basis molecular mechanism motion pathogen pathway phenomenon PMK-1 proliferation promote Protein protein kinase Pseudomonas aeruginosa regulate signaling pathway susceptibility tissue damage turn [DOI] 10.1371/journal.pgen.1002082 PMC 바로가기 [Article Type] Research Article
Human coronaviruses are uncommon in patients with gastrointestinal illnessArticle Published on 2010-04-012022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, MERS, [키워드] Adult children clinical clinical manifestation Clostridium difficile collected coronavirus detected diarrhea disease emesis Frequency gastrointestinal disease HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HKU1 hospital Human illness implicated included individual infect infectious median neurologic NL63 NO objective occurred Patient pediatric positive positive patient positive sample presenting primer set recorded respiratory complaints respiratory finding respiratory tract Result RNA extraction RT-PCR Sample screened Stool submitted variety Viral gastroenteritis was performed [DOI] 10.1016/j.jcv.2010.03.007 PMC 바로가기 [Article Type] Article
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic ReticulumResearch Article Published on 2008-09-162022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] acute respiratory syndrome alteration Analysis Antiviral applied arising Author biochemical characterized complex connection coronavirus cytoplasm cytosol Defense defined dissect double-stranded RNA driven by early stage electron tomography Endoplasmic reticulum endoplasmic reticulum membrane enzyme ER membrane host cell host cell membrane host cell membranes host cells human pathogen implicated in viral induce Infected infected cell interior invagination mechanism mechanisms membrane membrane-bound membranes Microscopy network question raise replicate Replication replication complex replicative protein reported Reticulum reveal RNA RNA genome RNA synthesis RNA virus RNA viruses SARS-coronavirus SARS-CoV Structure subunits Support thought tomography ultrastructure unique Vesicle vesicles viral replication viral RNA synthesis virus Virus-host interactions Web [DOI] 10.1371/journal.pbio.0060226 PMC 바로가기 [Article Type] Research Article