Efficacy and safety of DPP-4 inhibitor in the treatment of patients with COVID-19 combined with diabetes mellitus A protocol for systematic review and meta-analysis4900 Published on 2020-10-092022-10-30 Journal: Medicine [Category] COVID-19, MERS, SARS, [키워드] adverse outcomes Adverse reactions Analysis blood glucose CBM clinical evidence Clinical improvement clinical trial CNKI Cochrane Library conducted COVID-19 COVID-19 mortality COVID-19 patient Data analysis database diabete diabetes Diabetes Mellitus DPP-4 inhibitors effective Effectiveness Evidence fasting blood fasting insulin Glucose glycosylated hemoglobin include increase independent risk factor Infectious disease inhibitor interleukin-6 Meta-analysis metabolic disease morbidity mortality rate patients with COVID-19 peer-reviewed Primary outcome protocol Randomized controlled trials Registration review shown Symptom systematic review Treatment tumor necrosis factor-alpha VIP Web of Science with COVID-19 [DOI] 10.1097/MD.0000000000022592 PMC 바로가기 [Article Type] 4900
Use of Tocilizumab in COVID-19: A Systematic Review and Meta-Analysis of Current EvidenceInternal Medicine Published on 2020-10-092022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% confidence interval Abstract analyses Analysis anti-IL-6 article articles baseline characteristics biologic agent calculated case-control study collaboration college control arm control group coronavirus disease COVID-19 COVID-19 patients Critical Critically ill current database demonstrated Denmark Efficacy elevated Endpoint Health IL-6 Immunological response Infection intensive care interleukin-6 invasive ventilation material mean difference Meta-analysis Mortality observational studies outcome oxygen saturation Patient patients with COVID-19 pharmacological treatment positive random effect model reducing mortality regimen reported Result review risk risk ratio Safe Safety SARS-CoV-2 searched Seven severe COVID-19 significant difference significantly lower standard care group Stata Corporation Station suggested systematic review Tocilizumab tocilizumab patient treatment with tocilizumab were used [DOI] 10.7759/cureus.10869 PMC 바로가기 [Article Type] Internal Medicine
Preemptive interleukin-6 blockade in patients with COVID-19Article Published on 2020-10-082022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 치료제, [키워드] antibody anticipated Biological blockade C-reactive protein catastrophic clinical manifestation clinical marker collected Comorbidity consequence contributing to COVID-19 criteria Cytokine release syndrome Cytokine storm D-dimer death disease evaluated Final Gender Health care humanized implicated In-hospital inclusion criteria Infectious diseases initial interleukin-6 key factor monoclonal Nasopharyngeal swab nasopharynx non-responder outcome outcomes Patient patients patients hospitalized patients with COVID-19 plasma biomarker predicted predictor predictors Prevent profile receptor Responder Safe severely ill patients Signaling SOFA SOFA score Stage Systolic blood pressure Temporal the SARS-CoV-2 therapy Tocilizumab treated with COVID-19 [DOI] 10.1038/s41598-020-74001-3 PMC 바로가기 [Article Type] Article
Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and ImplicationsSARS-CoV-2 및 ACE2 증강으로 유발된 염증은 심각한 COVID-19의 다발성 장기 부전을 유발합니다: 분자 메커니즘 및 의미Review Published on 2020-10-082022-09-10 Journal: Inflammation [Category] MERS, 바이오마커, [키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggravate Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bind cascade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokine storm Cytokines develop downregulation drive Evidence failure functional high mortality host cell host cells Inflammation Inflammatory responses Injury interleukin interleukin-6 lead Lung injury Macrophage macrophages massive mechanism monocyte Monocytes Multiple multiple organ dysfunction multiple organ dysfunction/failure multiple organ failure Necrosis NFκB nuclear Occurrence organ dysfunction organs pandemic pathological change pathological changes patients of COVID-19 receptor released Renin renin-angiotensin system replicate respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe patients Severe patients of COVID-19 Spike protein syndrome TNFα Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha widespread [DOI] 10.1007/s10753-020-01337-3 PMC 바로가기 [Article Type] Review
A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19Research article Published on 2020-10-082022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] 95% CI adjusted age and sex analysed association Award baseline Biomarker calculated Care clinical Clinical outcome COVID-19 Cytokines determine finding Francis funding help hospitalized COVID-19 patients identify IL-10 IL-6 increase in Inflammation interleukin-10 interleukin-6 linear Logistic regression mechanical ventilation opportunity outcome patients hospitalized performed predict predictor Prognosis prognostic prognostic score required significantly Society Therapies was used [DOI] 10.1016/j.ebiom.2020.103026 [Article Type] Research article
Health Disparities in COVID-19: Addressing the Role of Social Determinants of Health in Immune System Dysfunction to Turn the TidePublic Health Published on 2020-10-082022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] amplified caused COVID-19 COVID-19 pandemic cytokine Cytokine storm determinant disparity exposure to Health Health disparities help IL-6 immune response immune system Immune system dysfunction implication increases in Inflammatory responses interleukin-6 novel coronavirus SARS-CoV-2 occur pandemic Pandemics Psychoneuroimmunology Psychosocial stress reduce resulting role social determinant social determinants Stress System tide vulnerable patient [DOI] 10.3389/fpubh.2020.559312 PMC 바로가기 [Article Type] Public Health
Outlook of IL-6 signaling blockade for COVID-19 pneumoniaReview Published on 2020-10-052022-10-30 Journal: Inflammation and Regeneration [Category] COVID-19, [키워드] blockade Combination COVID-19 COVID-19 pneumonia Cytokine release syndrome disease Efficacy function Hospitalized hospitalized patient IL-6 IL-6 signaling implication inflammatory condition inhibitor inhibitors interleukin-6 physiological placebo-controlled study pleiotropic Pneumonia Population Randomized real-world data sarilumab Severe COVID-19 pneumonia siltuximab Standard of care therapeutic option Tocilizumab treat Treatment treatment for COVID-19 Trial unmet need [DOI] 10.1186/s41232-020-00134-7 PMC 바로가기 [Article Type] Review
SARS-CoV-2 antibodies, serum inflammatory biomarkers and clinical severity of hospitalized COVID-19 patientsResearch article Published on 2020-10-012022-10-05 Journal: Journal of Clinical Virology [Category] SARS, 바이오마커, [키워드] analyzed anti-RBD antibody approaches association Blood C reactive protein Clinical data Clinical severity collected comparable Complete correlation COVID-19 COVID-19 patient COVID-19 severity CRP demographic different time point domain ELISA event exhibited ferritin GFP hospitalized COVID-19 patient hospitalized patient ICU ICU patient IgG IgGs IL-6 inflammatory biomarkers intensive care interleukin-6 investigated LDH Neutralizing antibodies neutralizing antibody non-ICU patient onset of symptom Patient platform pro-inflammatory biomarkers Protein Pseudotyped virus RBD recognizing Result retrieved retrospective SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 RBD sera serum inflammatory biomarker Serum level suggested Support were measured [DOI] 10.1016/j.jcv.2020.104611 [Article Type] Research article
Clinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis2019년 중증 또는 중대한 신종 코로나바이러스 감염증(COVID-19)과 관련된 임상 실험실 매개변수: 체계적인 검토 및 메타 분석Research Article Published on 2020-10-012022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval Adaptive immune response articles C-reactive protein calculated carried CD4 CD8 T cell cell counts children CINAHL Clinical course clinical laboratory conducted confirmed case confirmed cases coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 cases Critical Critical disease D-dimer data extraction database databases dimer eligible excluded Google Scholar innate immune response interleukin interleukin-6 Laboratory laboratory parameter lymphocyte marker meta-analyses Meta-analysis MMD MONITOR neutrophil neutrophil count notable novel coronavirus disease observational studies observational study Organ failure Other parameter predictor pregnant women proportion random effect relative reported severity systematic review systematic reviews T cell tissue damage troponin troponin I Web of Science [DOI] 10.1371/journal.pone.0239802 PMC 바로가기 [Article Type] Research Article
Cytokine prediction of mortality in COVID19 patientsArticle Published on 2020-10-012023-07-11 Journal: Cytokine [Category] SARS, [키워드] Coronavirus disease 2019 interleukin-1β interleukin-6 interleukin-8 Mortality pro-inflammatory cytokines Tumor necrosis factor alpha. [DOI] 10.1016/j.cyto.2020.155190 PMC 바로가기