BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial)의료 종사자에서 Covid-19의 영향을 줄이기위한 BCG 예방 접종 : 무작위 대조 시험을위한 프로토콜 (Brace Trial)Infectious Diseases Published on 2021-10-272022-09-10 Journal: BMJ Open [Category] Fulltext, MERS, SARS, 임상, [키워드] 1:1 Analysis approval BCG BCG vaccination Blood Blood samples Brazil changes in ClinicalTrials collected control group Controlled trial COVID-19 database determine dissemination episode of Ethics evaluated Factor febrile Final group HCW HCWs healthcare healthcare worker Healthcare workers identify immune response immune responses immune system Immunological analyses immunology incidence infections Infectious diseases International Intervention Microbiology modulate multicentre Netherlands outcomes participant Pathogens peer-reviewed questionnaire Questionnaires randomised controlled trial reduce Repository respiratory Respiratory illness Result safety profile SARS-CoV-2 SARS-COV-2 infection Secondary objectives severe COVID-19 severity Spain susceptibility symptomatic tested Trial Trial registration vaccination Virology [DOI] 10.1136/bmjopen-2021-052101 PMC 바로가기 [Article Type] Infectious Diseases
Evaluation of the Effect of Inactivated Transmissible Gastroenteritis Virus Vaccine with Nano Silicon on the Phenotype and Function of Porcine Dendritic CellsArticle Published on 2021-10-262022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation characterized coronavirus cytokine cytokine receptor DCs dendritic cell disease Effect ENhance function gastroenteritis help IFN-α IL-12 IL-1β IL-6 immature immune responses inactivated inactivated TGEV vaccine indicated Innate immunity mechanism MSN nano silicon phenotype Research Safe significantly higher silicon TGEV TLR10 TLR3 TLR5 TLR7 TLR9 TNF-α Vaccine virus [DOI] 10.3390/v13112158 PMC 바로가기 [Article Type] Article
Longitudinal humoral antibody response to SARS-CoV-2 infection among healthcare workers in a New York City hospital뉴욕시 병원의 의료 종사자들 사이에서 SARS-CoV-2 감염에 대한 세로 체액성 항체 반응Article Published on 2021-10-262022-09-11 Journal: BMJ Open [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] addition age anti-S anti-S antibody antibodies antibody Antibody Response Asymptomatic clinical symptom Clinical symptoms completion conducted correlation COVID-19 COVID-19 symptom COVID-19 symptoms decay detect Diseases domain duration of symptom Dynamics ELISA evaluate faster Fever followed by full-length S Gastrointestinal symptom gastrointestinal symptoms HCW HCWs healthcare worker Healthcare workers hospital humoral humoral immune response humoral immune responses Humoral response immune responses immunology Infection Infectious diseases initial longitudinal longitudinal study Mount Sinai New York New York City outcome participant participated Phase 1 Phase 2 positive positive correlation Protein Quantitative reactive Receptor-binding domain S protein SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 PCR serology testing Significant South subject subsequent symptomatic System titre Viral was performed [DOI] 10.1136/bmjopen-2021-051045 PMC 바로가기 [Article Type] Article
Induction of trained immunity by influenza vaccination – impact on COVID-19인플루엔자 예방접종을 통한 훈련된 면역 유도 - 코로나19에 미치는 영향Observational Study Published on 2021-10-252022-09-10 Journal: PLoS Pathogens [Category] MERS, 유전자 메커니즘, 임상, [키워드] affected anti-SARS-CoV-2 assays caused claimed COVID-19 COVID-19 incidence COVID-19 vaccine cross-protection decrease distribution Effects epidemiological Epidemiological study fine-tune flu healthcare worker help hospital identify Immune cell immune cells immune responses Immunity immunological inactivated induction Influenza influenza vaccination influenza vaccine innate immune response innate immune responses Innate immunity investigated less lower risk mechanism mind monocyte Monocytes observation pandemic potential benefit potential benefits protective effect proteomics randomized trial reduced Relative risk reported reveal risk reduction Safe SARS-CoV-2 SARS-COV-2 infection Seasonal influenza Single-cell RNA sequencing suggested systemic inflammation transcriptional vaccination vaccination against COVID-19 Vaccine variant Viral virus [DOI] 10.1371/journal.ppat.1009928 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 UK, South African and Brazilian Variants in Karachi- PakistanMolecular Biosciences Published on 2021-10-252022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] African Analysis approach B.1.1.7 B.1.351 country COVID-19 COVID-19 pandemic detect genomic gold standard group help immune responses Karachi ORF1a P.1 pandemic PCR PCR assay performed positive sample pursuit responsible RT-qPCR Sample SARS-CoV-2 SARS-CoV-2 (2019-nCoV) SARS-CoV-2 variants Sequencing South Surveillance Transmissibility two groups United Kingdom variants variants of concern VoC Δ69-70 [DOI] 10.3389/fmolb.2021.724208 PMC 바로가기 [Article Type] Molecular Biosciences
Genomic characterization and Epidemiology of an emerging SARS-CoV-2 variant in Delhi, India인도 델리에서 신흥 SARS-COV-2 변형의 게놈 특성 및 역학Article Published on 2021-10-222022-09-10 Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 변종, 유전자 메커니즘, [키워드] (Alpha) antibody B.1.1.7 Bayesian city Cohort Combination Concentration contributed COVID-19 case COVID-19 cases Delta delta variant explain growth advantage immune response immune responses Immunity India median National outbreak reached reduced reduction replaced SARS-CoV-2 SARS-CoV-2 variant sensitivity Seropositivity Transmissibility variant variant B.1.617.2 [DOI] 10.1126/science.abj9932 PMC 바로가기 [Article Type] Article
An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunityResearch article Published on 2021-10-222022-10-05 Journal: Cell chemical biology [Category] SARS, 치료제, [키워드] ACE2 Activation acute respiratory syndrome angiotensin-converting enzyme 2 Antiviral antiviral immunity biotinylated caused Clinical treatment Compound coronavirus coronavirus disease Coronavirus-2 COVID-19 domain drug Epidemic Human human cell humans identify immune responses Infection inhibit Interaction interactome ITGB1 knowledge labeling lysine MAVS mechanism membrane protein methyltransferase mitochondrial mitochondrial antiviral-signaling protein pathway Protein provide proximal proximity labeling replication of SARS-CoV-2 resource reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein SET SETD2 significantly the interferon Treatment TurboID viral infection Viral protein [DOI] 10.1016/j.chembiol.2021.10.008 [Article Type] Research article
Sex-Related Differences in Innate and Adaptive Immune Responses to SARS-CoV-2Immunology Published on 2021-10-202022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation addition CD86 chemokine complications Coronavirus disease 2019 COVID-19 CTLs CXCL-10 DCs dendritic cell dendritic cells difference exhibit expression female females healthy HLA-DR Hospitalization IFN-α immune responses in vitro individual Infection initial Innate innate immune response interferon-α lung male males mDC mDCs mechanism monocyte Monocytes mononuclear cell morbidity and mortality not significant PBMC PBMCs pDC pDCs Peripheral blood response responsible reversed SARS-CoV-2 secreted secretion severe disease Sex sex differences significantly higher stimulated Symptoms the patient these cell Treatment upregulated virus [DOI] 10.3389/fimmu.2021.739757 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 Antibody Binding and Neutralization in Dried Blood Spot Eluates and Paired Plasma건혈 반점 용출액 및 짝을 이루는 혈장에서 SARS-CoV-2 항체 결합 및 중화Research Article Published on 2021-10-202022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, [키워드] 384-well format acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adoption ambient ambient temperature antibodies antibody Antibody binding Antibody Response Antibody responses binding Blood cold chain cold temperatures collected convalescent coronavirus correlated COVID-19 COVID-19 pandemic Critical dried blood spot Dried blood spots ELISA Eluate enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope epitope mapping equipment evaluate feature fingerstick immune response immune responses Infection invasive Longevity MOST natural infection neutralization assays Neutralizing antibodies neutralizing antibody overcome phage display plasma plasma antibody Population profile reflected respiratory responses risk SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 neutralization SARS-CoV-2 variant sera severe acute respiratory syndrome Coronavirus specific antibodies spot storage Support temperature vaccinated individuals vaccination variety venipuncture venous venous blood while [DOI] 10.1128/Spectrum.01298-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Vaccine Induced Atypical Immune Responses in Antibody Defects: Everybody Does their Best항체 결함에서 SARS-CoV-2 백신 유도 비정형 면역 반응: 모두가 최선을 다합니다Original Article Published on 2021-10-202022-09-12 Journal: Journal of Clinical Immunology [Category] MERS, SARS, 진단, [키워드] agammaglobulinemia age-matched control analyzed Anti-spike anti-Spike IgG antibody production Antibody Response Atypical B-cell B-cells binding domain BNT162b2 BNT162b2 vaccine Cohort common Common variable immune deficiencies COVID-19 CVID detectable generate Germinal center healthy heterogeneous IgA IgG immune response immune responses immunization induced infected patient infected patients infected with SARS-CoV-2 Infection memory Memory cells naïve occurred of BNT162b2 one patient Patient patients Primary antibody deficiencies raising RBD Reactions Receptor-binding-domain Reinfection response Result SARS-CoV-2 SARS-COV-2 infection second dose Seven Specific specificity Spike protein spike-specific IgG subsequent supplementary material T-cell T-cell Response T-cells undetectable vaccination Vaccine vaccine dose variable while X-linked X-linked agammaglobulinemia XLA [DOI] 10.1007/s10875-021-01133-0 PMC 바로가기 [Article Type] Original Article