Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies치료 및 백신 설계 전략을 안내하기 위한 SARS-CoV-2 스파이크 중화 에피토프의 구조 분석Review Published on 2021-01-192022-09-01 Journal: Viruses [Category] 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus binding mode binding modes can be used caused coronavirus correlation correlations COVID-19 COVID-19 pandemic domain Effect feature guide highlight immunogen in vivo mAb mAbs MERS Middle East Middle East respiratory syndrome monoclonal antibodies monoclonal antibody N-terminal domain nCoV Neutralizing Neutralizing antibodies prophylactically Receptor-binding domain Research respiratory SARS-CoV-2 SARS-CoV-2 spike Severe acute respiratory syndrome spike Strategy syndrome target the SARS-CoV-2 Vaccine [DOI] 10.3390/v13010134 PMC 바로가기 [Article Type] Review
Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2SARS-CoV-2 진입의 Hydroxychloroquine 매개 억제는 TMPRSS2에 의해 약화됩니다Research Article Published on 2021-01-192022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, [키워드] ablated activate activated activating antiviral activities antiviral activity Autoimmune disorders block cathepsin L Cathepsins cause Cell cell entry cell surface cell-culture studies cell-culture systems Chloroquine cleave clinically Combination combinations coronavirus COVID-19 COVID-19 patient dependent on Efficacy endocytosis Endosomal acidification endosomal protease explain functional furin furin cleavage site furin-cleavage site global public health human clinical trial human clinical trials Hydroxychloroquine identify in vivo Infection inhibit inhibit SARS-CoV-2 interfere introduced lack malaria membrane fusion observé pathogenic coronavirus pathway plasma plasma membrane Prevent protease TMPRSS2 Protein Proteins proteolytic activity Receptor binding reversed S protein S proteins SARS Coronavirus SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike shown target cell target cells tested the cell the SARS-CoV-2 these compounds TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor TMPRSS2 pathway treat treated treatment for COVID-19 utility Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1009212 PMC 바로가기 [Article Type] Research Article
Methylene Blue Inhibits the SARS-CoV-2 Spike–ACE2 Protein-Protein Interaction–a Mechanism that can Contribute to its Antiviral Activity Against COVID-19Pharmacology Published on 2021-01-132022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] absence ACE2 ACE2-expressing cell activated activity Against Antiviral antiviral activity approved blood product blue Chloroquine Compound contribute coronavirus COVID-19 COVID-19 pandemic Critical Erythrosine B FDA half-maximal inhibitory concentration identify inactivation Inhaled inhibit inhibited inhibitor inhibitory activity initiated Interaction medication Methylene Methylene blue PPI protein-protein interaction pseudovirus receptor ACE2 responsible SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein shown Spike protein Suramin the SARS-CoV-2 Treatment virus [DOI] 10.3389/fphar.2020.600372 PMC 바로가기 [Article Type] Pharmacology
No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor직접적인 SARS-CoV-2 스파이크 결합 수용체로서의 Basigin/CD147에 대한 증거 없음Article Published on 2021-01-112022-09-10 Journal: Scientific Reports [Category] Coronavirus, MERS, 치료기술, 치료제, [키워드] ACE2 Basigin binding Cas9 CD147 CLARITY clinical trial COVID-19 CRISPR detect entry receptor epithelial cell epithelial cells Evidence expressed form host receptor Host receptors human cell human cells human lung human lung epithelial cells hypothese in viral Infection Interaction isoform lead mechanism Pathogenesis receptor recombinant SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike Spike protein spike protein of SARS-CoV-2 susceptibility target the SARS-CoV-2 translational treat Viral viral infection viral invasion Viral proteins viral spike protein virus [DOI] 10.1038/s41598-020-80464-1 PMC 바로가기 [Article Type] Article
In silico validation of potent phytochemical orientin as inhibitor of SARS-CoV-2 spike and host cell receptor GRP78 bindingResearch Article Published on 2021-01-112022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] In silico docking acute respiratory syndrome Anti-inflammation antinociceptive Antiviral binding contagious coronavirus COVID-19 docking domain drug Effect effective Effects GRP78 Health host cell receptor host receptor in silico inhibitor Interaction interfere MD simulation measure Molecular dynamics simulation Orientin outbreak overlapping pandemic phytochemical plant Research residue SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein Simulation spread to Still the disease therapeutic Treatment Vaccine vasodilatation Wuhan, China [DOI] 10.1016/j.heliyon.2021.e05923 PMC 바로가기 [Article Type] Research Article
A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection Research Published on 2021-01-112022-10-05 Journal: Nature Genetics [Category] 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding ACE2 expression airway epithelial cell airway epithelium amino acids Cell contribute Critical enzyme expressed FIVE high-affinity binding Host host susceptibility identify in viral Infection interferon interferon stimulation isoform lack plasma membrane Protein respiratory epithelia respiratory virus resulting rhinovirus RNA RNA genome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike the SARS-CoV-2 thought transcript Trigger unlikely upregulated viral infection [DOI] 10.1038/s41588-020-00759-x [Article Type] Research
Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infectionsSARS-CoV-2 감염 치료를 위한 2-MAb 칵테일의 개발 및 구조적 기초Article Published on 2021-01-112022-09-12 Journal: Nature Communications [Category] 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered antibody antibody cocktail Antiviral effect binding caused characterization complex complexes conformational coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo-EM structure cryo-EM structures determine development drug Drug development epitope Epitopes exhibit expressed Fab groups humanized IC50 identify in vitro information inhibitory concentration Interaction mAbs mice Microbiology monoclonal antibodies monoclonal antibody mouse model neutralize Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibody option pandemic Post-infection Prophylaxis Protein RBD Receptor-binding domain representing respiratory S trimer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Spike protein structural biology the receptor-binding domain the SARS-CoV-2 therapeutic treat treating COVID-19 treating SARS-CoV-2 infection trimeric S protein two group two groups [DOI] 10.1038/s41467-020-20465-w PMC 바로가기 [Article Type] Article
SARS-CoV-2 Epitope Mapping on Microarrays Highlights Strong Immune-Response to N Protein RegionArticle Published on 2021-01-112022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] click chemistry Cohort collected common cold coronavirus COVID-19 cross-reactivity diagnostic epitope epitope mapping healthy individuals high-density IgG IgM immunodominant immunoreactivity implementation independent mapping Microarray N protein nucleocapsid peptide peptide microarray peptide microarrays polyprotein positive probe Protein reached Region reported SARS-CoV-2 SARS-CoV-2 spike sensitivity sera serological serological test serum sample specificity Strong symptoms onset tested the N protein [DOI] 10.3390/vaccines9010035 PMC 바로가기 [Article Type] Article
Host and viral determinants for efficient SARS-CoV-2 infection of the human lungArticle Published on 2021-01-082022-10-29 Journal: Nature Communications [Category] COVID-19, [키워드] ACE2 addition contribute determinant epithelial cell Ex vivo Factor furin-like cleavage site Host human cell human lung identify Infection Intervention intestinal tissues involved lung epithelial cell lung tissues Lungs Pathogenesis Prevent required restriction factor SARS-CoV infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sialic acid target tissue tissues Transmissibility understanding viral infection virus replication while [DOI] 10.1038/s41467-020-20457-w PMC 바로가기 [Article Type] Article
Rapid GMP-Compliant Expansion of SARS-CoV-2–Specific T Cells From Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19COVID-19에 대한 동종 세포 치료제로 사용하기 위한 회복기 기증자의 SARS-CoV-2-특정 T 세포의 신속한 GMP 준수 확장Immunology Published on 2021-01-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법, [키워드] accumulation adoptive T cell immunotherapy Allogeneic Antigen antigens approach Blood Blood donations can be used caused CD4 CD8 cellular central memory characterized convalescent COVID-19 COVID-19 disease COVID-19 patients Culture Donor dysregulation effector T cell effector T cells expand expansion membrane memory T cell memory T cells nucleocapsid patients peptides phenotype Potential treatment Rapid reagent recognize SARS-CoV-2 spike SARS-CoV-2 virus selected T cell T cell response T cell responses T cells the SARS-CoV-2 virus therapeutic dose therapeutic doses therapy virus virus-specific T cell viruses [DOI] 10.3389/fimmu.2020.598402 PMC 바로가기 [Article Type] Immunology