Effects of rapid recruitment and dissemination on Covid-19 mortality: the RECOVERY trial신속한 모집 및 보급이 Covid-19 사망률에 미치는 영향: RECOVERY 시험Opinion Article Published on 2020-12-232022-09-11 Journal: F1000Research [Category] MERS, 임상, [키워드] adaptive Analysis COVID-19 decreased mortality demonstrated Dexamethasone dissemination Effect eligible patient Eligible patients hospitalised patient Hospitalised patients Hydroxychloroquine Mortality oxygen pandemic Patient randomised controlled trial RECOVERY trial recruited recruitment reduce reducing mortality significantly speed supplemental oxygen Treatment Trial ventilator [DOI] 10.12688/f1000research.25842.2 PMC 바로가기 [Article Type] Opinion Article
Prognostic factors and predictors of outcome in patients with COVID-19 and related pneumonia: a retrospective cohort studyCOVID-19 및 관련 폐렴 환자의 예후 인자 및 예후 인자: 후향적 코호트 연구Virology Published on 2020-12-232022-09-10 Journal: Bioscience Reports [Category] MERS, 치료제, [키워드] ACE-inhibitors adopted Affect Anticoagulant treatment baseline Brescia Cancer cardiovascular risk factor cardiovascular risk factors chronic obstructive chronic obstructive pulmonary disease clinical benefit co-morbidity consecutive patient COVID-19 death demonstrated Dexamethasone diabetes died discharge disease dose drugs enoxaparin Factor Follow-up heart disease Hospital admission Hospitalization Hydroxychloroquine hypertension in some In-hospital Italy Lopinavir morbidities morbidity obstructive pulmonary disease once daily outcome patients patients died patients with COVID-19 Pneumonia predictor Prognosis pulmonary disease radiologic Respiratory failure retrospective cohort study risk of death Ritonavir SARS-CoV-2 SARS-CoV2 survival Tocilizumab treated Treatment treatment with tocilizumab variable were assessed worse prognosis [DOI] 10.1042/BSR20203455 PMC 바로가기 [Article Type] Virology
The Need for Antiviral Drugs for Pandemic Coronaviruses From a Global Health PerspectiveMedicine Published on 2020-12-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Administered Antiviral antiviral drugs antiviral therapy caused clinical study clinical trial conserved coronavirus Coronaviruses COVID-19 COVID-19 pandemic creating Dexamethasone disease stage drug Drug discovery drugs early treatment effective global health hospital hospitalized patients Infection influenza viruses Interaction investigated majority Mortality outbreak preparedness pandemic pharmacotherapy Prevent recovery Remdesivir respiratory respiratory viral infection respiratory virus SARS-CoV-2 solidarity Stage symptom duration target product profile the disease the United State Treatment viral dynamics Viral load Viral pneumonia Viral protein widespread [DOI] 10.3389/fmed.2020.596587 PMC 바로가기 [Article Type] Medicine
Altitude and COVID‐19: Friend or foe? A narrative reviewOriginal Research Published on 2020-12-192022-10-28 Journal: Physiological Reports [Category] COVID-19, MERS, [키워드] aggravate altitude antioxidant ARDS Characteristics Clinical practice condition conditions coronavirus Corticosteroid COVID‐19 detrimental Dexamethasone dose Effect effective Effects elevated Epidemiology evaluated Evidence Friend healthy individuals heart failure Hypoxemia hypoxia hypoxic illness immune system Immunity incidence individual instance knowledge mechanisms Mitochondria mitochondrial Mortality MOST novel coronavirus disease overlap oxygen supply pandemic pathology pathophysiological pathophysiology Patient physiological response Prevent prophylactic measure recent reported Research responses risk SARS‐CoV‐2 infection similarity Symptom Symptoms treat Treatment treatment strategy while [DOI] 10.14814/phy2.14615 PMC 바로가기 [Article Type] Original Research
A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Severity in Syrian Hamsters시리아 햄스터의 바이러스 부담과 질병 중증도를 감소시키는 강력한 SARS-CoV-2 중화 인간 단일클론 항체Immunology Published on 2020-12-182022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] antibody approach burden caused Clinical management clone contributed coronavirus COVID COVID-19 COVID-19 patients deaths demonstrated Dexamethasone disease disease severity Efficacy hamster Histopathology Human Human monoclonal antibody immunopathological in vitro infiltration Lungs monoclonal Ab monocyte morbidity neutralized pandemic potent Receptor binding domain reduced reducing reduction Remdesivir SARS-CoV-2 significantly specificity Spike protein the SARS-CoV-2 therapeutic antibodies therapy Treatment Viral load virus yeast [DOI] 10.3389/fimmu.2020.614256 PMC 바로가기 [Article Type] Immunology
Efficacy and safety of mesenchymal stem cells for the treatment of patients infected with COVID-19: a systematic review and meta-analysis protocol코로나19 환자 치료를 위한 중간엽줄기세포의 효능 및 안전성: 체계적 고찰 및 메타분석 프로토콜Article Published on 2020-12-182022-08-31 Journal: BMJ Open [Category] MERS, meta-analysis, SARS, [키워드] academic conference adverse events antivirus drug assessment bias risk Biomarker Biomarkers Case series case sery CBM Cell Cell Biology changes in chest pain China Chinese CINAHL CNKI Cochrane Library collected conducted Controlled trial COVID-19 pandemic critical cases data extraction database development Dexamethasone difficulty difficulty breathing dose duration of fever Efficacy and safety eligibility criteria Ethical approval Ethics evaluate Evidence high mortality immunology inception incidence include Infectious diseases Infrastructure journal Laboratory laboratory examination life literature mesenchymal stem cell Meta-analysis Mild moderate moderate to severe Mortality movement MSC MSC therapy Patient patients with COVID-19 peer-reviewed performed pressure Prevent Primary outcome Primary outcomes progression PROSPERO protocol public health Quality of life Randomised controlled trials reduce registration number respiratory searched secondary outcome Secondary outcomes sensitivity analysis service severity Shortness of breath SinoMed speech stem cell strength Symptom System systematic review Therapeutic approach therapy treat Treatment Vaccine ventilator VIP Web of Science [DOI] 10.1136/bmjopen-2020-042085 PMC 바로가기 [Article Type] Article
Vasculature-Associated Lymphoid Tissue: A Unique Tertiary Lymphoid Tissue Correlates With Renal Lesions in Lupus Nephritis Mouse ModelOriginal Research Published on 2020-12-152023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] chemokine Dexamethasone kidney lupus nephritis renal lesions tertiary lymphoid tissue [DOI] 10.3389/fimmu.2020.595672 PMC 바로가기 [Article Type] Original Research
Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomesResearch Published on 2020-12-142022-11-01 Journal: Critical Care [Category] COVID-19, MERS, [키워드] 28-day mortality 95%CI antibiotic use benefit Clinical outcome coronavirus Corticosteroid Corticosteroids COVID-19 Dexamethasone Effectiveness evaluate Hospital stay increase in Infection mechanical ventilation Meta-analysis Mortality objective observational study outcome Oxygen therapy Patient patients positive quantified ranged RCT RCTs RECOVERY trial reduced reduction in reported respiratory specimens Result RT-PCR SARS-CoV-2 SARS-CoV-2 pandemic secondary secondary infections shown Standard of care systematic literature search systematic review use of corticosteroid viral clearance was performed Web of Science [DOI] 10.1186/s13054-020-03400-9 PMC 바로가기 [Article Type] Research
Diagnosis and Management of Acute Respiratory Distress Syndrome in a Time of COVID-19Review Published on 2020-12-062022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Accuracy acute respiratory distress syndrome (ARDS) ARDS avoidance cause characterized chest imaging Clinical outcome clinical suspicion complications condition Coronavirus disease 2019 Course COVID-19 COVID-19 patient COVID-19-associated ARDS Critical care Dexamethasone Diagnosis diagnosis of ARDS disease distress Future High flow nasal oxygen hypoxemic iatrogenic IMPROVE improve clinical outcomes intubation Invasive mechanical ventilation laboratory feature management mechanical ventilation Mild morbidity and mortality nasal oxygen Non-invasive respiratory support non-invasive ventilation outcome pathology Patient patients with ARDS physiological Pneumonia Remdesivir resource resources respiratory Respiratory failure Respiratory Support SARS-CoV-2 SARS-COV-2 infection Sepsis Stage syndrome therapy time [DOI] 10.3390/diagnostics10121053 PMC 바로가기 [Article Type] Review
Interrelated Mechanism by Which the Methide Quinone Celastrol, Obtained from the Roots of Tripterygium wilfordii , Inhibits Main Protease 3CL pro of COVID-19 and Acts as Superoxide Radical ScavengerArticle Published on 2020-12-042022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] 3CL pro Act Amino acid amino acids antioxidant celastrol coronavirus disease covalent bond COVID-19 cyclic voltammetry described Dexamethasone effective functional HIS164 His41 inhibitor Interaction mechanism medication methide quinone molecular molecular mechanism observé oxygen Patient protease quinone Radical root scavenger scavenging severe symptoms Superoxide supported thiolate transfer X-ray diffraction [DOI] 10.3390/ijms21239266 PMC 바로가기 [Article Type] Article