Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective ReviewReview Published on 2021-07-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 3D structure acute respiratory syndrome antigenic epitope bioinformatics bioinformatics resources caused computational tool contagious coronavirus coronavirus strain coronavirus vaccine COVID-19 database death disease effective effort epitope experimental validation function Genome sequencing genomic globe immune response immunoinformatics in viral pandemic pathogen platform Protein researcher resource resources review SARS-CoV-2 Stage target the vaccine Vaccine vaccine construct valuable resource [DOI] 10.3390/vaccines9080812 PMC 바로가기 [Article Type] Review
Highly feasible immunoprotective multicistronic SARS-CoV-2 vaccine candidate blending novel eukaryotic expression and Salmonella bactofection새로운 진핵생물 발현과 살모넬라 박토펙션을 혼합한 매우 실현 가능한 면역보호 멀티시스트론 SARS-CoV-2 백신 후보Article Published on 2021-07-222022-09-11 Journal: Journal of advanced research [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis anti-SARS-CoV-2 immune responses Antibody titers antigen-specific antibody Antiviral CD4 CD8 Cell-mediated immunity Cellular immune response co-expression COVID-19 Cytometry demonstrated determine develop DNA domain effective Efficacy Efficiency elicited epitope Epitopes eukaryotic expressing expression feasible Flow flow cytometry Frame fused gene delivery heptad repeat highest humoral immune responses immunized mice immunofluorescence assay immunogenicity IMPROVE in vivo increase in investigated mechanism membrane protein mice mRNA Multicistronic expression multivalent vaccine neutralizing antibody titers nsp13 offer Open reading frame pandemic peptide polarization Protein protein expression raised RBD recall Receptor-binding domain recorded RNA robust Safe Salmonella SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes SARS-CoV-2 neutralizing antibody SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein splenocyte splenocytes suggested T cell T cells targets Th1 Th1 response Th2 immunity the spike protein the vaccine Vaccine vaccine candidate vaccine construct variant variants were used western blot Western blot analysis [DOI] 10.1016/j.jare.2021.07.007 PMC 바로가기 [Article Type] Article
The Characteristics of Spike Glycoprotein Gene of Swine Acute Diarrhea Syndrome Coronavirus Strain CH/FJWT/2018 Isolated in ChinaVeterinary Science Published on 2021-07-222022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] acute diarrhea affected Amino acid Analysis analyzed B cell epitope cell tropism cellular receptor characterized China contagious coronavirus country Critical determine diarrhea epitope family Coronaviridae full-length genome genetic diversity Guangdong host range Infectious disease Interaction Isolated isolates linear Neonatal Neutralizing antibodies Phylogenetic analysis predicted Region similarity spike spike glycoprotein spike glycoprotein gene strain Surveillance swine acute diarrhea syndrome coronavirus (SADS-CoV) syndrome tissue tropism Variation viral isolate virus virus genome virus infection vomiting watery [DOI] 10.3389/fvets.2021.687079 PMC 바로가기 [Article Type] Veterinary Science
Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutantsArticle Published on 2021-07-202022-10-04 Journal: Cell Discovery [Category] 변종, [키워드] acute respiratory syndrome antibody antibody cocktail caused Coronaviral coronavirus Coronavirus disease 2019 COVID-19 Cryo-electron microscopy Cryoelectron microscopy death effective eliminated epitope epitope mapping evade experiment group involved Measures mice mutant Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody pandemic disease Pattern recognition receptors performed provide RBD residue SARS-CoV-2 strain the receptor-binding domain therapeutic Threats variant [DOI] 10.1038/s41421-021-00292-z PMC 바로가기 [Article Type] Article
Bioinformatics Prediction of SARS-CoV-2 Epitopes as Vaccine Candidates for the Colombian PopulationArticle Published on 2021-07-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] allele Analysis Antigen AutoDock binding candidate caused CD4 CD8 coronavirus SARS-CoV-2 country Coverage COVID-19 death disease epitope global public health HLA identify immune response Immuno-informatics immunogenicity in silico include Infection Interaction leukocyte molecular docking NetMHCpan pandemic peptide performed Population predicted prediction promote Protein SARS-CoV-2 SARS-CoV-2 epitope Severe acute respiratory syndrome T-cell epitope Toxicity Vaccine design virus [DOI] 10.3390/vaccines9070797 PMC 바로가기 [Article Type] Article
Immune cell profiling in atherosclerosis: role in research and precision medicine Reviews Published on 2021-07-152022-10-05 Journal: Nature reviews. Cardiology [Category] 신약개발, [키워드] alteration Atherosclerosis atherosclerotic atherosclerotic plaque cardiovascular disease cardiovascular event cardiovascular risk Cell cellular cellular and molecular clinical trial CRISPR Cytometry data-driven early phase epitope experimental models group Human identify immune immunotherapies Immunotherapy Inflammation involved mouse model Myocardial infarction Patient patient population patients Precision randomized clinical trial reduce Research review Sequencing single-cell Single-cell RNA sequencing Stage These data Transcriptome translation treat treated patients [DOI] 10.1038/s41569-021-00589-2 [Article Type] Reviews
Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity최첨단: 뉴클레오캡시드 백신은 스파이크 독립적인 SARS-CoV-2 보호 면역을 유도합니다Article Published on 2021-07-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adenovirus challenge concern coronavirus Coverage COVID-19 pandemic Cutting defined effector mechanisms epitope expressing focus hamster immune K18-hACE2 mice mice mucosa neutralize Neutralizing nucleocapsid protective immunity Protein rationale recall Receptor binding domain reduced respiratory respiratory mucosa response responsible SARS-CoV-2 SARS-CoV-2 vaccines severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support T cell target the SARS-CoV-2 vaccination Vaccine vaccine immunity variants Viral Viral load weight loss [DOI] 10.4049/jimmunol.2100421 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants스파이크 당단백질을 기반으로 한 SARS-CoV-2 백신 및 새로운 바이러스 변이체의 의미Review Published on 2021-07-122022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect antibody antigenic cause caused clinical manifestation clinical manifestations company Complete coronavirus COVID-19 death domain effective Effectiveness epitope Epitopes glycoprotein Human Infection Mild neutralize Neutralizing antibodies New new SARS-CoV-2 Protein RBD Receptor-binding domain resistance to neutralization respiratory Respiratory system S glycoprotein SARS-CoV-2 SARS-CoV-2 variants spike glycoprotein the receptor-binding domain the Spike Vaccine Vaccine design Vaccine development Vaccines variant Wuhan Wuhan, China [DOI] 10.3389/fimmu.2021.701501 PMC 바로가기 [Article Type] Review
Deep learning identifies antigenic determinants of severe SARS-CoV-2 infection within T-cell repertoiresArticle Published on 2021-07-122022-10-04 Journal: Scientific Reports [Category] SARS, 진단, [키워드] Analysis antigenic asymptomatic infection Biomarkers characterized Classifier Clinical course Clinical outcome clinical presentation Cohort Computational biology and bioinformatics Computational models Critical care database deep deep learning determinant Diseases epitope Evidence Factor Genome informatics identify ImmuneCODE immunology individual Infection machine learning management Medical research Patient physician predict responses SARS-CoV-2 epitope SARS-COV-2 infection Sequencing Severe infection severe SARS-CoV-2 severity Support T-cell T-cell receptor T-cell Response Variation [DOI] 10.1038/s41598-021-93608-8 PMC 바로가기 [Article Type] Article
Possible Targets of Pan-Coronavirus Antiviral Strategies for Emerging or Re-Emerging CoronavirusesReview Published on 2021-07-102022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Antiviral antiviral strategy caused Contact coronavirus Coronaviruses COVID-19 Critical develop drug epitope Human humans imperative inhibitor pan-coronavirus pandemic predicted Research respiratory SARS-CoV-2 Spread Strategy target the disease Treatment Vaccine Vaccines virus worldwide pandemic [DOI] 10.3390/microorganisms9071479 PMC 바로가기 [Article Type] Review